Carbonic anhydrase 9
Details
- Name
- Carbonic anhydrase 9
- Synonyms
- 4.2.1.1
- CA-IX
- CAIX
- Carbonate dehydratase IX
- Carbonic anhydrase IX
- G250
- Membrane antigen MN
- MN
- P54/58N
- pMW1
- RCC-associated antigen G250
- Renal cell carcinoma-associated antigen G250
- Gene Name
- CA9
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011744|Carbonic anhydrase 9 MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
- Number of residues
- 459
- Molecular Weight
- 49697.36
- Theoretical pI
- 4.36
- GO Classification
- Functionscarbonate dehydratase activity / zinc ion bindingProcessesbicarbonate transport / cellular response to hypoxia / morphogenesis of an epithelium / one-carbon metabolic process / regulation of transcription from RNA polymerase II promoter in response to hypoxia / response to drug / response to testosterone / secretion / small molecule metabolic processComponentsbasolateral plasma membrane / integral component of membrane / microvillus membrane / nucleolus / plasma membrane
- General Function
- Zinc ion binding
- Specific Function
- Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
- Pfam Domain Function
- Carb_anhydrase (PF00194)
- Transmembrane Regions
- 415-435
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0011745|Carbonic anhydrase 9 (CA9) ATGGCTCCCCTGTGCCCCAGCCCCTGGCTCCCTCTGTTGATCCCGGCCCCTGCTCCAGGC CTCACTGTGCAACTGCTGCTGTCACTGCTGCTTCTGGTGCCTGTCCATCCCCAGAGGTTG CCCCGGATGCAGGAGGATTCCCCCTTGGGAGGAGGCTCTTCTGGGGAAGATGACCCACTG GGCGAGGAGGATCTGCCCAGTGAAGAGGATTCACCCAGAGAGGAGGATCCACCCGGAGAG GAGGATCTACCTGGAGAGGAGGATCTACCTGGAGAGGAGGATCTACCTGAAGTTAAGCCT AAATCAGAAGAAGAGGGCTCCCTGAAGTTAGAGGATCTACCTACTGTTGAGGCTCCTGGA GATCCTCAAGAACCCCAGAATAATGCCCACAGGGACAAAGAAGGGGATGACCAGAGTCAT TGGCGCTATGGAGGCGACCCGCCCTGGCCCCGGGTGTCCCCAGCCTGCGCGGGCCGCTTC CAGTCCCCGGTGGATATCCGCCCCCAGCTCGCCGCCTTCTGCCCGGCCCTGCGCCCCCTG GAACTCCTGGGCTTCCAGCTCCCGCCGCTCCCAGAACTGCGCCTGCGCAACAATGGCCAC AGTGTGCAACTGACCCTGCCTCCTGGGCTAGAGATGGCTCTGGGTCCCGGGCGGGAGTAC CGGGCTCTGCAGCTGCATCTGCACTGGGGGGCTGCAGGTCGTCCGGGCTCGGAGCACACT GTGGAAGGCCACCGTTTCCCTGCCGAGATCCACGTGGTTCACCTCAGCACCGCCTTTGCC AGAGTTGACGAGGCCTTGGGGCGCCCGGGAGGCCTGGCCGTGTTGGCCGCCTTTCTGGAG GAGGGCCCGGAAGAAAACAGTGCCTATGAGCAGTTGCTGTCTCGCTTGGAAGAAATCGCT GAGGAAGGCTCAGAGACTCAGGTCCCAGGACTGGACATATCTGCACTCCTGCCCTCTGAC TTCAGCCGCTACTTCCAATATGAGGGGTCTCTGACTACACCGCCCTGTGCCCAGGGTGTC ATCTGGACTGTGTTTAACCAGACAGTGATGCTGAGTGCTAAGCAGCTCCACACCCTCTCT GACACCCTGTGGGGACCTGGTGACTCTCGGCTACAGCTGAACTTCCGAGCGACGCAGCCT TTGAATGGGCGAGTGATTGAGGCCTCCTTCCCTGCTGGAGTGGACAGCAGTCCTCGGGCT GCTGAGCCAGTCCAGCTGAATTCCTGCCTGGCTGCTGGTGACATCCTAGCCCTGGTTTTT GGCCTCCTTTTTGCTGTCACCAGCGTCGCGTTCCTTGTGCAGATGAGAAGGCAGCACAGA AGGGGAACCAAAGGGGGTGTGAGCTACCGCCCAGCAGAGGTAGCCGAGACTGGAGCCTAG
- Chromosome Location
- 9
- Locus
- 9p13-p12
- External Identifiers
Resource Link UniProtKB ID Q16790 UniProtKB Entry Name CAH9_HUMAN GenBank Gene ID X66839 GenAtlas ID CA9 HGNC ID HGNC:1383 - General References
- Pastorek J, Pastorekova S, Callebaut I, Mornon JP, Zelnik V, Opavsky R, Zat'ovicova M, Liao S, Portetelle D, Stanbridge EJ, et al.: Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Oncogene. 1994 Oct;9(10):2877-88. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB05304 Girentuximab investigational unknown Details DB00562 Benzthiazide approved unknown inhibitor Details DB00774 Hydroflumethiazide approved, investigational, withdrawn unknown inhibitor Details DB00909 Zonisamide approved, investigational unknown inhibitor Details DB08846 Ellagic acid investigational unknown inhibitor Details DB09460 Sodium carbonate approved unknown inhibitor Details DB12741 DTP-348 investigational yes inhibitor Details DB00562 Benzthiazide approved yes inhibitor Details DB00606 Cyclothiazide approved yes inhibitor Details