Calcium-dependent secretion activator 2
Details
- Name
- Calcium-dependent secretion activator 2
- Synonyms
- Calcium-dependent activator protein for secretion 2
- CAPS-2
- CAPS2
- KIAA1591
- Gene Name
- CADPS2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049518|Calcium-dependent secretion activator 2 MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPS PSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKLNKQQLQ LLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKN IEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLY EMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKD MENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSD VVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHP RPVVKVKLFTESTGVLALEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAV RMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEG YTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQ TQKLNPKGGTLHADAQLSGKDADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLN DSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAF CASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLS LLERVLMKDIATPIPAEEVKKVVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEI LHLAELCIEVLQQNEEHHAEGREAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWD SFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQ PVKNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYESTNGSATSEDLFWKLDALQ MFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVC TMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSK LSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIE KLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTY DTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG
- Number of residues
- 1296
- Molecular Weight
- 147733.365
- Theoretical pI
- Not Available
- GO Classification
- Functionslipid binding / metal ion bindingProcessescellular response to starvation / dense core granule exocytosis / positive regulation of exocytosis / protein transport / synaptic vesicle primingComponentscell junction / cytoplasmic vesicle membrane / intracellular membrane-bounded organelle / nucleoplasm / postsynaptic membrane / presynaptic membrane
- General Function
- Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).
- Specific Function
- Lipid binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic vesicle membrane
- Gene sequence
>lcl|BSEQ0049519|Calcium-dependent secretion activator 2 (CADPS2) ATGCTGGACCCGTCTTCCAGCGAAGAGGAGTCGGACGAGGGGCTGGAAGAGGAAAGCCGC GATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGG CGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGAGC CCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAG CGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAAC GCCAAGCAGCCCACCGACATGGCCCGGAGGCAGCAGAAGCTTAACAAACAACAGTTGCAG TTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGAA GCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCC AGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAAC ATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTTG AGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAG CCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTAT GAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGCA TGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGG CTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGAT ATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTTG GAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCA CAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGAC GTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGTT GCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGAC CAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCT CGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGAT AAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTA CACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTG CGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAAG GTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTT GCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGC TATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAAT GCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTA TGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAA ACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTCTGGTAAA GATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAG CTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCAGACTTTGGATCACAGACTGAAT GATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTAC TGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATG GAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGCATTC TGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAA AAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGC CATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACTTTCA TTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAG AAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAA TATGCCAAAATAGAAGAGACCATGAACCAGGCATCTCCTGCTAGAAAGCTGGAAGAGATT CTTCATCTGGCAGAGCTCTGCATAGAAGTCTTACAGCAGAATGAAGAGCATCATGCAGAG GGAAGAGAGGCATTTGCCTGGTGGCCTGATTTATTGGCTGAACATGCAGAGAAATTTTGG GCTTTATTTACAGTGGATATGGACACTGCACTAGAGGCTCAACCGCAAGACTCCTGGGAT AGTTTTCCTCTTTTCCAACTGCTTAATAATTTCCTCCGAAATGACACACTTTTGTGTAAT GGAAAATTTCACAAACACTTGCAAGAAATCTTTGTACCCTTGGTTGTCCGCTATGTGGAT CTCATGGAGTCTTCCATCGCCCAGTCAATTCACAGAGGTTTTGAGCAGGAGACATGGCAG CCTGTCAAGAATATCGCCAACAGTCTTCCCAATGTAGCTCTTCCAAAAGTTCCAAGTCTG CCTCTTAATCTTCCACAGATTCCTAACATTTCTACTGCTTCGTGGATGCCTTCTTTATAT GAGTCCACCAATGGCTCAGCAACATCAGAAGACCTTTTTTGGAAGCTTGATGCACTGCAA ATGTTTGTCTTTGATCTGCACTGGCCAGAACAGGAATTTGCCCACCACTTAGAGCAAAGA CTTAAACTAATGGCCAGTGATATGCTAGAGGCCTGTGTCAAAAGAACAAGAACTGCATTT GAACTCAAGCTACAAAAGGCAAGCAAAACAACTGACTTGCGCATTCCAGCTTCCGTTTGC ACTATGTTTAATGTATTAGTCGATGCCAAAAAGCAAAGCACCAAACTCTGTGCCCTGGAT GGAGGACAAGAGCAACAGTACCATTCAAAAATAGATGATCTGATCGACAACAGTGTAAAA GAAATCATTTCACTGTTAGTTTCAAAGTTTGTTTCAGTGTTGGAAGGCGTGTTGTCTAAG CTGTCAAGGTATGATGAAGGCACTTTCTTTTCATCCATTCTGTCATTCACTGTGAAAGCA GCTGCAAAATATGTTGATGTTCCAAAACCAGGAATGGATCTGGCAGACACCTATATTATG TTTGTTCGGCAAAACCAAGATATTCTTCGAGAAAAGGTCAATGAGGAAATGTATATAGAA AAGTTATTTGATCAATGGTACAGCAGTTCCATGAAAGTCATTTGCGTGTGGTTGACTGAT AGATTAGACCTCCAACTCCATATTTACCAGCTGAAGACGCTCATCAAGATTGTGAAGAAA ACCTACAGGGACTTTCGATTGCAGGGTGTGTTGGAAGGAACACTGAACAGTAAGACTTAT GATACTGTGCACAGACGTTTAACAGTAGAGGAGGCCACAGCCTCTGTTTCAGAAGGAGGA GGACTTCAGGGCATTACTATGAAAGACAGTGACGAAGAAGAAGAAGGCTGA
- Chromosome Location
- 7
- Locus
- 7q31.32
- External Identifiers
Resource Link UniProtKB ID Q86UW7 UniProtKB Entry Name CAPS2_HUMAN HGNC ID HGNC:16018 - General References
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