Estrogen receptor beta
Details
- Name
- Estrogen receptor beta
- Synonyms
- ER-beta
- ESTRB
- NR3A2
- Nuclear receptor subfamily 3 group A member 2
- Gene Name
- ESR2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001580|Estrogen receptor beta MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
- Number of residues
- 530
- Molecular Weight
- 59215.765
- Theoretical pI
- 8.55
- GO Classification
- Functionscore promoter sequence-specific DNA binding / DNA binding / enzyme binding / estrogen receptor activity / estrogen response element binding / receptor antagonist activity / RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding / steroid binding / steroid hormone receptor activity / transcription coactivator activity / transcription factor activity, sequence-specific DNA binding / zinc ion bindingProcessescell-cell signaling / extracellular negative regulation of signal transduction / gene expression / intracellular estrogen receptor signaling pathway / negative regulation of cell growth / negative regulation of transcription from RNA polymerase II promoter / positive regulation of sequence-specific DNA binding transcription factor activity / positive regulation of transcription, DNA-templated / regulation of transcription, DNA-templated / signal transduction / transcription initiation from RNA polymerase II promoterComponentsextracellular region / mitochondrion / nucleoplasm / nucleus
- General Function
- Zinc ion binding
- Specific Function
- Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0020485|Estrogen receptor beta (ESR2) ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG CTCCTGTCCCACGTCAGGCATGCGAGGGCAGAAAAGGCCTCTCAAACACTCACCTCATTT GGAATGAAGATGGAGACTCTTTTGCCTGAAGCAACGATGGAGCAGTGA
- Chromosome Location
- 14
- Locus
- 14q23.2
- External Identifiers
Resource Link UniProtKB ID Q92731 UniProtKB Entry Name ESR2_HUMAN GenBank Protein ID 2911152 GenBank Gene ID AB006590 GenAtlas ID ESR2 HGNC ID HGNC:3468 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01196 Estramustine approved, investigational yes other/unknown Details DB00481 Raloxifene approved, investigational yes agonist Details DB00783 Estradiol approved, investigational, vet_approved yes agonist Details DB01108 Trilostane approved, investigational, vet_approved, withdrawn yes allosteric modulator Details DB01645 Genistein investigational unknown Details DB04020 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol experimental unknown Details DB02983 Para-Mercury-Benzenesulfonic Acid experimental unknown Details DB03860 ICI-164384 experimental unknown Details DB00675 Tamoxifen approved yes antagonistagonist Details DB04468 Afimoxifene investigational unknown Details DB05052 MF101 investigational unknown Details DB05882 CHF 4227 investigational unknown Details DB05966 TAS-108 investigational unknown Details DB06202 Lasofoxifene approved, investigational yes agonist Details DB06249 Arzoxifene approved, investigational unknown Details DB06832 Prinaberel investigational unknown Details DB06875 ERB-196 experimental unknown Details DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE experimental unknown Details DB06937 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL experimental unknown Details DB07009 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL experimental unknown Details DB07032 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL experimental unknown Details DB07036 (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol experimental unknown Details DB07119 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL experimental unknown Details DB07150 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME experimental unknown Details DB07198 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE experimental unknown Details DB07230 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE experimental unknown Details DB07236 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL experimental unknown Details DB07638 (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL experimental unknown Details DB07702 17alpha-Estriol experimental unknown Details DB07757 (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one experimental unknown Details DB07933 Erteberel experimental, investigational unknown Details DB08020 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL experimental unknown Details DB04573 Estriol approved, investigational, vet_approved unknown agonist Details DB00255 Diethylstilbestrol approved, investigational, withdrawn yes agonist Details DB04574 Estrone sulfate approved unknown agonist Details DB03882 5-Alpha-Androstane-3-Beta,17beta-Diol experimental unknown agonist Details DB01708 Prasterone approved, investigational, nutraceutical unknown activator Details DB04216 Quercetin experimental, investigational unknown Details DB00655 Estrone approved unknown Details DB09086 Eugenol approved unknown Details DB11674 Equol investigational unknown agonist Details DB02746 Phthalic Acid experimental unknown Details DB06401 Bazedoxifene approved, investigational unknown Details DB01878 Benzophenone experimental unknown Details DB11219 Enzacamene approved unknown Details DB09535 Octocrylene approved, investigational unknown Details DB01428 Oxybenzone approved, investigational unknown Details DB02757 Pyrazole experimental unknown Details DB03467 Naringenin experimental unknown partial agonist Details DB13869 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol experimental unknown Details DB13952 Estradiol acetate approved, investigational, vet_approved yes agonist Details DB13953 Estradiol benzoate approved, investigational, vet_approved yes agonist Details DB13954 Estradiol cypionate approved, investigational, vet_approved yes agonist Details DB13955 Estradiol dienanthate approved, investigational, vet_approved yes agonist Details DB13956 Estradiol valerate approved, investigational, vet_approved yes agonist Details DB14641 Estriol tripropionate experimental unknown Details DB00286 Conjugated estrogens approved yes agonist Details DB00396 Progesterone approved, vet_approved unknown agonistdownregulator Details DB15690 Fluoroestradiol F-18 approved unknown binder Details DB12235 Estetrol approved, investigational unknown agonist Details DB13310 Ormeloxifene experimental unknown modulator Details DB00421 Spironolactone approved unknown agonist Details