Reaction: Codeine to 1 product
- Reaction
- Reaction type
- O-demethylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Caraco Y, Tateishi T, Guengerich FP, Wood AJ: Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos. 1996 Jul;24(7):761-4. [Article]
- Vree TB, Verwey-van Wissen CP: Pharmacokinetics and metabolism of codeine in humans. Biopharm Drug Dispos. 1992 Aug;13(6):445-60. [Article]
- Cregg R, Russo G, Gubbay A, Branford R, Sato H: Pharmacogenetics of analgesic drugs. Br J Pain. 2013 Nov;7(4):189-208. doi: 10.1177/2049463713507439. [Article]
- Codeine FDA label [File]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2D6 Not Available Not Available implied