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Displaying drugs 76 - 100 of 13272 in total
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the...
Approved
Matched Synonyms: … Neovitamin A acid ... 13-cis-Vitamin A acid …
Matched Description: … Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne. ... the iPLEDGE program in the United States. ... [L6574] Isotretinoin is associated with major risks in pregnancy and is therefore only available under …
Matched Categories: … Retinoids for Topical Use in Acne …
Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. Since glatiramer acetate is a heterogeneous drug, there is limited information about its physicochemical properties. Originally, glatiramer acetate was designed as a...
Approved
Investigational
Matched Synonyms: … (T,G)-A-L …
Matched Description: … [A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. ... [A248870] Originally, glatiramer acetate was designed as a stimulant of myelin basic protein (MBP), a ... myelin antigen involved in the development of multiple sclerosis (MS), to induce experimental autoimmune …
Matched Products: … Copaxone 20 mg/ml Injektionslösung in einer Fertigspritze ... Copaxone 40 mg/ml Injektionslösung in einer Fertigspritze ... Copaxobene 20 mg/ml Injektionslösung in einer Fertigspritze …
Atidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A (ARSA) gene. Libmeldy was granted orphan designation by the EMA in April 2007, and was...
Approved
Matched Synonyms: … lentiviral vector encoding the human arylsulfatase A (ARSA) gene ... enriched population that contains haematopoietic stem and progenitor cells (HSPC) transduced ex vivo using a ... Autologous CD34+ cells transduced with lentiviral vector which encodes for the aryl Sulfatase A complimentary …
Matched Description: … [L45191] Libmeldy was granted orphan designation by the EMA in April 2007, and was issued a marketing ... authorization in the EU in December 2020 for the treatment of certain manifestations of metachromatic ... lentiviral vector encoding the human arylsulfatase A (ARSA) gene. …
Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino...
Approved
Matched Synonyms: … Gramicidin A
Matched Description: … topical antibiotic and is also found in Polysporin ophthalmic solution. ... Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making ... amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Synonyms: … 6-O-methylerythromycin A
Matched Description: … Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein …
Matched Products: … MACROMYCIN GRÁNULOS PARA RECONSTITUIR A SUSPENSIÓN ORAL ... ROLICYTIN® 250 MG/5 ML POLVO PARA RECONSTITUIR A SUSPENSION ORAL ... CLARITROMICINA 250MG/5ML GRANULOS PARA RECONSTITUIR A SUSPENSION ORAL. …
Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. It is prepared from heating fresh liquid resin to vaporize the volatile liquid terpene components. Rosin is used in various commercial and industrial applications, including printing, lead-tin industry, and food production. In the pharmaceuticals, rosin...
Approved
Matched Synonyms: … Wood rosin …
Matched Description: … Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. ... In the pharmaceuticals, rosin is used in film forming and coating tablets and enterically administered ... Rosin is used in various commercial and industrial applications, including printing, lead-tin industry …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.
Approved
Matched Synonyms: … 5,6,7,8-Tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)ethyl)-s-triazolo(4,3-a)pyridine …
Matched Iupac: … 1-(2-methylphenyl)-4-(2-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)piperazine …
Matched Description: … It is found in ophthalmic solutions used to reverse mydriasis after an eye examination. …
Meningococcal group W-135 polysaccharide is group-specific polysaccharide antigens extracted and purified from Neisseria meningitidis serogroup W-135. N. meningitidis is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia. It is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup W-135.
Approved
Experimental
Investigational
Matched Synonyms: … Neisseria meningitidis group W-135 polysaccharide antigen, A
Matched Description: … *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia …
Matched Mixtures name: … Menomune-A/c/y/w-135 ... Menomune-A/c/y/w-135 ... Menomune-A/c/y/w-135 …
Tofersen is under an intrathecally administered antisense oligonucleotide targeting the mutated SOD1 gene that causes amyotrophic lateral sclerosis (ALS). Although there were various causes of ALS, 2% of ALS cases are due to SOD1 mutations, with more than 200 SOD1 mutations documented.[A259028,A259033] Tofersen was granted accelerated approval from the FDA...
Approved
Investigational
Matched Synonyms: … METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-T-SP-M5C-SP-T-SP-A-SP …
Matched Description: … [L46133] Tofersen demonstrated efficacy in reducing the concentration of SOD1 in CSF and of neurofilament ... light chains in plasma over 28 weeks, although the ALS Functional Rating Scale–Revised did not improve ... approval is contingent on clinical benefits from ongoing trials, particularly the Phase 3 ATLAST study in
Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78...
Approved
Matched Synonyms: … FSH-a
Matched Description: … However, a more recent study showed there is may be a slight clinical difference, with the alpha form ... tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but ... assist in ovulation and fertility. …
Matched Products: … REKOVELLE SOLUTION FOR INJECTION IN A PRE-FILLED PEN 12MCG/0.36ML ... REKOVELLE SOLUTION FOR INJECTION IN A PRE-FILLED PEN 72MCG/2.16ML ... REKOVELLE SOLUTION FOR INJECTION IN A PRE-FILLED PEN 36MCG/1.08ML …
Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival. On April 23 2021, the Food and Drug Administration granted accelerated...
Approved
Investigational
Matched Synonyms: … Humanized monoclonal immunoglobulin G1 antibody directed against human CD19 conjugated to SG3199 through A
Matched Description: … Zylonta also received approval in the EU on December 22, 2022. ... Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients …
Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity and mild aromatase inhibitor activity....
Approved
Investigational
Withdrawn
Matched Synonyms: … 4-OH-A
Matched Iupac: … 9bS,11aS)-6-hydroxy-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. ... Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity ... Currently, formestane (categorized as an anti-estrogenic agent) is prohibited from use in sports in accordance …
Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The amylases are enzymes that help in the chemical process of digestion by hydrolizing starch into more available saccharide forms. The pancrelipase amylase is a...
Approved
Matched Synonyms: … Amylase A
Matched Description: … Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases ... [L2509] The amylases are enzymes that help in the chemical process of digestion by hydrolizing starch ... [T177] The pancrelipase amylase is a single polypeptide chain containing two SH groups and four disulfide …
Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through...
Approved
Investigational
Vet approved
Matched Synonyms: … D-Glucose in linear form …
Matched Description: … a basic health system. ... L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. ... Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and …
Matched Mixtures name: … Acd-A ... Anticoagulant Citrate Dextrose A ACD-A ... Acd A
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … DEXTROSE 5% IN DIS.WATER INJ 500ML ... DEXTROSE 5% IN DIS.WATER INJ 1000ML ... DEXTROSE 10% IN DIS.WATER INJ 500ML …
An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Approved
Investigational
Nutraceutical
Matched Synonyms: … a-Ketopropionic acid …
Matched Description: … In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous ... An intermediate compound in the metabolism of carbohydrates, proteins, and fats. …
Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers. Although multikinase inhibitors, including cabozantinib, ponatinib, sorafenib, sunitinib, and vandetanib, have shown efficacy in RET-driven cancers, their...
Approved
Investigational
Matched Synonyms: … -(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a] …
Matched Iupac: … -(6-{6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl}pyridin-3-yl)pyrazolo[1,5-a] …
Matched Description: … Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs ... [A202055, A202052, L13604] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark ... including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and [vandetanib], have shown efficacy in
An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
Approved
Nutraceutical
Matched Synonyms: … Thr
Matched Description: … It is found in eggs, milk, gelatin, and other proteins. ... An essential amino acid occurring naturally in the L-form, which is the active form. …
Matched Mixtures name: … Aminosyn II in Dextrose ... Aminosyn II in Dextrose ... Aminosyn II in Dextrose …
Mupirocin, formerly termed pseudomonic acid A, is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism Pseudomonas fluorescens, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain gram-negative...
Approved
Investigational
Vet approved
Matched Synonyms: … Pseudomonic acid A
Matched Description: … Mupirocin, formerly termed pseudomonic acid A,[A178531] is a novel antibacterial agent with a unique ... is used in the treatment of impetigo caused by _Staphylococcus aureus_ and _Streptococcus pyogenes_ ... [L10580] It is available in topical formulations only due to extensive systemic metabolism[A178531] and …
Dihydrostreptomycin is an aminoglycoside antibiotic. In humans, the use of dihydrostreptomycin has been associated with ototoxicity. The FDA withdrew its approval for the use of all drug products containing dihydrostreptomycin sulfate.
Approved
Investigational
Vet approved
Withdrawn
Matched Synonyms: … )-a-L-lyxofuranosyl}oxy)-2,5,6-trihydroxycyclohexane-1,3-diyl]diguanidine ... N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-a-L-glucopyranosyl]-3-C-(hydroxymethyl …
Matched Description: … In humans, the use of dihydrostreptomycin has been associated with ototoxicity. …
Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of...
Approved
Investigational
Matched Synonyms: … Coagulation factor IX, II, VII and X in combination …
Matched Description: … Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting ... factors found in functioning human plasma. ... acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in
Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured by the company, Ipsen...
Approved
Matched Description: … Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess ... This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. ... Lanreotide was first approved for use in the United States by the FDA on August 30, 2007. …
Matched Products: … Somatuline Autogel 120mg, prolonged-release solution for injection in a pre-filled syringe ... Somatuline Autogel 60mg, prolonged-release solution for injection in a pre-filled syringe ... Somatuline Autogel 90mg, prolonged-release solution for injection in a pre-filled syringe …
Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening ... as Abasaglar in the EU. ... is a slowly progressing metabolic disorder caused by a combination of genetic and lifestyle factors …
Matched Mixtures name: … Soliqua SoloStar 100units/mL+33mcg/mL solution for injection in a pre-filled pen ... SOLIQUA SOLUTION FOR INJECTION IN A PRE-FILLED PEN 100UNITS/ML + 50MCG/ML ... SOLIQUA SOLUTION FOR INJECTION IN A PRE-FILLED PEN 100UNITS/ML + 33MCG/ML …
Matched Categories: … Drugs Used in Diabetes …
Matched Products: … BASALOG 100 IU/mL, SOLUTION FOR INJECTION IN A VIAL ... LANTUS 100 Units/ml Solution for injection in a vial ... LANTUS SOLOSTAR 100IU/ML SOLUTION FOR INJECTION IN A PRE-FILLED PEN …
Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, filgrastim. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti-cancer treatment. Although the risk of developing febrile neutropenia...
Approved
Matched Description: … It is typically administered via a subcutaneous injection. ... drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in ... [L9779,L9785,L43050] These biosimilars are highly similar to the reference product, Neulasta, in terms …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Pelgraz 6 mg solution for injection in a pre-filled syringe ... NUFILONG SOLUTION FOR INJECTION IN A PRE-FILLED SYRINGE 6MG/0.6ML ... Pelgraz Solution for Injection in pre-filled syringe 6mg/0.6mL …
Inula helenium root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Synonyms: … Wood Fragrance (Inula Helenium) …
Matched Description: … Inula helenium root is a plant/plant extract used in some OTC (over-the-counter) products. …
Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate...
Approved
Investigational
Matched Synonyms: … 1-[(1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[a][1,3]dioxolo[4,5-H]pyrrolo[2,1-b][ …
Matched Description: … protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies ... Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and ... Then in March 2006, it received Orphan Drug status from the FDA for the treatment of CML. …
Displaying drugs 76 - 100 of 13272 in total