Histamine N-methyltransferase
Details
- Name
- Histamine N-methyltransferase
- Synonyms
- 2.1.1.8
- HMT
- Gene Name
- HNMT
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004783|Histamine N-methyltransferase MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIG GGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETS SEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWD KLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
- Number of residues
- 292
- Molecular Weight
- 33294.765
- Theoretical pI
- 4.98
- GO Classification
- Functionshistamine N-methyltransferase activityProcessesbrain development / cellular nitrogen compound metabolic process / histidine catabolic process / hyperosmotic response / methylation / positive regulation of protein targeting to mitochondrion / respiratory gaseous exchange / response to amine / response to cocaine / response to glucocorticoid / response to immobilization stress / response to interleukin-1 / response to tumor cell / small molecule metabolic processComponentscytoplasm / cytosol / extracellular exosome / neuron projection / nucleoplasm
- General Function
- Histamine n-methyltransferase activity
- Specific Function
- Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011743|Histamine N-methyltransferase (HNMT) ATGGCATCTTCCATGAGGAGCTTGTTTTCTGACCACGGGAAATATGTTGAATCTTTCCGG AGGTTTCTCAACCATTCCACGGAACACCAGTGCATGCAGGAATTCATGGACAAGAAGCTG CCAGGCATAATAGGAAGATACCAGAATTGCTGTTAA
- Chromosome Location
- 2
- Locus
- 2q22.1
- External Identifiers
Resource Link UniProtKB ID P50135 UniProtKB Entry Name HNMT_HUMAN GenBank Gene ID D16224 GenAtlas ID HNMT HGNC ID HGNC:5028 - General References
- Yamauchi K, Sekizawa K, Suzuki H, Nakazawa H, Ohkawara Y, Katayose D, Ohtsu H, Tamura G, Shibahara S, Takemura M, et al.: Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. Am J Physiol. 1994 Sep;267(3 Pt 1):L342-9. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00613 Amodiaquine approved, investigational unknown inhibitor Details DB01752 S-adenosyl-L-homocysteine experimental unknown Details DB04655 Metoprine experimental unknown Details DB05381 Histamine approved, investigational unknown substrate Details DB01103 Quinacrine investigational unknown inhibitor Details DB01752 S-adenosyl-L-homocysteine experimental unknown inhibitorbinder Details DB07106 SKF-91488 experimental unknown inhibitor Details DB13875 Harmaline experimental unknown inhibitor Details