Genome of the bacterium Streptococcus pneumoniae strain R6.
Article Details
- CitationCopy to clipboard
Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI
Genome of the bacterium Streptococcus pneumoniae strain R6.
J Bacteriol. 2001 Oct;183(19):5709-17.
- PubMed ID
- 11544234 [ View in PubMed]
- Abstract
Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because the R6 strain is avirulent and, more importantly, because it is readily transformed with DNA from homologous species and many heterologous species, it is the principal platform for investigation of the biology of this important pathogen. It is also used as a primary vehicle for genomics-based development of antibiotics for gram-positive bacteria. In our analysis of the genome, we identified a large number of new uncharacterized genes predicted to encode proteins that either reside on the surface of the cell or are secreted. Among those proteins there may be new targets for vaccine and antibiotic development.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Penicillin-binding protein 2X P59676 Details Chorismate synthase P0A2Y7 Details Peptide deformylase Q8DP79 Details Holo-[acyl-carrier-protein] synthase P0A2W7 Details Penicillin-binding protein 2B P0A3M6 Details UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Details Penicillin-binding protein 1A Q8DR59 Details Penicillin-binding protein 1b Q7CRA4 Details Penicillin-binding protein 2a Q8DNB6 Details