Serine/threonine-protein kinase 36
Details
- Name
- Serine/threonine-protein kinase 36
- Synonyms
- 2.7.11.1
- Fused homolog
- KIAA1278
- Gene Name
- STK36
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051654|Serine/threonine-protein kinase 36 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH PNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHR ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHT ADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPR QRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSR ILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILAS ELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEW QHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLS SLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFA CTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGN SRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISS ALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYS CCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGM EKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRL TPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEG ELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLC PSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQV CCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSD LLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHS MALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQL LGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSL QQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM
- Number of residues
- 1315
- Molecular Weight
- 143993.57
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / metal ion binding / protein serine/threonine kinase activity / transcription factor bindingProcessesbrain development / cilium assembly / epithelial cilium movement / positive regulation of hh target transcription factor activity / positive regulation of smoothened signaling pathway / post-embryonic development / protein phosphorylation / regulation of DNA binding transcription factor activityComponentscytoplasm / cytosol / nucleus
- General Function
- Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.
- Specific Function
- Atp binding
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051655|Serine/threonine-protein kinase 36 (STK36) ATGGAAAAGTACCACGTGTTGGAGATGATTGGAGAAGGCTCTTTTGGGAGGGTGTACAAG GGTCGAAGAAAATACAGTGCTCAGGTCGTGGCCCTGAAGTTCATCCCAAAATTGGGGCGC TCAGAGAAGGAGCTGAGGAATTTGCAACGAGAGATTGAAATAATGCGGGGTCTGCGGCAT CCCAACATTGTGCATATGCTTGACAGCTTTGAAACTGATAAAGAGGTGGTGGTGGTGACA GACTATGCTGAGGGAGAGCTCTTTCAGATCCTAGAAGATGACGGAAAACTTCCTGAAGAC CAGGTTCAGGCCATTGCTGCCCAGTTGGTGTCAGCCCTGTACTATCTGCATTCCCACCGC ATCCTACACCGAGATATGAAGCCTCAGAACATCCTCCTCGCCAAGGGTGGTGGCATCAAG CTCTGTGACTTTGGATTTGCCCGGGCTATGAGCACCAATACAATGGTGCTGACATCCATC AAAGGCACACCACTCTATATGTCTCCAGAGCTGGTGGAGGAGCGACCATACGACCACACA GCGGACCTCTGGTCTGTTGGCTGCATACTATATGAACTGGCAGTAGGCACCCCTCCCTTC TATGCTACAAGCATCTTTCAGCTGGTCAGCCTCATTCTCAAGGACCCTGTGCGCTGGCCC TCAACCATCAGTCCCTGCTTTAAGAACTTCCTGCAGGGACTGCTCACCAAAGACCCACGG CAGCGACTGTCCTGGCCAGACCTCTTATATCACCCCTTTATTGCTGGTCATGTCACCATA ATAACTGAGCCAGCAGGCCCAGATTTGGGGACCCCATTCACCAGCCGCCTACCCCCAGAA CTTCAGGTCCTAAAGGACGAACAGGCCCATCGGTTGGCCCCCAAGGGTAATCAGTCTCGC ATCTTGACTCAGGCCTATAAACGCATGGCTGAGGAGGCCATGCAGAAGAAACATCAGAAC ACAGGACCTGCCCTTGAGCAAGAGGACAAGACCAGCAAGGTGGCTCCTGGCACAGCCCCT CTGCCCAGACTCGGGGCCACTCCTCAGGAATCAAGCCTCCTGGCCGGGATCTTAGCCTCA GAATTGAAGAGCAGCTGGGCTAAATCAGGGACTGGAGAGGTGCCCTCTGCACCTCGGGAA AACCGGACCACCCCAGATTGTGAACGAGCATTCCCAGAGGAGAGGCCAGAGGTGCTGGGC CAGCGGAGCACTGATGTAGTGGACCTGGAAAATGAGGAGCCAGACAGTGACAATGAGTGG CAGCACCTGCTAGAGACCACTGAGCCTGTGCCTATTCAACTGAAGGCTCCTCTCACCTTG CTGTGTAATCCTGACTTCTGCCAGCGCATCCAGAGTCAGCTGCATGAAGCTGGAGGGCAG ATCCTGAAAGGCATCTTGGAGGGTGCTTCCCACATCCTGCCTGCATTCCGGGTCCTGAGC AGTCTTCTCTCCAGCTGCAGTGATTCTGTTGCCTTGTATTCCTTCTGCCGGGAGGCAGGG CTTCCTGGGCTGCTGCTGAGTCTACTCAGGCACAGTCAGGAGAGCAACAGCCTCCAGCAG CAATCTTGGTATGGGACCTTCTTACAGGACCTGATGGCTGTGATTCAGGCCTACTTTGCC TGTACCTTCAATCTGGAGAGGAGCCAGACAAGTGACAGCCTGCAGGTGTTTCAGGAGGCT GCCAACCTTTTTCTGGACCTGTTGGGGAAACTGCTGGCCCAACCAGATGACTCTGAGCAG ACTTTGCGGAGGGACAGCCTTATGTGCTTTACTGTCCTGTGCGAAGCCATGGATGGGAAC AGCCGGGCCATCTCCAAAGCCTTTTACTCCAGCTTGCTGACGACACAGCAGGTTGTCTTG GATGGGCTCCTTCATGGCTTGACAGTTCCACAGCTCCCTGTCCACACTCCCCAAGGAGCC CCGCAAGTGAGCCAGCCACTGCGAGAGCAGAGTGAGGATATACCTGGAGCCATTTCCTCT GCCCTGGCAGCCATATGCACTGCTCCTGTGGGACTGCCCGACTGCTGGGATGCCAAGGAG CAGGTCTGTTGGCATTTGGCAAATCAGCTAACTGAAGACAGCAGCCAGCTCAGGCCATCC CTCATCTCTGGCCTGCAGCATCCCATCCTGTGCCTGCACCTTCTCAAGGTTCTATACTCC TGCTGCCTTGTCAGTGAGGGCCTGTGCCGTCTTCTGGGGCAGGAGCCCCTGGCCTTGGAA TCCCTGTTTATGTTGATTCAGGGCAAGGTAAAAGTAGTAGATTGGGAAGAGTCTACTGAA GTGACACTCTACTTCCTCTCCCTTCTTGTCTTTCGGCTCCAAAACCTGCCTTGTGGAATG GAGAAGCTAGGCAGTGACGTTGCTACTCTCTTTACCCATTCGCATGTCGTCTCTCTTGTG AGTGCAGCAGCCTGTCTATTGGGACAGCTTGGTCAGCAAGGGGTGACCTTTGACCTCCAG CCCATGGAATGGATGGCTGCAGCCACACATGCCTTGTCTGCCCCTGCAGAGGTTCGGTTG ACTCCACCAGGTAGTTGTGGATTCTATGATGGCCTCCTTATCCTTCTGTTGCAGCTCCTC ACTGAGCAGGGGAAGGCTAGCCTAATCAGGGATATGTCCAGTTCAGAAATGTGGACCGTT TTGTGGCACCGCTTCTCCATGGTCCTGAGGCTCCCCGAGGAGGCATCTGCACAGGAAGGG GAGCTTTCGCTATCCAGTCCACCAAGCCCTGAGCCAGACTGGACACTGATTTCTCCCCAG GGCATGGCAGCCCTGCTGAGCCTGGCCATGGCCACCTTTACCCAGGAGCCCCAGTTATGC CTGAGCTGCCTGTCCCAGCATGGAAGTATCCTCATGTCCATCCTGAAGCATCTGCTTTGC CCCAGCTTCCTGAATCAACTGCGCCAGGCGCCTCATGGGTCTGAGTTTCTCCCTGTCGTG GTGCTCTCTGTCTGCCAGCTCCTTTGCTTCCCCTTTGCGCTGGACATGGATGCTGACCTC CTTATAGGTGTCTTGGCCGACCTCAGGGACTCAGAAGTTGCAGCCCATCTGCTGCAGGTC TGCTGCTACCATCTTCCGTTGATGCAAGTGGAGCTGCCCATCAGCCTTCTCACACGCCTG GCCCTCATGGATCCCACCTCTCTCAACCAGTTTGTGAACACAGTGTCTGCCTCCCCTAGA ACCATCGTCTCGTTTCTCTCAGTTGCCCTCCTGAGTGACCAGCCACTGTTGACCTCCGAC CTTCTCTCTCTGCTGGCCCATACTGCCAGGGTCCTGTCTCCCAGCCACTTGTCCTTTATC CAAGAGCTTCTGGCTGGCTCTGATGAATCCTATCGGCCCCTGCGCAGCCTCCTGGGCCAC CCAGAGAATTCTGTGCGGGCACACACTTATAGGCTCCTGGGACACTTGCTCCAACACAGC ATGGCCCTGCGTGGGGCACTGCAGAGCCAGTCTGGACTGCTCAGCCTTCTGCTGCTTGGG CTTGGAGACAAGGATCCTGTTGTGCGGTGCAGTGCCAGCTTTGCTGTGGGCAATGCAGCC TACCAGGCTGGTCCTCTGGGACCTGCCCTGGCAGCTGCAGTGCCCAGTATGACCCAGCTG CTTGGAGATCCTCAGGCTGGTATCCGGCGCAATGTTGCATCAGCTCTGGGCAACTTGGGA CCTGAAGGTTTGGGAGAGGAGCTGTTACAGTGCGAAGTACCCCAGCGGCTCCTAGAAATG GCATGTGGAGACCCCCAGCCAAATGTGAAGGAGGCTGCCCTCATTGCCCTCCGGAGCCTG CAACAGGAGCCTGGCATCCATCAGGTACTGGTGTCCCTGGGTGCCAGTGAGAAACTATCC TTGCTCTCTCTGGGGAATCAGTCACTGCCACACAGCAGTCCTAGGCCTGCCTCTGCCAAA CACTGCAGGAAACTCATTCACCTCCTGAGGCCAGCCCATAGCATGTGA
- Chromosome Location
- 2
- Locus
- 2q35
- External Identifiers
Resource Link UniProtKB ID Q9NRP7 UniProtKB Entry Name STK36_HUMAN HGNC ID HGNC:17209 - General References
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