Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Details
- Name
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- Synonyms
- 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta
- 2.7.1.149
- Diphosphoinositide kinase 2-beta
- Phosphatidylinositol 5-phosphate 4-kinase type II beta
- PI(5)P 4-kinase type II beta
- PIP4KII-beta
- PIP5K2B
- PtdIns(5)P-4-kinase isoform 2-beta
- Gene Name
- PIP4K2B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051912|Phosphatidylinositol 5-phosphate 4-kinase type-2 beta MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNV PVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNS VTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLL PQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKD NDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEE RAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKK EVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
- Number of residues
- 416
- Molecular Weight
- 47377.625
- Theoretical pI
- Not Available
- GO Classification
- Functions1-phosphatidylinositol-3-phosphate 4-kinase activity / 1-phosphatidylinositol-4-phosphate 5-kinase activity / 1-phosphatidylinositol-5-phosphate 4-kinase activity / ATP binding / protein homodimerization activity / signal transducer activity, downstream of receptorProcessescell surface receptor signaling pathway / phosphatidylinositol biosynthetic process / phospholipid metabolic process / positive regulation of autophagosome assembly / regulation of autophagy / regulation of phosphatidylinositol 3-kinase signalingComponentsautophagosome / cytosol / endoplasmic reticulum membrane / nucleoplasm / plasma membrane
- General Function
- Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.
- Specific Function
- 1-phosphatidylinositol-3-phosphate 4-kinase activity
- Pfam Domain Function
- PIP5K (PF01504)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0051913|Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B) ATGTCGTCCAACTGCACCAGCACCACGGCGGTGGCGGTGGCGCCGCTCAGCGCCAGCAAG ACCAAGACCAAGAAGAAGCATTTCGTGTGCCAGAAAGTGAAGCTATTCCGGGCCAGCGAG CCGATCCTCAGCGTCCTGATGTGGGGGGTGAACCACACGATCAATGAGCTGAGCAATGTT CCTGTTCCTGTCATGCTAATGCCAGATGACTTCAAAGCCTACAGCAAGATCAAGGTGGAC AATCATCTCTTCAATAAGGAGAACCTGCCCAGCCGCTTTAAGTTTAAGGAGTATTGCCCC ATGGTGTTCCGAAACCTTCGGGAGAGGTTTGGAATTGATGATCAGGATTACCAGAATTCA GTGACGCGCAGCGCCCCCATCAACAGTGACAGCCAGGGTCGGTGTGGCACGCGTTTCCTC ACCACCTACGACCGGCGCTTTGTCATCAAGACTGTGTCCAGCGAGGACGTGGCGGAGATG CACAACATCTTAAAGAAATACCACCAGTTTATAGTGGAGTGTCATGGCAACACGCTTTTG CCACAGTTCCTGGGCATGTACCGCCTGACCGTGGATGGTGTGGAAACCTACATGGTGGTT ACCAGGAACGTGTTCAGCCATCGGCTCACTGTGCATCGCAAGTATGACCTCAAGGGTTCT ACGGTTGCCAGAGAAGCGAGCGACAAGGAGAAGGCCAAGGACTTGCCAACATTCAAAGAC AATGACTTCCTCAATGAAGGGCAGAAGCTGCATGTGGGAGAGGAGAGTAAAAAGAACTTC CTGGAGAAACTGAAGCGGGACGTTGAGTTCTTGGCACAGCTGAAGATCATGGACTACAGC CTGCTGGTGGGCATCCACGACGTGGACCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAG CGGGCAGAGGACGAGGAGTGTGAGAATGATGGGGTGGGTGGCAACCTACTCTGCTCCTAT GGCACACCTCCGGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTCTTTGGTCCTGGG GAATTCGACCCCTCTGTTGACGTCTATGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAG GAGGTGTATTTCATGGCCATCATTGATATCCTCACGCCATACGATACAAAGAAGAAAGCT GCACATGCTGCCAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCGACTGTGAACCCT GAGCAGTACTCCAAACGCTTCAACGAGTTTATGTCCAACATCCTGACGTAG
- Chromosome Location
- 17
- Locus
- 17q12
- External Identifiers
Resource Link UniProtKB ID P78356 UniProtKB Entry Name PI42B_HUMAN HGNC ID HGNC:8998 - General References
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