Alpha-1B adrenergic receptor
Details
- Name
- Alpha-1B adrenergic receptor
- Synonyms
- Alpha-1B adrenoceptor
- Alpha-1B adrenoreceptor
- Gene Name
- ADRA1B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010399|Alpha-1B adrenergic receptor MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
- Number of residues
- 520
- Molecular Weight
- 56835.375
- Theoretical pI
- 9.79
- GO Classification
- Functionsalpha1-adrenergic receptor activity / protein heterodimerization activityProcessesadenylate cyclase-activating adrenergic receptor signaling pathway / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / adult heart development / behavioral response to cocaine / blood vessel remodeling / cell growth / cell proliferation / cell-cell signaling / G-protein coupled receptor signaling pathway / glucose homeostasis / intracellular signal transduction / locomotory behavior / multicellular organismal development / negative regulation of glycogen catabolic process / norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure / organ growth / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / positive regulation of glycogen catabolic process / positive regulation of heart rate by epinephrine-norepinephrine / positive regulation of MAPK cascade / positive regulation of smooth muscle contraction / positive regulation of the force of heart contraction by epinephrine-norepinephrine / positive regulation of vasoconstriction / regulation of cardiac muscle contraction / response to amphetamine / response to morphine / vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure / visual learningComponentscytosol / integral component of plasma membrane / nuclear membrane / nucleus / plasma membrane
- General Function
- Protein heterodimerization activity
- Specific Function
- This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 46-70 84-105 116-141 162-184 202-224 296-319 327-351
- Cellular Location
- Nucleus membrane
- Gene sequence
>lcl|BSEQ0010400|Alpha-1B adrenergic receptor (ADRA1B) ATGAATCCCGACCTGGACACCGGCCACAACACATCAGCACCTGCCCACTGGGGAGAGTTG AAAAATGCCAACTTCACTGGCCCCAACCAGACCTCGAGCAACTCCACACTGCCCCAGCTG GACATCACCAGGGCCATCTCTGTGGGCCTGGTGCTGGGCGCCTTCATCCTCTTTGCCATC GTGGGCAACATCCTAGTCATCTTGTCTGTGGCCTGCAACCGGCACCTGCGGACGCCCACC AACTACTTCATTGTCAACCTGGCCATGGCCGACCTGCTGTTGAGCTTCACCGTCCTGCCC TTCTCAGCGGCCCTAGAGGTGCTCGGCTACTGGGTGCTGGGGCGGATCTTCTGTGACATC TGGGCAGCCGTGGATGTCCTGTGCTGCACAGCGTCCATTCTGAGCCTGTGCGCCATCTCC ATCGATCGCTACATCGGGGTGCGCTACTCTCTGCAGTATCCCACGCTGGTCACCCGGAGG AAGGCCATCTTGGCGCTGCTCAGTGTCTGGGTCTTGTCCACCGTCATCTCCATCGGGCCT CTCCTTGGGTGGAAGGAGCCGGCACCCAACGATGACAAGGAGTGCGGGGTCACCGAAGAA CCCTTCTATGCCCTCTTCTCCTCTCTGGGCTCCTTCTACATCCCTCTGGCGGTCATTCTA GTCATGTACTGCCGTGTCTATATAGTGGCCAAGAGAACCACCAAGAACCTAGAGGCAGGA GTCATGAAGGAGATGTCCAACTCCAAGGAGCTGACCCTGAGGATCCATTCCAAGAACTTT CACGAGGACACCCTTAGCAGTACCAAGGCCAAGGGCCACAACCCCAGGAGTTCCATAGCT GTCAAACTTTTTAAGTTCTCCAGGGAAAAGAAAGCAGCTAAGACGTTGGGCATTGTGGTC GGTATGTTCATCTTGTGCTGGCTACCCTTCTTCATCGCTCTACCGCTTGGCTCCTTGTTC TCCACCCTGAAGCCCCCCGACGCCGTGTTCAAGGTGGTGTTCTGGCTGGGCTACTTCAAC AGCTGCCTCAACCCCATCATCTACCCATGCTCCAGCAAGGAGTTCAAGCGCGCTTTCGTG CGCATCCTCGGGTGCCAGTGCCGCGGCCGCGGCCGCCGCCGACGCCGCCGCCGCCGTCGC CTGGGCGGCTGCGCCTACACCTACCGGCCGTGGACGCGCGGCGGCTCGCTGGAGCGCTCG CAGTCGCGCAAGGACTCGCTGGACGACAGCGGCAGCTGCCTGAGCGGCAGCCAGCGGACC CTGCCCTCGGCCTCGCCGAGCCCGGGCTACCTGGGCCGCGGCGCGCCACCGCCAGTCGAG CTGTGCGCCTTCCCCGAGTGGAAGGCGCCCGGCGCCCTCCTGAGCCTGCCCGCGCCTGAG CCCCCCGGCCGCCGCGGCCGCCACGACTCGGGCCCGCTCTTCACCTTCAAGCTCCTGACC GAGCCCGAGAGCCCCGGGACCGACGGCGGCGCCAGCAACGGAGGCTGCGAGGCCGCGGCC GACGTGGCCAACGGGCAGCCGGGCTTCAAAAGCAACATGCCCCTGGCGCCCGGGCAGTTT TAG
- Chromosome Location
- 5
- Locus
- 5q23-q32
- External Identifiers
Resource Link UniProtKB ID P35368 UniProtKB Entry Name ADA1B_HUMAN GenBank Gene ID M99589 GenAtlas ID ADRA1B HGNC ID HGNC:278 - General References
- Ramarao CS, Denker JM, Perez DM, Gaivin RJ, Riek RP, Graham RM: Genomic organization and expression of the human alpha 1B-adrenergic receptor. J Biol Chem. 1992 Oct 25;267(30):21936-45. [Article]
- Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA, et al.: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol Pharmacol. 1994 Apr;45(4):703-8. [Article]
- Schwinn DA, Johnston GI, Page SO, Mosley MJ, Wilson KH, Worman NP, Campbell S, Fidock MD, Furness LM, Parry-Smith DJ, et al.: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther. 1995 Jan;272(1):134-42. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Wright CD, Chen Q, Baye NL, Huang Y, Healy CL, Kasinathan S, O'Connell TD: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ Res. 2008 Oct 24;103(9):992-1000. doi: 10.1161/CIRCRESAHA.108.176024. Epub 2008 Sep 18. [Article]
- Wright CD, Wu SC, Dahl EF, Sazama AJ, O'Connell TD: Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes. Cell Signal. 2012 Mar;24(3):794-802. doi: 10.1016/j.cellsig.2011.11.014. Epub 2011 Nov 18. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00298 Dapiprazole approved yes antagonist Details DB00706 Tamsulosin approved, investigational unknown antagonist Details DB00745 Modafinil approved, investigational unknown partial agonist Details DB01162 Terazosin approved yes antagonist Details DB01403 Methotrimeprazine approved, investigational unknown antagonist Details DB00457 Prazosin approved yes antagonist Details DB00723 Methoxamine approved, investigational unknown agonist Details DB01608 Periciazine approved, investigational unknown antagonist Details DB01576 Dextroamphetamine approved, illicit unknown antagonist Details DB01579 Phendimetrazine approved, illicit unknown agonist Details DB00368 Norepinephrine approved yes agonist Details DB00211 Midodrine approved yes agonist Details DB01149 Nefazodone approved, withdrawn unknown other/unknown Details DB00334 Olanzapine approved, investigational unknown antagonist Details DB00388 Phenylephrine approved yes agonist Details DB00346 Alfuzosin approved, investigational yes antagonist Details DB04855 Dronedarone approved yes antagonist Details DB06144 Sertindole approved, investigational, withdrawn unknown Details DB05469 R450 investigational unknown Details DB05492 Epicept NP-1 investigational unknown Details DB06262 Droxidopa approved, investigational yes agonist Details DB06229 Ocaperidone investigational unknown Details DB01186 Pergolide approved, investigational, vet_approved, withdrawn unknown agonist Details DB01200 Bromocriptine approved, investigational, withdrawn unknown antagonistagonist Details DB00622 Nicardipine approved, investigational unknown antagonist Details DB01267 Paliperidone approved unknown antagonist Details DB00246 Ziprasidone approved unknown antagonist Details DB00363 Clozapine approved no antagonist Details DB01238 Aripiprazole approved, investigational no antagonist Details DB00726 Trimipramine approved unknown antagonist Details DB00696 Ergotamine approved yes partial agonist Details DB01142 Doxepin approved, investigational unknown antagonist Details DB00477 Chlorpromazine approved, investigational, vet_approved yes antagonist Details DB00679 Thioridazine approved, withdrawn yes antagonist Details DB01614 Acepromazine experimental, vet_approved unknown antagonist Details DB01622 Thioproperazine experimental yes antagonist Details DB06694 Xylometazoline approved, investigational unknown agonist Details DB00668 Epinephrine approved, vet_approved yes agonist Details DB06207 Silodosin approved yes antagonist Details DB00408 Loxapine approved unknown binder Details DB00458 Imipramine approved unknown antagonist Details DB01136 Carvedilol approved, investigational unknown antagonist Details DB00575 Clonidine approved unknown agonist Details DB00540 Nortriptyline approved unknown antagonist Details DB00800 Fenoldopam approved unknown inhibitor Details DB00248 Cabergoline approved unknown binder Details DB00321 Amitriptyline approved unknown antagonist Details DB00925 Phenoxybenzamine approved unknown antagonist Details DB00935 Oxymetazoline approved, investigational unknown agonist Details DB09202 Cirazoline experimental yes partial agonist Details DB09128 Brexpiprazole approved, investigational unknown antagonist Details DB00908 Quinidine approved, investigational unknown antagonist Details DB00661 Verapamil approved unknown antagonist Details DB11124 Racepinephrine approved yes agonist Details DB06153 Pizotifen approved unknown antagonist Details DB14185 Aripiprazole lauroxil approved, investigational no antagonist Details DB00590 Doxazosin approved unknown Details DB00734 Risperidone approved, investigational unknown antagonist Details DB09185 Viloxazine approved, investigational, withdrawn unknown antagonist Details DB00598 Labetalol approved yes antagonist Details DB00934 Maprotiline approved, investigational no antagonist Details DB01224 Quetiapine approved unknown antagonist Details DB01151 Desipramine approved, investigational no antagonist Details DB00477 Chlorpromazine approved, investigational, vet_approved unknown inhibitor Details DB00370 Mirtazapine approved unknown antagonist Details DB00543 Amoxapine approved unknown antagonist Details DB06148 Mianserin approved, investigational unknown antagonist Details DB06764 Tetryzoline approved yes agonist Details DB13025 Tiapride investigational yes antagonist Details DB08922 Perospirone experimental unknown antagonist Details DB09167 Dosulepin approved yes antagonist Details DB00841 Dobutamine approved yes agonist Details DB09203 Synephrine experimental unknown Details DB09194 Etoperidone withdrawn unknown antagonist Details DB09195 Lorpiprazole approved yes antagonist Details DB09204 Arotinolol investigational yes antagonist Details DB09286 Pipamperone investigational unknown antagonist Details DB00243 Ranolazine approved, investigational no antagonist Details DB00457 Prazosin approved unknown Details DB00697 Tizanidine approved, investigational unknown agonist Details DB00433 Prochlorperazine approved, vet_approved unknown antagonist Details DB00490 Buspirone approved, investigational unknown partial agonist Details DB00715 Paroxetine approved, investigational unknown binder Details DB01175 Escitalopram approved unknown inhibitor Details DB01136 Carvedilol approved, investigational yes inhibitor Details DB00346 Alfuzosin approved, investigational yes antagonist Details DB00320 Dihydroergotamine approved, investigational unknown agonist Details DB00692 Phentolamine approved yes antagonist Details DB01365 Mephentermine approved yes agonist Details DB00182 Amphetamine approved, illicit, investigational unknown agonist Details DB09205 Moxisylyte approved, investigational yes antagonist Details DB09229 Aranidipine experimental unknown agonist Details DB11577 Indigotindisulfonic acid approved, investigational no agonist Details DB13345 Dihydroergocristine approved, experimental yes antagonistagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB11278 DL-Methylephedrine approved yes agonist Details DB00268 Ropinirole approved, investigational unknown antagonist Details DB01069 Promethazine approved, investigational unknown antagonist Details DB01576 Dextroamphetamine approved, illicit unknown inhibitorinducer Details