Retinol dehydrogenase 14
Details
- Name
- Retinol dehydrogenase 14
- Synonyms
- 1.1.1.-
- Alcohol dehydrogenase PAN2
- PAN2
- SDR7C4
- Short chain dehydrogenase/reductase family 7C member 4
- Gene Name
- RDH14
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016751|Retinol dehydrogenase 14 MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATA AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLR SVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLK SSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV TVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSG RYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK
- Number of residues
- 336
- Molecular Weight
- 36864.355
- Theoretical pI
- 9.0
- GO Classification
- Functionsalcohol dehydrogenase (NADP+) activityProcessesosteoblast differentiation / retinol metabolic processComponentsendoplasmic reticulum / endoplasmic reticulum membrane / lysosomal membrane / membrane / mitochondrion / nucleus
- General Function
- Alcohol dehydrogenase (nadp+) activity
- Specific Function
- Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016752|Retinol dehydrogenase 14 (RDH14) ATGGCAGTGGCCACTGCGGCGGCAGTACTGGCCGCTCTGGGCGGGGCGCTGTGGCTGGCG GCCCGCCGGTTCGTGGGGCCCAGGGTCCAGCGGCTGCGCAGAGGCGGGGACCCCGGCCTC ATGCACGGGAAGACTGTGCTGATCACCGGGGCGAACAGCGGCCTGGGCCGCGCCACGGCC GCCGAGCTACTGCGCCTGGGAGCGCGGGTGATCATGGGCTGCCGGGACCGCGCGCGCGCC GAGGAGGCGGCGGGTCAGCTCCGCCGCGAGCTCCGCCAGGCCGCGGAGTGCGGCCCAGAG CCTGGCGTCAGCGGGGTGGGCGAGCTCATAGTCCGGGAGCTGGACCTCGCCTCGCTGCGC TCGGTGCGCGCCTTCTGCCAGGAAATGCTCCAGGAAGAGCCTAGGCTGGATGTCTTGATC AATAACGCAGGGATCTTCCAGTGCCCTTACATGAAGACTGAAGATGGGTTTGAGATGCAG TTCGGAGTGAACCATCTGGGGCACTTTCTACTCACCAATCTTCTCCTTGGACTCCTCAAA AGTTCAGCTCCCAGCAGGATTGTGGTAGTTTCTTCCAAACTTTATAAATACGGAGACATC AATTTTGATGACTTGAACAGTGAACAAAGCTATAATAAAAGCTTTTGTTATAGCCGGAGC AAACTGGCTAACATTCTTTTTACCAGGGAACTAGCCCGCCGCTTAGAAGGCACAAATGTC ACCGTCAATGTGTTGCATCCTGGTATTGTACGGACAAATCTGGGGAGGCACATACACATT CCACTGTTGGTCAAACCACTCTTCAATTTGGTGTCATGGGCTTTTTTCAAAACTCCAGTA GAAGGTGCCCAGACTTCCATTTATTTGGCCTCTTCACCTGAGGTAGAAGGAGTGTCAGGA AGATACTTTGGGGATTGTAAAGAGGAAGAACTGTTGCCCAAAGCTATGGATGAATCTGTT GCAAGAAAACTCTGGGATATCAGTGAAGTGATGGTTGGCCTGCTAAAATAG
- Chromosome Location
- 2
- Locus
- 2p24.2
- External Identifiers
Resource Link UniProtKB ID Q9HBH5 UniProtKB Entry Name RDH14_HUMAN GenBank Protein ID 10039619 GenBank Gene ID AF237952 GenAtlas ID RDH14 HGNC ID HGNC:19979 - General References
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