Alpha1-adrenoceptor subtypes and lower urinary tract symptoms.
Article Details
- CitationCopy to clipboard
Schwinn DA, Roehrborn CG
Alpha1-adrenoceptor subtypes and lower urinary tract symptoms.
Int J Urol. 2008 Mar;15(3):193-9. doi: 10.1111/j.1442-2042.2007.01956.x.
- PubMed ID
- 18304211 [ View in PubMed]
- Abstract
Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in aging men leading to lower urinary tract symptoms (LUTS). alpha(1)-Adrenoceptors (alpha(1)ARs) antagonists (blockers) have become a mainstay of LUTS treatment because they relax prostate smooth muscle and decrease urethral resistance, as well as relieving bladder LUTS symptoms. A review of key recent clinical trials suggests new insights into the role of specific alpha(1)AR subtypes in the treatment of LUTS.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Doxazosin Alpha-1A adrenergic receptor Protein Humans YesAntagonistDetails Doxazosin Alpha-1B adrenergic receptor Protein Humans UnknownNot Available Details Doxazosin Alpha-1D adrenergic receptor Protein Humans YesAntagonistDetails