Inactive phospholipase C-like protein 1
Details
- Name
- Inactive phospholipase C-like protein 1
- Synonyms
- Phospholipase C-deleted in lung carcinoma
- Phospholipase C-related but catalytically inactive protein
- PLC-L1
- PRIP
- Gene Name
- PLCL1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037121|Inactive phospholipase C-like protein 1 MAEGAAGREDPAPPDAAGGEDDPRVGPDAAGDCVTAASGGRMRDRRSGVALPGAAGTPAD SEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSANDCISFMQAGCE LKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGL ADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPR FMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTE EEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRY ELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIED QFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAF VASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVK GKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDF ELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFW NCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSP LALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDE TFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVT LFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDM RENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAI PDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKL NKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEAKSKRSL EAIEEKESSEENGKL
- Number of residues
- 1095
- Molecular Weight
- 122726.98
- Theoretical pI
- 5.26
- GO Classification
- Functionsinositol 1,4,5 trisphosphate binding / phosphatidylinositol phospholipase C activity / phospholipase C activity / signal transducer activityProcessesgamma-aminobutyric acid signaling pathway / intracellular signal transduction / lipid metabolic process / positive regulation of receptor binding / regulation of peptidyl-serine phosphorylation / regulation of synaptic transmission, GABAergicComponentscytoplasm / plasma membrane
- General Function
- Signal transducer activity
- Specific Function
- Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010758|Inactive phospholipase C-like protein 1 (PLCL1) ATGGCCGAGGGCGCGGCCGGCAGGGAGGATCCGGCGCCGCCCGACGCGGCGGGGGGCGAA GACGACCCCCGAGTGGGCCCGGATGCCGCCGGGGACTGCGTGACGGCGGCCTCTGGGGGC CGGATGAGGGACCGTCGCAGCGGGGTCGCACTGCCAGGCGCCGCGGGGACCCCAGCGGAC AGCGAGGCGGGCCTCCTGGAGGCAGCACGGGCGACCCCCCGGCGCAGCAGCATCATCAAG GATCCTTCAAACCAAAAATGTGGTGGAAGAAAGAAAACCGTGTCTTTCAGCAGCATGCCA TCGGAAAAGAAAATTAGCAGTGCAAATGACTGCATCAGCTTCATGCAAGCTGGCTGTGAG TTGAAGAAAGTCCGGCCAAATTCTCGCATTTACAACCGTTTTTTCACTCTGGACACAGAC CTTCAAGCTCTTCGCTGGGAACCTTCAAAGAAAGACCTCGAGAAAGCCAAGCTTGATATT TCTGCCATAAAAGAGATCAGACTGGGGAAAAACACGGAAACATTTAGAAACAATGGCCTT GCTGACCAGATCTGTGAGGACTGTGCCTTTTCCATACTCCACGGGGAAAACTATGAGTCT CTGGACCTAGTTGCCAATTCAGCAGATGTGGCAAACATCTGGGTGTCTGGGTTACGGTAC CTGGTTTCTCGAAGTAAGCAGCCTCTTGATTTTATGGAGGGCAACCAGAACACACCACGG TTCATGTGGTTGAAAACAGTGTTTGAAGCAGCAGATGTTGATGGGAATGGGATTATGTTG GAAGACACCTCTGTAGAGTTAATAAAACAACTCAACCCTACTCTGAAGGAAGCCAAGATC AGGTTAAAGTTTAAAGAAATCCAGAAGAGCAAGGAAAAACTAACCACCCGCGTGACCGAA GAGGAATTTTGTGAAGCTTTTTGTGAACTTTGCACCAGGCCAGAAGTGTATTTCTTACTT GTACAGATATCTAAAAACAAAGAATATTTGGATGCCAATGATCTCATGCTCTTTTTAGAA GCTGAGCAAGGAGTCACCCATATCACCGAGGATATATGCTTAGACATCATAAGGAGATAC GAACTTTCTGAAGAGGGACGTCAAAAAGGGTTTCTTGCAATTGATGGCTTTACCCAGTAT TTATTGTCATCAGAATGTGACATTTTTGATCCTGAGCAAAAGAAGGTTGCCCAAGATATG ACCCAGCCATTATCTCACTACTATATCAATGCCTCTCATAACACCTATCTAATAGAAGAC CAGTTCAGGGGGCCAGCTGACATCAATGGGTACATTAGAGCTTTGAAAATGGGCTGTCGA AGCGTTGAACTCGATGTAAGTGATGGTTCAGATAATGAACCAATCCTTTGTAATCGAAAT AACATGACAACCCATGTTTCCTTTCGAAGTGTCATAGAGGTAATAAATAAATTTGCCTTT GTTGCTTCTGAATACCCACTCATTCTTTGCTTGGGAAATCACTGCTCCTTGCCGCAGCAG AAGGTAATGGCTCAACAGATGAAAAAGGTCTTTGGCAATAAACTCTATACTGAAGCACCT TTGCCCTCAGAATCCTACCTCCCATCACCAGAAAAATTAAAAAGAATGATCATTGTGAAA GGAAAGAAGTTGCCTTCTGATCCAGATGTGTTAGAAGGAGAAGTAACAGATGAAGATGAA GAAGCTGAAATGTCTCGAAGGATGTCGGTAGATTACAATGGTGAGCAGAAGCAAATCCGA CTCTGTAGGGAGCTCTCTGATTTGGTGTCTATTTGTAAATCTGTTCAATACAGGGATTTT GAACTATCTATGAAAAGCCAAAACTATTGGGAAATGTGTTCATTTAGTGAAACAGAGGCC AGCCGCATTGCAAATGAGTACCCAGAGGATTTTGTTAATTATAATAAGAAGTTCTTATCA AGAATCTATCCAAGTGCCATGAGGATCGATTCCAGTAACTTGAATCCACAGGACTTTTGG AATTGTGGCTGTCAGATTGTAGCAATGAATTTTCAGACTCCGGGTCCAATGATGGACCTT CACACGGGCTGGTTTCTTCAAAACGGGGGATGTGGTTATGTTCTAAGGCCGTCTATAATG CGAGATGAAGTTTCTTACTTCAGCGCAAATACAAAGGGCATTCTACCTGGGGTGTCTCCT CTAGCTCTTCATATCAAGATCATCAGTGGTCAGAATTTCCCAAAGCCCAAGGGAGCTTGT GCCAAAGGGGATGTCATAGATCCCTATGTTTGTATAGAGATACACGGAATTCCAGCGGAT TGTTCGGAACAAAGAACTAAAACTGTACAGCAAAACAGTGATAATCCTATTTTTGATGAA ACTTTTGAGTTCCAAGTAAACCTACCTGAGCTGGCCATGATCCGTTTTGTTGTTCTGGAT GATGACTACATTGGGGATGAGTTTATAGGGCAATATACGATACCATTTGAATGTTTGCAG CCTGGATATCGGCATGTTCCCCTGCGTTCTTTTGTGGGTGACATCATGGAGCACGTAACC CTTTTTGTCCACATAGCAATAACTAATCGAAGTGGAGGAGGAAAGGCACAGAAGCGCAGT CTTTCAGTGAGAATGGGGAAGAAAGTTCGGGAATATACCATGCTCAGGAATATCGGTCTT AAAACCATTGATGACATCTTTAAAATAGCGGTTCATCCATTACGAGAAGCCATAGATATG AGAGAAAATATGCAGAATGCAATCGTGTCTATTAAGGAACTATGTGGACTCCCTCCAATT GCCAGTCTGAAGCAGTGCCTGTTAACTCTGTCATCTCGGCTCATCACCAGTGACAATACT CCTTCAGTCTCACTTGTGATGAAAGACAGCTTTCCTTACCTGGAGCCTCTGGGTGCAATT CCAGATGTGCAGAAAAAGATGCTGACTGCTTATGATCTGATGATTCAAGAGAGCCGGTTT CTCATAGAAATGGCGGACACAGTCCAGGAAAAGATTGTACAGTGTCAGAAAGCAGGGATG GAGTTCCATGAAGAACTTCATAATTTGGGGGCAAAAGAAGGCTTGAAGGGAAGAAAACTC AACAAAGCAACTGAGAGCTTTGCTTGGAACATTACAGTATTGAAGGGCCAAGGAGATCTG TTGAAGAATGCCAAGAATGAAGCTATAGAAAACATGAAGCAGATCCAGCTGGCATGCCTG TCCTGTGGACTGAGTAAAGCCCCCAGCAGCAGTGCTGAGGCCAAGAGCAAGCGCAGCCTG GAAGCCATAGAGGAGAAGGAAAGTAGTGAGGAGAATGGGAAGCTGTGA
- Chromosome Location
- 2
- Locus
- 2q33
- External Identifiers
Resource Link UniProtKB ID Q15111 UniProtKB Entry Name PLCL1_HUMAN GenBank Protein ID 780122 GenBank Gene ID D42108 GenAtlas ID PLCL1 HGNC ID HGNC:9063 - General References
- Kohno T, Otsuka T, Takano H, Yamamoto T, Hamaguchi M, Terada M, Yokota J: Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma. Hum Mol Genet. 1995 Apr;4(4):667-74. [Article]
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- Yoshimura K, Takeuchi H, Sato O, Hidaka K, Doira N, Terunuma M, Harada K, Ogawa Y, Ito Y, Kanematsu T, Hirata M: Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha. J Biol Chem. 2001 May 25;276(21):17908-13. Epub 2001 Mar 2. [Article]
- Kanematsu T, Jang IS, Yamaguchi T, Nagahama H, Yoshimura K, Hidaka K, Matsuda M, Takeuchi H, Misumi Y, Nakayama K, Yamamoto T, Akaike N, Hirata M, Nakayama K: Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J. 2002 Mar 1;21(5):1004-11. [Article]
- Kanematsu T, Takeuchi H, Terunuma M, Hirata M: PRIP, a novel Ins(1,4,5)P3 binding protein, functional significance in Ca2+ signaling and extension to neuroscience and beyond. Mol Cells. 2005 Dec 31;20(3):305-14. [Article]
- Yanagihori S, Terunuma M, Koyano K, Kanematsu T, Ho Ryu S, Hirata M: Protein phosphatase regulation by PRIP, a PLC-related catalytically inactive protein--implications in the phospho-modulation of the GABAA receptor. Adv Enzyme Regul. 2006;46:203-22. Epub 2006 Jul 18. [Article]
- Murakami A, Matsuda M, Nakasima A, Hirata M: Characterization of the human PRIP-1 gene structure and transcriptional regulation. Gene. 2006 Nov 1;382:129-39. Epub 2006 Jul 20. [Article]
- Kanematsu T, Yasunaga A, Mizoguchi Y, Kuratani A, Kittler JT, Jovanovic JN, Takenaka K, Nakayama KI, Fukami K, Takenawa T, Moss SJ, Nabekura J, Hirata M: Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. J Biol Chem. 2006 Aug 4;281(31):22180-9. Epub 2006 Jun 5. [Article]
- Kanematsu T, Fujii M, Mizokami A, Kittler JT, Nabekura J, Moss SJ, Hirata M: Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex. J Neurochem. 2007 May;101(4):898-905. Epub 2007 Jan 24. [Article]