Reaction: Silodosin to 1 product
- Reaction
- Reaction type
- dehydrogenation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- inactive
- References
- Matsubara Y, Kanazawa T, Kojima Y, Abe Y, Kobayashi K, Kanbe H, Harada H, Momose Y, Terakado S, Adachi Y, Midgley I: [Pharmacokinetics and disposition of silodosin (KMD-3213)]. Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45. [Article]
- Vishnuvardhan C, Baikadi S, Borkar RM, Srinivas R, Satheeshkumar N: In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites. J Mass Spectrom. 2016 Oct;51(10):867-882. doi: 10.1002/jms.3795. [Article]
- FDA Approved Drug Products: RAPAFLO (silodosin) Capsule for oral use [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Alcohol dehydrogenase [NADP(+)] Not Available Not Available confirmed Aldehyde dehydrogenase, mitochondrial Not Available Not Available confirmed