B2 bradykinin receptor
Details
- Name
- B2 bradykinin receptor
- Synonyms
- B2R
- BKR2
- Gene Name
- BDKRB2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006785|B2 bradykinin receptor MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
- Number of residues
- 391
- Molecular Weight
- 44460.15
- Theoretical pI
- 8.2
- GO Classification
- Functionsbradykinin receptor activity / phosphatidylinositol phospholipase C activity / protease binding / protein heterodimerization activity / type 1 angiotensin receptor bindingProcessesacute inflammatory response to antigenic stimulus / arachidonic acid secretion / blood circulation / cell surface receptor signaling pathway / cellular response to hypoxia / G-protein coupled receptor signaling pathway / inflammatory response / maintenance of blood-brain barrier / negative regulation of blood pressure / negative regulation of cell proliferation / negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator / negative regulation of peptidyl-serine phosphorylation / positive regulation of cytosolic calcium ion concentration / regulation of vascular permeability / regulation of vasoconstriction / response to drug / response to salt stress / smooth muscle contraction / transmembrane receptor protein tyrosine kinase signaling pathway / vasoconstriction / vasodilationComponentscytosol / endosome / integral component of plasma membrane / plasma membrane
- General Function
- Type 1 angiotensin receptor binding
- Specific Function
- Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 61-84 94-118 132-153 176-198 222-248 268-292 312-335
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017128|B2 bradykinin receptor (BDKRB2) ATGTTCTCTCCCTGGAAGATATCAATGTTTCTGTCTGTTCGTGAGGACTCCGTGCCCACC ACGGCCTCTTTCAGCGCCGACATGCTCAATGTCACCTTGCAAGGGCCCACTCTTAACGGG ACCTTTGCCCAGAGCAAATGCCCCCAAGTGGAGTGGCTGGGCTGGCTCAACACCATCCAG CCCCCCTTCCTCTGGGTGCTGTTCGTGCTGGCCACCCTAGAGAACATCTTTGTCCTCAGC GTCTTCTGCCTGCACAAGAGCAGCTGCACGGTGGCAGAGATCTACCTGGGGAACCTGGCC GCAGCAGACCTGATCCTGGCCTGCGGGCTGCCCTTCTGGGCCATCACCATCTCCAACAAC TTCGACTGGCTCTTTGGGGAGACGCTCTGCCGCGTGGTGAATGCCATTATCTCCATGAAC CTGTACAGCAGCATCTGTTTCCTGATGCTGGTGAGCATCGACCGCTACCTGGCCCTGGTG AAAACCATGTCCATGGGCCGGATGCGCGGCGTGCGCTGGGCCAAGCTCTACAGCTTGGTG ATCTGGGGGTGTACGCTGCTCCTGAGCTCACCCATGCTGGTGTTCCGGACCATGAAGGAG TACAGCGATGAGGGCCACAACGTCACCGCTTGTGTCATCAGCTACCCATCCCTCATCTGG GAAGTGTTCACCAACATGCTCCTGAATGTCGTGGGCTTCCTGCTGCCCCTGAGTGTCATC ACCTTCTGCACGATGCAGATCATGCAGGTGCTGCGGAACAACGAGATGCAGAAGTTCAAG GAGATCCAGACAGAGAGGAGGGCCACGGTGCTAGTCCTGGTTGTGCTGCTGCTATTCATC ATCTGCTGGCTGCCCTTCCAGATCAGCACCTTCCTGGATACGCTGCATCGCCTCGGCATC CTCTCCAGCTGCCAGGACGAGCGCATCATCGATGTAATCACACAGATCGCCTCCTTCATG GCCTACAGCAACAGCTGCCTCAACCCACTGGTGTACGTGATCGTGGGCAAGCGCTTCCGA AAGAAGTCTTGGGAGGTGTACCAGGGAGTGTGCCAGAAAGGGGGCTGCAGGTCAGAACCC ATTCAGATGGAGAACTCCATGGGCACACTGCGGACCTCCATCTCCGTGGAACGCCAGATT CACAAACTGCAGGACTGGGCAGGGAGCAGACAGTGA
- Chromosome Location
- 14
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P30411 UniProtKB Entry Name BKRB2_HUMAN GenBank Gene ID BC074895 GenAtlas ID BDKRB2 HGNC ID HGNC:1030 - General References
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- Powell SJ, Slynn G, Thomas C, Hopkins B, Briggs I, Graham A: Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. Genomics. 1993 Feb;15(2):435-8. [Article]
- McIntyre P, Phillips E, Skidmore E, Brown M, Webb M: Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. Mol Pharmacol. 1993 Aug;44(2):346-55. [Article]
- Eggerickx D, Raspe E, Bertrand D, Vassart G, Parmentier M: Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. Biochem Biophys Res Commun. 1992 Sep 30;187(3):1306-13. [Article]
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