Cytochrome P450 2C18
Details
- Name
- Cytochrome P450 2C18
- Synonyms
- 1.14.14.1
- CYPIIC18
- Cytochrome P450-6b/29c
- Gene Name
- CYP2C18
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006947|Cytochrome P450 2C18 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP PLYQLCFIPV
- Number of residues
- 490
- Molecular Weight
- 55710.075
- Theoretical pI
- 7.22
- GO Classification
- Functionsarachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activityProcessesepoxygenase P450 pathway / exogenous drug catabolic process / oxidation-reduction process / small molecule metabolic process / xenobiotic metabolic processComponentscytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0012511|Cytochrome P450 2C18 (CYP2C18) ATGGATCCAGCTGTGGCTCTGGTGCTCTGTCTCTCCTGTTTGTTTCTCCTTTCACTCTGG AGGCAGAGCTCTGGAAGAGGGAGGCTCCCGTCTGGCCCCACTCCTCTCCCGATTATTGGA AATATCCTGCAGTTAGATGTTAAGGACATGAGCAAATCCTTAACCAATTTCTCAAAAGTC TATGGCCCTGTGTTCACTGTGTATTTTGGCCTGAAGCCCATTGTGGTGTTGCATGGATAT GAAGCAGTGAAGGAGGCCCTGATTGATCATGGAGAGGAGTTTTCTGGAAGAGGAAGTTTT CCAGTGGCTGAAAAAGTTAACAAAGGACTTGGAATCCTTTTCAGCAATGGAAAGAGATGG AAGGAGATCCGGCGTTTCTGCCTCATGACTCTGCGGAATTTTGGGATGGGGAAGAGGAGC ATCGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAT GCCTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCT GTTATTTTCCATGATCGATTTGATTATAAAGATCAGAGGTTTCTTAACTTGATGGAAAAA TTCAATGAAAACCTCAGGATTCTGAGCTCTCCATGGATCCAGGTCTGCAATAATTTCCCT GCTCTCATCGATTATCTCCCAGGAAGTCATAATAAAATAGCTGAAAATTTTGCTTACATT AAAAGTTATGTATTGGAGAGAATAAAAGAACATCAAGAATCCCTGGACATGAACAGTGCT CGGGACTTTATTGATTGTTTCCTGATCAAAATGGAACAGGAAAAGCACAATCAACAGTCT GAATTTACTGTTGAAAGCTTGATAGCCACTGTAACTGATATGTTTGGGGCTGGAACAGAG ACAACGAGCACCACTCTGAGATATGGACTCCTGCTCCTGCTGAAGTACCCAGAGGTCACA GCTAAAGTCCAGGAAGAGATTGAATGTGTAGTTGGCAGAAACCGGAGCCCCTGTATGCAG GACAGGAGTCACATGCCCTACACAGATGCTGTGGTGCACGAGATCCAGAGATACATTGAC CTCCTCCCCACCAACCTGCCCCATGCAGTGACCTGTGATGTTAAATTCAAAAACTACCTC ATCCCCAAGGGCACGACCATAATAACATCCCTGACTTCTGTGCTGCACAATGACAAAGAA TTCCCCAACCCAGAGATGTTTGACCCTGGCCACTTTCTGGATAAGAGTGGCAACTTTAAG AAAAGTGACTACTTCATGCCTTTCTCAGCAGGAAAACGGATGTGTATGGGAGAGGGCCTG GCCCGCATGGAGCTGTTTTTATTCCTGACCACCATTTTGCAGAACTTTAACCTGAAATCT CAGGTTGACCCAAAGGATATTGACATCACCCCCATTGCCAATGCATTTGGTCGTGTGCCA CCCTTGTACCAGCTCTGCTTCATTCCTGTCTGA
- Chromosome Location
- 10
- Locus
- 10q24
- External Identifiers
Resource Link UniProtKB ID P33260 UniProtKB Entry Name CP2CI_HUMAN GenBank Gene ID M61853 HGNC ID HGNC:2620 - General References
- Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA: Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. Biochemistry. 1991 Apr 2;30(13):3247-55. [Article]
- Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA: Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily. Biochemistry. 1993 Feb 9;32(5):1390. [Article]
- de Morais SM, Schweikl H, Blaisdell J, Goldstein JA: Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. Biochem Biophys Res Commun. 1993 Jul 15;194(1):194-201. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01181 Ifosfamide approved unknown substrate Details DB01424 Aminophenazone approved, withdrawn unknown substrate Details DB00682 Warfarin approved unknown substrate Details DB07670 N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide experimental unknown Details DB00921 Buprenorphine approved, illicit, investigational, vet_approved unknown substrate Details DB00349 Clobazam approved, illicit no substrate Details DB01559 Clotiazepam approved, illicit unknown substrate Details DB00531 Cyclophosphamide approved, investigational unknown substrate Details DB00250 Dapsone approved, investigational unknown substrate Details DB00829 Diazepam approved, illicit, investigational, vet_approved unknown substrate Details DB00586 Diclofenac approved, vet_approved unknown substrate Details DB00458 Imipramine approved unknown substrate Details DB00448 Lansoprazole approved, investigational unknown substrate Details DB00333 Methadone approved unknown substrate Details DB00338 Omeprazole approved, investigational, vet_approved unknown substrate Details DB00850 Perphenazine approved unknown substrate Details DB01435 Antipyrine approved, investigational unknown substrate Details DB00818 Propofol approved, investigational, vet_approved unknown substrate Details DB01124 Tolbutamide approved, investigational unknown substrate Details DB00755 Tretinoin approved, investigational, nutraceutical unknown substrate Details DB01174 Phenobarbital approved, investigational unknown substrate Details DB09166 Etizolam experimental unknown substrate Details DB08496 (R)-warfarin experimental unknown substrate Details DB14055 (S)-Warfarin experimental, investigational unknown substrate Details DB11757 Istradefylline approved, investigational unknown substrate Details DB00661 Verapamil approved unknown substrate Details DB00252 Phenytoin approved, vet_approved no substrate Details DB00986 Glycopyrronium approved, investigational, vet_approved unknown substrate Details DB01183 Naloxone approved, vet_approved unknown substrate Details DB15059 Aprocitentan approved, investigational no inhibitor Details