Naphazoline nitrateProduct ingredient for Naphazoline
- Name
- Naphazoline nitrate
- Drug Entry
- Naphazoline
Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles6,7. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations6,7.
Naphazoline was first developed in 1942 as a nasal formulation for congestion4.
- Accession Number
- DBSALT002621
- Structure
- Synonyms
- Not Available
- UNII
- SC99GR1T5S
- CAS Number
- 5144-52-5
- Weight
- Average: 273.292
Monoisotopic: 273.111341355 - Chemical Formula
- C14H15N3O3
- InChI Key
- ZAHXYMFVNNUHCP-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4)
- IUPAC Name
- 2-[(naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole; nitric acid
- SMILES
- O[N+]([O-])=O.C(C1=NCCN1)C1=CC=CC2=C1C=CC=C2
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.0381 mg/mL ALOGPS logP 3.44 ALOGPS logP 2.19 Chemaxon logS -3.7 ALOGPS pKa (Strongest Basic) 10.19 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 24.39 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 65.52 m3·mol-1 Chemaxon Polarizability 23.77 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon