Penicillin-binding protein 2B
Details
- Name
- Penicillin-binding protein 2B
- Synonyms
- pbp2b
- Gene Name
- penA
- Organism
- Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
- Amino acid sequence
>lcl|BSEQ0006970|Penicillin-binding protein 2B MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSAR GEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYY LADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEIYLFSQ LNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE KAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIE EGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSG IKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVFQGSAP INSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRS TFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGV RVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTT GRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNG VGPSIARDIINLYQKYHPMN
- Number of residues
- 680
- Molecular Weight
- 73872.305
- Theoretical pI
- 4.85
- GO Classification
- Functionspenicillin bindingProcessescell wall organization / peptidoglycan biosynthetic process / regulation of cell shape / response to antibioticComponentsintegral component of membrane / plasma membrane
- General Function
- Not Available
- Specific Function
- Penicillin binding
- Pfam Domain Function
- Transmembrane Regions
- 9-29
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017168|Penicillin-binding protein 2B (penA) ATGAGACTGATTTGTATGAGAAAATTTAACAGCCATTCGATTCCGATTCGGCTTAATTTA TTGTTTTCAATCGTCATTTTACTCTTTATGACCATTATTGGTCGTTTGTTGTATATGCAG GTTTTGAACAAGGATTTTTACGAAAAAAAGCTAGCCTCAGCTAGTCAGACCAAGATTACA AGCAGTTCAGCCCGTGGGGAAATTTATGATGCTAGTGGAAAACCTTTGGTAGAAAATACG TTAAAGCAGGTTGTTTCCTTTACGCGTAGCAATAAAATGACGGCTACAGACTTAAAAGAA ACAGCTAAAAAGTTACTGACTTATGTGAGCATCAGTTCTCCAAATTTGACAGAACGCCAG CTGGCGGATTACTATTTGGCTGATCCTGAAATCTATAAAAAAATAGTGGAAGCTCTCCCA AGCGAGAAACGCTTGGATTCAGATGGCAATCGTCTATCCGAATCAGAACTGTATAACAAT GCGGTCGATAGTGTACAAACGAGTCAACTAAACTATACAGAGGATGAAAAGAAAGAAATC TATCTTTTTAGTCAGTTAAATGCTGTTGGAAACTTTGCGACAGGAACCATTGCTACAGAT CCTCTAAATGATTCTCAGGTGGCTGTTATTGCCTCTATTTCAAAGGAGATGCCTGGCATT AGTATTTCTACTTCTTGGGATAGAAAGGTTTTGGAAACTTCCCTTTCTTCTATAGTTGGG AGTGTATCCAGTGAAAAAGCTGGTCTCCCAGCGGAAGAAGCAGAAGCCTATCTTAAAAAA GGCTATTCTCTAAATGACCGTGTAGGAACCTCCTATTTGGAAAAGCAATATGAAGAGACC TTACAAGGAAAACGCTCGGTAAAAGAAATCCATCTGGATAAATATGGCAATATGGAAAGC GTGGATACAATTGAGGAAGGTAGTAAGGGAAACAATATCAAACTGACCATTGATTTGGCT TTCCAAGATAGCGTGGATGCTTTACTGAAAAGTTATTTCAATTCTGAGCTAGAAAATGGT GGAGCCAAGTATTCTGAAGGTGTCTATGCAGTCGCCCTTAACCCAAAAACAGGTGCGGTT TTGTCTATGTCAGGGATTAAACATGACTTGAAAACGGGAGAGTTGACGCCTGATTCCTTG GGAACGGTAACCAATGTCTTTGTTCCAGGTTCGGTTGTCAAGGCGGCGACCATCAGCTCA GGTTGGGAAAATGGAGTCTTGTCAGGAAACCAGACCTTGACAGACCAGTCCATTGTCTTC CAAGGTTCAGCTCCCATCAATTCTTGGTATACTCAGGCTTACGGTTCATTCCCTATCACA GCGGTCCAAGCTCTGGAGTATTCATCAAATACCTATATGGTCCAAACAGCCTTAGGTCTT ATGGGGCAAACCTATCAACCCAATATGTTTGTCGGCACCAGCAATCTAGAGTCTGCTATG GAGAAACTGCGTTCAACCTTTGGCGAATATGGCTTGGGTACTGCGACAGGAATTGACCTA CCAGATGAATCTACTGGATTTGTTCCCAAAGAGTATAGCTTTGCTAATTACATTACTAAT GCCTTTGGGCAGTTTGATAACTATACGCCGATGCAGTTGGCTCAGTATGTAGCAACTATT GCAAATAATGGTGTTCGTGTGGCTCCTCGTATTGTTGAAGGCATTTATGGTAATAATGAT AAGGGAGGACTGGGTGACTTGATTCAGCAACTGCAACCGACAGAGATGAATAAGGTCAAT ATATCCGACTCCGATATGAGCATCTTGCACCAAGGTTTTTATCAGGTTGCCCATGGTACT AGTGGATTGACAACTGGACGTGCCTTTTCAAATGGTGCCTTGGTATCCATTAGCGGAAAA ACAGGTACAGCCGAAAGCTATGTGGCAGATGGTCAGCAAGCAACCAATACCAATGCGGTG GCCTATGCCCCATCTGATAATCCCCAAATCGCTGTCGCAGTGGTCTTTCCTCATAATACC AATCTAACAAATGGTGTAGGACCTTCCATTGCGCGTGACATTATCAATCTGTATCAAAAA TACCATCCAATGAATTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A3M6 UniProtKB Entry Name PBP2_STRR6 GenBank Protein ID 984233 GenBank Gene ID X16022 - General References
- Dowson CG, Hutchison A, Spratt BG: Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6. Nucleic Acids Res. 1989 Sep 25;17(18):7518. [Article]
- Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI: Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17. [Article]
- Dowson CG, Hutchison A, Spratt BG: Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae. Mol Microbiol. 1989 Jan;3(1):95-102. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01066 Cefditoren approved, investigational yes inhibitor Details DB01212 Ceftriaxone approved yes inhibitor Details DB01140 Cefadroxil approved, vet_approved, withdrawn yes inhibitor Details DB00493 Cefotaxime approved yes inhibitor Details DB00319 Piperacillin approved yes inhibitor Details DB00607 Nafcillin approved, investigational yes inhibitor Details DB00415 Ampicillin approved, vet_approved yes inhibitor Details DB00485 Dicloxacillin approved, investigational, vet_approved yes inhibitor Details DB01163 Amdinocillin investigational, withdrawn yes inhibitor Details DB01603 Meticillin approved, investigational yes inhibitor Details DB00456 Cefalotin approved, investigational, vet_approved yes inhibitor Details DB00713 Oxacillin approved, investigational yes inhibitor Details DB01331 Cefoxitin approved yes inhibitor Details DB00567 Cephalexin approved, investigational, vet_approved yes inhibitor Details DB03313 Cephalosporin C experimental yes inhibitor Details DB08795 Azidocillin experimental yes inhibitor Details DB00739 Hetacillin approved, vet_approved, withdrawn yes inhibitor Details DB14733 Ceftobiprole medocaril approved, experimental, investigational yes inhibitor Details DB04918 Ceftobiprole approved, investigational yes inhibitor Details