Histone deacetylase 11
Details
- Name
- Histone deacetylase 11
- Synonyms
- 3.5.1.98
- HD11
- Gene Name
- HDAC11
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049421|Histone deacetylase 11 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
- Number of residues
- 347
- Molecular Weight
- 39182.76
- Theoretical pI
- Not Available
- GO Classification
- Functionshistone deacetylase activity / NAD-dependent histone deacetylase activity (H3-K14 specific) / transcription factor bindingProcesseschromatin organization / histone deacetylation / oligodendrocyte development / regulation of transcription, DNA-templated / transcription, DNA-templatedComponentsextracellular exosome / histone deacetylase complex / nucleus / plasma membrane
- General Function
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
- Specific Function
- Histone deacetylase activity
- Pfam Domain Function
- Hist_deacetyl (PF00850)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0049422|Histone deacetylase 11 (HDAC11) ATGCTACACACAACCCAGCTGTACCAGCATGTGCCAGAGACACGCTGGCCAATCGTGTAC TCGCCGCGCTACAACATCACCTTCATGGGCCTGGAGAAGCTGCATCCCTTTGATGCCGGA AAATGGGGCAAAGTGATCAATTTCCTAAAAGAAGAGAAGCTTCTGTCTGACAGCATGCTG GTGGAGGCGCGGGAGGCCTCGGAGGAGGACCTGCTGGTGGTGCACACGAGGCGCTATCTT AATGAGCTCAAGTGGTCCTTTGCTGTTGCTACCATCACAGAAATCCCCCCCGTTATCTTC CTCCCCAACTTCCTTGTGCAGAGGAAGGTGCTGAGGCCCCTTCGGACCCAGACAGGAGGA ACCATAATGGCGGGGAAGCTGGCTGTGGAGCGAGGCTGGGCCATCAACGTGGGGGGTGGC TTCCACCACTGCTCCAGCGACCGTGGCGGGGGCTTCTGTGCCTATGCGGACATCACGCTC GCCATCAAGTTTCTGTTTGAGCGTGTGGAGGGCATCTCCAGGGCTACCATCATTGATCTT GATGCCCATCAGGGCAATGGGCATGAGCGAGACTTCATGGACGACAAGCGTGTGTACATC ATGGATGTCTACAACCGCCACATCTACCCAGGGGACCGCTTTGCCAAGCAGGCCATCAGG CGGAAGGTGGAGCTGGAGTGGGGCACAGAGGATGATGAGTACCTGGATAAGGTGGAGAGG AACATCAAGAAATCCCTCCAGGAGCACCTGCCCGACGTGGTGGTATACAATGCAGGCACC GACATCCTCGAGGGGGACCGCCTTGGGGGGCTGTCCATCAGCCCAGCGGGCATCGTGAAG CGGGATGAGCTGGTGTTCCGGATGGTCCGTGGCCGCCGGGTGCCCATCCTTATGGTGACC TCAGGCGGGTACCAGAAGCGCACAGCCCGCATCATTGCTGACTCCATACTTAATCTGTTT GGCCTGGGGCTCATTGGGCCTGAGTCACCCAGCGTCTCCGCACAGAACTCAGACACACCG CTGCTTCCCCCTGCAGTGCCCTGA
- Chromosome Location
- 3
- Locus
- 3p25.1
- External Identifiers
Resource Link UniProtKB ID Q96DB2 UniProtKB Entry Name HDA11_HUMAN HGNC ID HGNC:19086 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB05015 Belinostat approved, investigational yes inhibitor Details DB06603 Panobinostat approved, investigational yes inhibitor Details DB02546 Vorinostat approved, investigational unknown inhibitor Details DB12847 Pyroxamide investigational unknown inhibitor Details DB00313 Valproic acid approved, investigational unknown inhibitor Details DB11841 Entinostat investigational yes inhibitor Details DB06819 Phenylbutyric acid approved, investigational unknown inhibitor Details DB12645 Givinostat approved, investigational yes inhibitor Details DB06176 Romidepsin approved, investigational unknown inhibitor Details DB01262 Decitabine approved, investigational unknown inhibitor Details DB12565 Abexinostat investigational unknown inhibitor Details DB03766 Propanoic acid approved, vet_approved unknown inhibitor Details