Mitogen-activated protein kinase kinase kinase 15
Details
- Name
- Mitogen-activated protein kinase kinase kinase 15
- Synonyms
- 2.7.11.25
- Apoptosis signal-regulating kinase 3
- ASK3
- MAPK/ERK kinase kinase 15
- MEK kinase 15
- MEKK 15
- Gene Name
- MAP3K15
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051810|Mitogen-activated protein kinase kinase kinase 15 MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRA LRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDA DVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGN YYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSC VYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDA MVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDM FCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETS LELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVW YLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVY QPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNS DDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGK GTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENG YIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVL VNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCT IIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTA ELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPD ALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILW EEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDF DSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFE PTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKERE YQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEK IVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA
- Number of residues
- 1313
- Molecular Weight
- 147435.68
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / MAP kinase kinase kinase activity / metal ion bindingProcessesactivation of MAPKK activityComponentsintracellular
- General Function
- May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051811|Mitogen-activated protein kinase kinase kinase 15 (MAP3K15) ATGGAGAGCGGCGGTGGGAATGCTCCGGCCGGGGCCCTCGGGGCGGCGAGCGAGTCCCCT CAGTGCCCGCCGCCGCCGGGGGTGGAGGGCGCGGCCGGGCCGGCGGAGCCCGACGGGGCG GCGGAGGGCGCGGCAGGCGGCAGCGGCGAGGGCGAGAGTGGGGGCGGGCCGCGGCGGGCT CTGCGGGCAGTATACGTGCGCAGTGAGAGCTCCCAGGGCGGCGCGGCCGGCGGCCCGGAG GCTGGGGCGCGGCAGTGCCTGCTGCGGGCCTGCGAGGCCGAGGGCGCTCACCTCACCTCC GTGCCCTTCGGGGAGCTGGACTTCGGGGAGACGGCCGTGCTCGACGCCTTCTACGACGCA GATGTTGCTGTGGTAGACATGAGCGATGTCTCCAGACAGCCTTCCCTCTTCTACCATCTT GGAGTCCGAGAAAGCTTTGACATGGCCAATAATGTGATCTTGTACCATGACACCGATGCC GACACTGCTCTCTCTTTGAAGGACATGGTAACTCAAAAAAACACAGCATCCAGTGGAAAT TATTATTTCATCCCATACATCGTGACACCGTGCGCTGATTATTTTTGCTGCGAGAGTGAT GCCCAGAGACGAGCCTCCGAGTACATGCAGCCCAACTGGGACAACATCCTGGGCCCGCTG TGCATGCCTTTGGTGGACAGGTTCATTAGCCTCCTTAAGGACATCCACGTGACCTCATGT GTTTATTACAAAGAAACCTTGTTAAATGACATCCGGAAAGCCAGAGAGAAATACCAAGGT GAGGAACTGGCGAAGGAGCTAGCTCGGATCAAGCTCCGCATGGATAATACTGAGGTTCTG ACCTCAGACATCATCATTAACTTACTCCTGTCCTACCGTGATATCCAGGACTATGATGCG ATGGTGAAGCTGGTGGAAACACTGGAGATGCTGCCTACGTGTGATTTGGCCGATCAGCAT AACATTAAATTCCACTATGCGTTTGCACTGAATAGGAGAAACAGCACAGGTGACCGTGAG AAGGCTCTGCAGATCATGCTCCAGGTTCTGCAGAGCTGTGATCACCCGGGCCCCGACATG TTCTGCCTGTGTGGGAGGATCTACAAGGACATCTTCTTGGATTCAGACTGCAAAGATGAC ACCAGCCGCGACAGCGCCATTGAGTGGTATCGCAAAGGGTTTGAACTCCAGTCATCCCTC TATTCGGGAATTAATCTTGCAGTTTTGCTGATTGTTGCTGGACAACAATTTGAAACTTCC TTGGAACTAAGGAAAATAGGTGTCCGGCTGAACAGTTTGTTGGGAAGAAAAGGGAGCTTG GAGAAAATGAACAATTACTGGGATGTGGGTCAGTTCTTCAGCGTCAGCATGCTGGCCCAT GATGTCGGGAAAGCCGTCCAGGCAGCAGAGAGGTTGTTCAAACTGAAACCTCCAGTCTGG TACCTGCGATCATTAGTTCAGAACTTGTTACTAATTCGGCGCTTCAAGAAAACCATTATT GAACACTCGCCCAGGCAAGAGCGGCTGAACTTCTGGTTAGATATAATTTTTGAGGCAACA AATGAAGTCACTAATGGACTCAGATTTCCAGTTCTGGTCATAGAGCCAACCAAAGTGTAC CAGCCTTCTTATGTTTCCATAAACAATGAAGCCGAGGAGAGAACAGTTTCTTTATGGCAT GTCTCACCCACAGAAATGAAACAGATGCACGAATGGAATTTTACAGCCTCTTCCATAAAG GGAATAAGCCTATCAAAGTTTGATGAAAGGTGTTGTTTTCTTTATGTCCATGATAATTCT GATGACTTTCAAATCTACTTTTCCACCGAAGAGCAGTGCAGTAGATTTTTCTCTTTGGTC AAAGAGATGATAACCAATACAGCAGGCAGTACGGTGGAGCTGGAGGGAGAGACCGATGGA GACACCTTGGAGTATGAGTATGACCATGATGCAAATGGTGAGAGAGTTGTCTTGGGGAAA GGCACGTATGGGATTGTGTATGCTGGCCGAGATCTGAGCAATCAAGTGCGAATAGCCATC AAAGAAATCCCGGAGAGAGATAGCAGGTATTCTCAGCCTCTGCACGAGGAGATAGCCCTG CACAAGTACCTTAAGCACCGCAATATCGTTCAGTACCTGGGCTCTGTTTCAGAGAACGGC TACATTAAGATATTTATGGAGCAGGTGCCTGGAGGAAGCCTTTCTGCTCTTCTGCGATCC AAATGGGGGCCGATGAAGGAACCGACAATCAAGTTTTACACCAAACAGATCCTGGAGGGC CTTAAGTATCTTCATGAAAACCAGATCGTGCACAGAGACATAAAGGGCGATAATGTTCTG GTGAACACCTACAGCGGAGTGGTGAAAATCTCCGATTTTGGAACCTCGAAACGTCTTGCG GGTGTGAACCCCTGCACAGAGACTTTTACTGGCACCCTGCAGTACATGGCACCTGAGATA ATTGACCAAGGGCCTCGCGGATATGGTGCCCCAGCCGATATCTGGTCCCTGGGCTGCACC ATCATTGAGATGGCCACCAGCAAGCCTCCGTTCCATGAGCTTGGTGAGCCGCAGGCAGCC ATGTTCAAAGTGGGCATGTTTAAGATCCACCCTGAGATTCCAGAAGCCCTTTCAGCTGAA GCCCGAGCCTTCATTTTATCCTGTTTCGAGCCTGACCCCCACAAACGTGCCACCACTGCT GAGCTACTGAGAGAGGGTTTCTTAAGGCAGGTGAACAAGGGCAAGAAGAACCGAATTGCC TTCAAGCCCTCAGAAGGTCCCCGCGGTGTCGTCCTGGCCCTGCCCACACAGGGAGAGCCC ATGGCCACCAGCAGCAGCGAGCACGGCTCTGTCTCCCCAGACTCCGACGCCCAGCCTGAC GCACTCTTTGAGAGGACCCGGGCGCCCAGGCACCACCTTGGCCACCTCCTCAGTGTTCCA GACGAGAGCTCAGCCTTGGAAGACCGGGGCTTGGCCTCGTCCCCGGAGGACAGGGACCAG GGCCTCTTCCTGCTACGCAAGGACAGTGAGCGCCGTGCCATCCTGTACAAAATCCTCTGG GAGGAGCAGAACCAGGTGGCTTCCAACCTGCAGGAGTGTGTGGCCCAGAGTTCCGAAGAG TTGCATCTCTCAGTTGGACACATCAAGCAAATCATTGGGATCCTGAGGGACTTCATCCGC TCCCCAGAGCACCGGGTGATGGCGACCACAATATCAAAGCTCAAGGTGGACCTGGACTTT GACAGCTCGTCCATCAGTCAGATTCACCTGGTGCTGTTCGGATTTCAGGATGCCGTAAAT AAAATTTTGAGGAACCACTTAATTAGGCCCCACTGGATGTTCGCGATGGACAACATCATC CGCCGAGCGGTGCAGGCCGCGGTCACCATTCTCATCCCAGAGCTCCGAGCCCACTTTGAG CCTACCTGTGAGACTGAAGGGGTAGATAAGGACATGGATGAAGCGGAAGAGGGCTATCCC CCAGCCACCGGACCTGGCCAGGAGGCCCAGCCCCACCAGCAGCACCTGAGCCTCCAGCTG GGTGAGCTCAGACAGGAGACCAACAGACTTTTGGAACACCTAGTTGAAAAAGAGAGAGAG TACCAGAATCTTCTGCGGCAAACTCTAGAACAGAAAACTCAAGAATTGTATCACCTTCAG TTAAAATTAAAATCGAATTGTATTACAGAGAACCCAGCAGGCCCCTACGGGCAGAGAACA GATAAAGAGCTTATAGACTGGTTGCGGCTGCAAGGAGCTGATGCAAAGACAATTGAAAAG ATTGTTGAAGAGGGTTATACACTTTCGGATATTCTTAATGAGATCACTAAGGAAGATCTA AGATACCTTCGACTACGGGGTGGTCTCCTCTGCAGACTCTGGAGTGCGGTCTCCCAGTAC AGAAGGGCTCAGGAGGCCTCAGAAACCAAAGACAAGGCTTGA
- Chromosome Location
- X
- Locus
- Xp22.12
- External Identifiers
Resource Link UniProtKB ID Q6ZN16 UniProtKB Entry Name M3K15_HUMAN HGNC ID HGNC:31689 - General References
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