Phosphatidylserine synthase 1
Details
- Name
- Phosphatidylserine synthase 1
- Synonyms
- 2.7.8.29
- KIAA0024
- PSS-1
- PSSA
- Serine-exchange enzyme I
- Gene Name
- PTDSS1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002187|Phosphatidylserine synthase 1 MASCVGSRTLSKDDVNYKMHFRMINEQQVEDITIDFFYRPHTITLLSFTIVSLMYFAFTR DDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLF LNFEQVKSLMYWLDPNLRYATREADVMEYAVNCHVITWERIISHFDIFAFGHFWGWAMKA LLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFL EMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGVYLFMIIWQLT ELNTFFLKHIFVFQASHPLSWGRILFIGGITAPTVRQYYAYLTDTQCKRVGTQCWVFGVI GFLEAIVCIKFGQDLFSKTQILYVVLWLLCVAFTTFLCLYGMIWYAEHYGHREKTYSECE DGTYSPEISWHHRKGTKGSEDSPPKHAGNNESHSSRRRNRHSKSKVTNGVGKK
- Number of residues
- 473
- Molecular Weight
- 55527.18
- Theoretical pI
- 8.52
- GO Classification
- Functionstransferase activityProcessesglycerophospholipid biosynthetic process / phosphatidylserine biosynthetic process / phospholipid metabolic process / small molecule metabolic processComponentsendoplasmic reticulum membrane / integral component of membrane / membrane
- General Function
- Transferase activity
- Specific Function
- Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine.
- Pfam Domain Function
- PSS (PF03034)
- Transmembrane Regions
- 36-56 73-93 103-123 187-207 217-237 287-307 320-342 356-376 384-404
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0010770|Phosphatidylserine synthase 1 (PTDSS1) ATGGAGTATGCTGTGAACTGCCATGTGATCACCTGGGAGAGGATTATCAGCCACTTTGAT ATTTTTGCATTTGGACATTTCTGGGGCTGGGCCATGAAGGCCTTGCTGATCCGTAGTTAC GGTCTCTGCTGGACAATCAGTATTACCTGGGAGCTGACTGAGCTCTTCTTCATGCATCTC CTCCCCAATTTTGCCGAGTGCTGGTGGGATCAAGTCATTCTGGACATCCTGTTGTGCAAT GGCGGTGGCATTTGGCTGGGCATGGTCGTTTGCCGGTTTTTAGAGATGAGGACTTACCAC TGGGCAAGCTTCAAGGACATTCATACCACCACCGGGAAGATCAAGAGAGCTGTTCTGCAG TTCACTCCTGCTAGCTGGACCTATGTTCGATGGTTTGACCCCAAATCTTCTTTTCAGAGA GTAGCTGGAGTGTACCTTTTCATGATCATCTGGCAGCTGACTGAGTTGAATACCTTCTTC TTGAAGCATATCTTTGTGTTCCAAGCCAGTCATCCATTAAGTTGGGGTAGAATTCTCTTT ATTGGTGGCATCACAGCTCCCACAGTGAGACAGTACTACGCTTACCTCACCGACACACAG TGCAAGCGCGTAGGAACACAATGCTGGGTGTTTGGGGTCATTGGTTTCCTGGAGGCCATT GTTTGCATAAAATTTGGACAAGATCTCTTCTCTAAGACCCAAATACTCTATGTTGTGCTT TGGCTTCTTTGCGTGGCTTTCACCACTTTCCTCTGTCTGTACGGCATGATTTGGTATGCA GAACACTATGGTCACCGAGAAAAGACCTACTCGGAGTGTGAAGATGGCACCTACAGTCCA GAGATCTCCTGGCATCACAGGAAAGGGACAAAAGGTTCTGAAGACAGCCCACCCAAGCAT GCAGGCAACAACGAAAGCCATTCTTCCAGGAGAAGGAATCGGCATTCCAAGTCAAAAGTC ACCAATGGCGTTGGAAAGAAATGA
- Chromosome Location
- 8
- Locus
- 8q22
- External Identifiers
Resource Link UniProtKB ID P48651 UniProtKB Entry Name PTSS1_HUMAN GenBank Protein ID 603802 GenBank Gene ID D14694 GenAtlas ID PTDSS1 HGNC ID HGNC:9587 - General References
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