V-type proton ATPase subunit H
Details
- Name
- V-type proton ATPase subunit H
- Synonyms
- NBP1
- Nef-binding protein 1
- Protein VMA13 homolog
- V-ATPase 50/57 kDa subunits
- V-ATPase subunit H
- Vacuolar proton pump subunit H
- Vacuolar proton pump subunit SFD
- Gene Name
- ATP6V1H
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052463|V-type proton ATPase subunit H MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSPE EKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKN TAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGS GVAVETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQ YQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERE TRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELK SGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRH YPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAA ARS
- Number of residues
- 483
- Molecular Weight
- 55882.71
- Theoretical pI
- Not Available
- GO Classification
- Functionsenzyme regulator activity / proton-transporting ATPase activity, rotational mechanismProcessesendocytosis / insulin receptor signaling pathway / ion transmembrane transport / phagosome acidification / proton transmembrane transport / regulation of defense response to virus by virus / regulation of macroautophagy / transferrin transport / vacuolar acidificationComponentscell / cytosol / extracellular exosome / lysosomal membrane / plasma membrane / vacuolar proton-transporting V-type ATPase, V1 domain
- General Function
- Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.
- Specific Function
- Enzyme regulator activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0052464|V-type proton ATPase subunit H (ATP6V1H) ATGACCAAAATGGATATCCGAGGTGCTGTGGATGCTGCTGTCCCCACCAATATTATTGCT GCCAAGGCTGCAGAAGTTCGTGCAAACAAAGTCAACTGGCAATCCTATCTTCAGGGACAG ATGATTTCTGCTGAAGATTGTGAGTTTATTCAGAGGTTTGAAATGAAACGAAGCCCTGAA GAGAAGCAAGAGATGCTTCAAACTGAAGGCAGCCAGTGTGCTAAAACATTTATAAATCTG ATGACTCATATCTGCAAAGAACAGACCGTTCAGTATATACTAACTATGGTGGATGATATG CTGCAGGAAAATCATCAGCGTGTTAGCATTTTCTTTGACTATGCAAGATGTAGCAAGAAC ACTGCGTGGCCCTACTTTCTGCCAATGTTGAATCGCCAGGATCCCTTCACTGTTCATATG GCAGCAAGAATTATTGCCAAGTTAGCAGCTTGGGGAAAAGAACTGATGGAAGGCAGTGAC TTAAATTACTATTTCAATTGGATAAAAACTCAGCTGAGTTCACAGAAACTGCGTGGTAGC GGTGTTGCTGTTGAAACAGGAACAGTCTCTTCAAGTGATAGTTCGCAGTATGTGCAGTGC GTGGCCGGGTGTTTGCAGCTGATGCTCCGGGTCAATGAGTACCGCTTTGCTTGGGTGGAA GCAGATGGGGTAAATTGCATAATGGGAGTGTTGAGTAACAAGTGTGGCTTTCAGCTCCAG TATCAAATGATTTTTTCAATATGGCTCCTGGCATTCAGTCCTCAAATGTGTGAACACCTG CGGCGCTATAATATCATTCCAGTTCTGTCTGATATCCTTCAGGAGTCTGTCAAAGAGAAA GTAACAAGAATCATTCTTGCAGCATTTCGTAACTTTTTAGAAAAATCAACTGAAAGAGAA ACTCGCCAAGAATATGCCCTGGCTATGATTCAGTGCAAAGTTCTGAAACAGTTGGAGAAC TTGGAACAGCAGAAGTACGATGATGAAGATATCAGCGAAGATATCAAATTTCTTTTGGAA AAACTTGGAGAGAGTGTCCAGGACCTTAGTTCATTTGATGAATACAGTTCAGAACTTAAA TCTGGAAGGTTGGAATGGAGTCCTGTGCACAAATCTGAGAAATTTTGGAGAGAGAATGCT GTGAGGTTAAATGAGAAGAATTATGAACTCTTGAAAATCTTGACAAAACTTTTGGAAGTG TCAGATGATCCCCAAGTCTTAGCTGTTGCTGCTCACGATGTTGGAGAATATGTGCGGCAT TATCCACGAGGCAAACGGGTCATCGAGCAGCTCGGTGGGAAGCAGCTGGTCATGAACCAC ATGCATCATGAAGACCAGCAGGTCCGCTATAATGCTCTGCTGGCCGTGCAGAAGCTCATG GTGCACAACTGGGAATACCTTGGCAAGCAGCTCCAGTCCGAGCAGCCCCAGACCGCTGCC GCCCGAAGCTAA
- Chromosome Location
- 8
- Locus
- 8q11.23
- External Identifiers
Resource Link UniProtKB ID Q9UI12 UniProtKB Entry Name VATH_HUMAN HGNC ID HGNC:18303 - General References
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