The DNA sequence, annotation and analysis of human chromosome 3.
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Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
The DNA sequence, annotation and analysis of human chromosome 3.
Nature. 2006 Apr 27;440(7088):1194-8.
- PubMed ID
- 16641997 [ View in PubMed]
- Abstract
After the completion of a draft human genome sequence, the International Human Genome Sequencing Consortium has proceeded to finish and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes. Chromosome 3 comprises just four contigs, one of which currently represents the longest unbroken stretch of finished DNA sequence known so far. The chromosome is remarkable in having the lowest rate of segmental duplication in the genome. It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B. Using genomic sequence from chimpanzee and rhesus macaque, we were able to characterize the breakpoints defining a large pericentric inversion that occurred some time after the split of Homininae from Ponginae, and propose an evolutionary history of the inversion.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Aminomethyltransferase, mitochondrial P48728 Details Transketolase P29401 Details Pyruvate dehydrogenase E1 component subunit beta, mitochondrial P11177 Details Sodium channel protein type 10 subunit alpha Q9Y5Y9 Details Sodium channel protein type 11 subunit alpha Q9UI33 Details Sodium channel protein type 5 subunit alpha Q14524 Details Peroxisome proliferator-activated receptor gamma P37231 Details Calcium-transporting ATPase type 2C member 1 P98194 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial O43674 Details Sodium- and chloride-dependent GABA transporter 1 P30531 Details Sodium-coupled neutral amino acid transporter 3 Q99624 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 O95168 Details Retinol-binding protein 1 P09455 Details Thyroid hormone receptor beta P10828 Details GMP synthase [glutamine-hydrolyzing] P49915 Details Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Q96I99 Details 5-hydroxytryptamine receptor 1F P30939 Details Aminoacylase-1 Q03154 Details Serotransferrin P02787 Details Propionyl-CoA carboxylase beta chain, mitochondrial P05166 Details D(3) dopamine receptor P35462 Details Peroxisomal bifunctional enzyme Q08426 Details Choline dehydrogenase, mitochondrial Q8NE62 Details Chloride channel protein 2 P51788 Details Activated CDC42 kinase 1 Q07912 Details Glutathione peroxidase 1 P07203 Details Glutathione peroxidase 3 P22352 Details T-lymphocyte activation antigen CD86 P42081 Details T-lymphocyte activation antigen CD80 P33681 Details C-C chemokine receptor type 5 P51681 Details Cytosolic 10-formyltetrahydrofolate dehydrogenase O75891 Details Catenin beta-1 P35222 Details Lactotransferrin P02788 Details Kininogen-1 P01042 Details Solute carrier family 2, facilitated glucose transporter member 2 P11168 Details Prostatic acid phosphatase P15309 Details Solute carrier family 15 member 2 Q16348 Details Sucrase-isomaltase, intestinal P14410 Details Transforming protein RhoA P61586 Details Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 Q96T66 Details Tetranectin P05452 Details Acidic amino acid decarboxylase GADL1 Q6ZQY3 Details Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 O00469 Details Prolyl 3-hydroxylase 2 Q8IVL5 Details Glutamine--tRNA ligase P47897 Details Succinate receptor 1 Q9BXA5 Details Diacylglycerol kinase gamma P49619 Details Voltage-dependent L-type calcium channel subunit alpha-1D Q01668 Details Voltage-dependent calcium channel subunit alpha-2/delta-2 Q9NY47 Details C-C chemokine receptor type 2 P41597 Details cAMP-dependent protein kinase type II-alpha regulatory subunit P13861 Details Interleukin-5 receptor subunit alpha Q01344 Details Microtubule-associated protein 4 P27816 Details Carboxypeptidase N subunit 2 P22792 Details V-type proton ATPase catalytic subunit A P38606 Details Nischarin Q9Y2I1 Details Gamma-aminobutyric acid receptor subunit rho-3 A8MPY1 Details Multidrug resistance-associated protein 5 O15440 Details Adenylate cyclase type 5 O95622 Details 60S ribosomal protein L15 P61313 Details 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Q16877 Details Guanine nucleotide-binding protein G(t) subunit alpha-1 P11488 Details Poly [ADP-ribose] polymerase 3 Q9Y6F1 Details Arylacetamide deacetylase-like 2 Q6P093 Details Actin-related protein 2/3 complex subunit 4 P59998 Details Poly [ADP-ribose] polymerase 15 Q460N3 Details Calcium-activated potassium channel subunit beta-3 Q9NPA1 Details Uridine 5'-monophosphate synthase P11172 Details 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 P51178 Details Glycogenin-1 P46976 Details 3-ketoacyl-CoA thiolase, peroxisomal P09110 Details Inositol 1,4,5-trisphosphate receptor type 1 Q14643 Details Ras-related protein Rab-5A P20339 Details Sodium bicarbonate cotransporter 3 Q9Y6M7 Details Sodium- and chloride-dependent GABA transporter 3 P48066 Details Protein cereblon Q96SW2 Details Serine/threonine-protein kinase Nek11 Q8NG66 Details 5-hydroxytryptamine receptor 3D Q70Z44 Details 5-hydroxytryptamine receptor 3E A5X5Y0 Details Interphotoreceptor matrix proteoglycan 2 Q9BZV3 Details Sodium/potassium-transporting ATPase subunit beta-3 P54709 Details Histone deacetylase 11 Q96DB2 Details Solute carrier family 41 member 3 Q96GZ6 Details Calcium-dependent secretion activator 1 Q9ULU8 Details Tubulin monoglycylase TTLL3 Q9Y4R7 Details Alpha-2-HS-glycoprotein P02765 Details Inter-alpha-trypsin inhibitor heavy chain H1 P19827 Details Inter-alpha-trypsin inhibitor heavy chain H3 Q06033 Details Inter-alpha-trypsin inhibitor heavy chain H4 Q14624 Details 60S ribosomal protein L14 P50914 Details Sodium- and chloride-dependent taurine transporter P31641 Details Nuclear receptor subfamily 1 group D member 2 Q14995 Details TRAF2 and NCK-interacting protein kinase Q9UKE5 Details Ephrin type-A receptor 6 Q9UF33 Details Ephrin type-B receptor 1 P54762 Details Mitogen-activated protein kinase kinase kinase 13 O43283 Details Macrophage-stimulating protein receptor Q04912 Details Myosin light chain kinase, smooth muscle Q15746 Details Serine/threonine-protein kinase Nek4 P51957 Details P2Y purinoceptor 13 Q9BPV8 Details Potassium voltage-gated channel subfamily H member 8 Q96L42 Details Plasma membrane calcium-transporting ATPase 2 Q01814 Details Beta-galactosidase P16278 Details Hyaluronidase-3 O43820 Details Hyaluronidase-1 Q12794 Details Hyaluronidase-2 Q12891 Details CX3C chemokine receptor 1 P49238 Details Microphthalmia-associated transcription factor O75030 Details Arylacetamide deacetylase P22760 Details