Potassium voltage-gated channel subfamily H member 2
Details
- Name
- Potassium voltage-gated channel subfamily H member 2
- Synonyms
- Eag homolog
- Eag-related protein 1
- ERG
- ERG-1
- ERG1
- Ether-a-go-go-related gene potassium channel 1
- Ether-a-go-go-related protein 1
- H-ERG
- HERG
- hERG-1
- hERG1
- Voltage-gated potassium channel subunit Kv11.1
- Gene Name
- KCNH2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000180|Potassium voltage-gated channel subfamily H member 2 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG AVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSV RSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSP PRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPP RHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIA PKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIY TAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANE EVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLD RYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSS GLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVS AIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGF PECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALY FISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLE VLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTE QPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSS PRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTP SLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSA VTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPG QLGALTSQPLHRHGSDPGS
- Number of residues
- 1159
- Molecular Weight
- 126653.52
- Theoretical pI
- 7.97
- GO Classification
- FunctionsC3HC4-type RING finger domain binding / delayed rectifier potassium channel activity / identical protein binding / inward rectifier potassium channel activity / phosphorelay sensor kinase activity / protein homodimerization activity / scaffold protein binding / ubiquitin protein ligase binding / voltage-gated potassium channel activity / voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationProcessescardiac muscle contraction / cellular response to drug / membrane depolarization during action potential / membrane repolarization during action potential / membrane repolarization during cardiac muscle cell action potential / negative regulation of potassium ion export / negative regulation of potassium ion transmembrane transport / positive regulation of potassium ion transmembrane transport / potassium ion export / potassium ion export across plasma membrane / potassium ion homeostasis / potassium ion transmembrane transport / regulation of heart rate by cardiac conduction / regulation of heart rate by hormone / regulation of membrane potential / regulation of membrane repolarization / regulation of potassium ion transmembrane transport / regulation of ventricular cardiac muscle cell membrane repolarization / synaptic transmission / ventricular cardiac muscle cell action potentialComponentscell surface / nuclear envelope / perinuclear region of cytoplasm / plasma membrane / voltage-gated potassium channel complex
- General Function
- Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
- Specific Function
- Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
- Pfam Domain Function
- Transmembrane Regions
- 404-424 451-471 496-516 521-541 548-568 639-659
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0021259|Potassium voltage-gated channel subfamily H member 2 (KCNH2) ATGCCGGTGCGGAGGGGCCACGTCGCGCCGCAGAACACCTTCCTGGACACCATCATCCGC AAGTTTGAGGGCCAGAGCCGTAAGTTCATCATCGCCAACGCTCGGGTGGAGAACTGCGCC GTCATCTACTGCAACGACGGCTTCTGCGAGCTGTGCGGCTACTCGCGGGCCGAGGTGATG CAGCGACCCTGCACCTGCGACTTCCTGCACGGGCCGCGCACGCAGCGCCGCGCTGCCGCG CAGATCGCGCAGGCACTGCTGGGCGCCGAGGAGCGCAAAGTGGAAATCGCCTTCTACCGG AAAGATGGGAGCTGCTTCCTATGTCTGGTGGATGTGGTGCCCGTGAAGAACGAGGATGGG GCTGTCATCATGTTCATCCTCAATTTCGAGGTGGTGATGGAGAAGGACATGGTGGGGTCC CCGGCTCATGACACCAACCACCGGGGCCCCCCCACCAGCTGGCTGGCCCCAGGCCGCGCC AAGACCTTCCGCCTGAAGCTGCCCGCGCTGCTGGCGCTGACGGCCCGGGAGTCGTCGGTG CGGTCGGGCGGCGCGGGCGGCGCGGGCGCCCCGGGGGCCGTGGTGGTGGACGTGGACCTG ACGCCCGCGGCACCCAGCAGCGAGTCGCTGGCCCTGGACGAAGTGACAGCCATGGACAAC CACGTGGCAGGGCTCGGGCCCGCGGAGGAGCGGCGTGCGCTGGTGGGTCCCGGCTCTCCG CCCCGCAGCGCGCCCGGCCAGCTCCCATCGCCCCGGGCGCACAGCCTCAACCCCGACGCC TCGGGCTCCAGCTGCAGCCTGGCCCGGACGCGCTCCCGAGAAAGCTGCGCCAGCGTGCGC CGCGCCTCGTCGGCCGACGACATCGAGGCCATGCGCGCCGGGGTGCTGCCCCCGCCACCG CGCCACGCCAGCACCGGGGCCATGCACCCACTGCGCAGCGGCTTGCTCAACTCCACCTCG GACTCCGACCTCGTGCGCTACCGCACCATTAGCAAGATTCCCCAAATCACCCTCAACTTT GTGGACCTCAAGGGCGACCCCTTCTTGGCTTCGCCCACCAGTGACCGTGAGATCATAGCA CCTAAGATAAAGGAGCGAACCCACAATGTCACTGAGAAGGTCACCCAGGTCCTGTCCCTG GGCGCCGACGTGCTGCCTGAGTACAAGCTGCAGGCACCGCGCATCCACCGCTGGACCATC CTGCATTACAGCCCCTTCAAGGCCGTGTGGGACTGGCTCATCCTGCTGCTGGTCATCTAC ACGGCTGTCTTCACACCCTACTCGGCTGCCTTCCTGCTGAAGGAGACGGAAGAAGGCCCG CCTGCTACCGAGTGTGGCTACGCCTGCCAGCCGCTGGCTGTGGTGGACCTCATCGTGGAC ATCATGTTCATTGTGGACATCCTCATCAACTTCCGCACCACCTACGTCAATGCCAACGAG GAGGTGGTCAGCCACCCCGGCCGCATCGCCGTCCACTACTTCAAGGGCTGGTTCCTCATC GACATGGTGGCCGCCATCCCCTTCGACCTGCTCATCTTCGGCTCTGGCTCTGAGGAGCTG ATCGGGCTGCTGAAGACTGCGCGGCTGCTGCGGCTGGTGCGCGTGGCGCGGAAGCTGGAT CGCTACTCAGAGTACGGCGCGGCCGTGCTGTTCTTGCTCATGTGCACCTTTGCGCTCATC GCGCACTGGCTAGCCTGCATCTGGTACGCCATCGGCAACATGGAGCAGCCACACATGGAC TCACGCATCGGCTGGCTGCACAACCTGGGCGACCAGATAGGCAAACCCTACAACAGCAGC GGCCTGGGCGGCCCCTCCATCAAGGACAAGTATGTGACGGCGCTCTACTTCACCTTCAGC AGCCTCACCAGTGTGGGCTTCGGCAACGTCTCTCCCAACACCAACTCAGAGAAGATCTTC TCCATCTGCGTCATGCTCATTGGCTCCCTCATGTATGCTAGCATCTTCGGCAACGTGTCG GCCATCATCCAGCGGCTGTACTCGGGCACAGCCCGCTACCACACACAGATGCTGCGGGTG CGGGAGTTCATCCGCTTCCACCAGATCCCCAATCCCCTGCGCCAGCGCCTCGAGGAGTAC TTCCAGCACGCCTGGTCCTACACCAACGGCATCGACATGAACGCGGTGCTGAAGGGCTTC CCTGAGTGCCTGCAGGCTGACATCTGCCTGCACCTGAACCGCTCACTGCTGCAGCACTGC AAACCCTTCCGAGGGGCCACCAAGGGCTGCCTTCGGGCCCTGGCCATGAAGTTCAAGACC ACACATGCACCGCCAGGGGACACACTGGTGCATGCTGGGGACCTGCTCACCGCCCTGTAC TTCATCTCCCGGGGCTCCATCGAGATCCTGCGGGGCGACGTCGTCGTGGCCATCCTGGGG AAGAATGACATCTTTGGGGAGCCTCTGAACCTGTATGCAAGGCCTGGCAAGTCGAACGGG GATGTGCGGGCCCTCACCTACTGTGACCTACACAAGATCCATCGGGACGACCTGCTGGAG GTGCTGGACATGTACCCTGAGTTCTCCGACCACTTCTGGTCCAGCCTGGAGATCACCTTC AACCTGCGAGATACCAACATGATCCCGGGCTCCCCCGGCAGTACGGAGTTAGAGGGTGGC TTCAGTCGGCAACGCAAGCGCAAGTTGTCCTTCCGCAGGCGCACGGACAAGGACACGGAG CAGCCAGGGGAGGTGTCGGCCTTGGGGCCGGGCCGGGCGGGGGCAGGGCCGAGTAGCCGG GGCCGGCCGGGGGGGCCGTGGGGGGAGAGCCCGTCCAGTGGCCCCTCCAGCCCTGAGAGC AGTGAGGATGAGGGCCCAGGCCGCAGCTCCAGCCCCCTCCGCCTGGTGCCCTTCTCCAGC CCCAGGCCCCCCGGAGAGCCGCCGGGTGGGGAGCCCCTGATGGAGGACTGCGAGAAGAGC AGCGACACTTGCAACCCCCTGTCAGGCGCCTTCTCAGGAGTGTCCAACATTTTCAGCTTC TGGGGGGACAGTCGGGGCCGCCAGTACCAGGAGCTCCCTCGATGCCCCGCCCCCACCCCC AGCCTCCTCAACATCCCCCTCTCCAGCCCGGGTCGGCGGCCCCGGGGCGACGTGGAGAGC AGGCTGGATGCCCTCCAGCGCCAGCTCAACAGGCTGGAGACCCGGCTGAGTGCAGACATG GCCACTGTCCTGCAGCTGCTACAGAGGCAGATGACGCTGGTCCCGCCCGCCTACAGTGCT GTGACCACCCCGGGGCCTGGCCCCACTTCCACATCCCCGCTGTTGCCCGTCAGCCCCCTC CCCACCCTCACCTTGGACTCGCTTTCTCAGGTTTCCCAGTTCATGGCGTGTGAGGAGCTG CCCCCGGGGGCCCCAGAGCTTCCCCAAGAAGGCCCCACACGACGCCTCTCCCTACCGGGC CAGCTGGGGGCCCTCACCTCCCAGCCCCTGCACAGACACGGCTCGGACCCGGGCAGTTAG
- Chromosome Location
- 7
- Locus
- 7q35-q36
- External Identifiers
Resource Link UniProtKB ID Q12809 UniProtKB Entry Name KCNH2_HUMAN GenBank Protein ID 487738 GenBank Gene ID U04270 GenAtlas ID KCNH2 HGNC ID HGNC:6251 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00308 Ibutilide approved yes inhibitor Details DB01182 Propafenone approved yes inhibitor Details DB00204 Dofetilide approved, investigational yes inhibitor Details DB00276 Amsacrine approved, investigational unknown inhibitor Details DB00489 Sotalol approved yes inhibitor Details DB00604 Cisapride approved, investigational, withdrawn unknown inhibitor Details DB00637 Astemizole approved, withdrawn unknown inhibitor Details DB00908 Quinidine approved, investigational unknown inhibitor Details DB01100 Pimozide approved yes inhibitor Details DB01136 Carvedilol approved, investigational unknown inhibitor Details DB01218 Halofantrine approved yes inhibitor Details DB00342 Terfenadine approved, withdrawn unknown inhibitor Details DB00661 Verapamil approved unknown inhibitor Details DB04855 Dronedarone approved yes inhibitor Details DB04957 Azimilide investigational unknown Details DB06144 Sertindole approved, investigational, withdrawn unknown inhibitor Details DB01162 Terazosin approved unknown inhibitor Details DB00457 Prazosin approved unknown inhibitor Details DB00679 Thioridazine approved, withdrawn unknown inhibitor Details DB00477 Chlorpromazine approved, investigational, vet_approved unknown inhibitor Details DB00458 Imipramine approved unknown inhibitor Details DB01142 Doxepin approved, investigational unknown inhibitor Details DB00537 Ciprofloxacin approved, investigational unknown Details DB01211 Clarithromycin approved unknown Details DB00199 Erythromycin approved, investigational, vet_approved no inhibitor Details DB06217 Vernakalant approved, investigational unknown blocker Details DB06457 Tecastemizole investigational unknown Details DB00455 Loratadine approved, investigational unknown antagonist Details DB01244 Bepridil approved, withdrawn unknown inhibitor Details DB00280 Disopyramide approved unknown inhibitor Details DB01195 Flecainide approved, withdrawn unknown inhibitor Details DB00472 Fluoxetine approved, vet_approved unknown inhibitor Details DB01026 Ketoconazole approved, investigational unknown inhibitor Details DB01035 Procainamide approved unknown inhibitor Details DB00675 Tamoxifen approved unknown inhibitor Details DB01074 Perhexiline approved, investigational unknown Details DB11386 Chlorobutanol approved, investigational, vet_approved unknown Details DB00176 Fluvoxamine approved, investigational unknown Details DB01149 Nefazodone approved, withdrawn unknown antagonist Details DB12364 Betrixaban approved, investigational unknown inhibitor Details DB11642 Pitolisant approved, investigational no blocker Details DB11633 Isavuconazole approved, investigational no inhibitor Details DB11090 Potassium nitrate approved unknown agonist Details DB11186 Pentoxyverine approved, investigational, withdrawn unknown inhibitor Details DB00252 Phenytoin approved, vet_approved yes inhibitor Details DB00557 Hydroxyzine approved unknown inhibitor Details DB00836 Loperamide approved no blocker Details DB01118 Amiodarone approved, investigational yes inhibitor Details DB00590 Doxazosin approved unknown inhibitor Details DB00321 Amitriptyline approved unknown blocker Details DB06207 Silodosin approved unknown blocker Details DB03701 Vanoxerine investigational unknown blocker Details DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details DB01069 Promethazine approved, investigational unknown inducer Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details