D(4) dopamine receptor
Details
- Name
- D(4) dopamine receptor
- Synonyms
- D(2C) dopamine receptor
- Dopamine D4 receptor
- Gene Name
- DRD4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000775|D(4) dopamine receptor MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPG LPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAP PDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALC PACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
- Number of residues
- 467
- Molecular Weight
- 48359.86
- Theoretical pI
- 8.37
- GO Classification
- Functionsdopamine binding / dopamine neurotransmitter receptor activity / dopamine neurotransmitter receptor activity, coupled via Gi/Go / drug binding / G-protein coupled amine receptor activity / identical protein binding / potassium channel regulator activity / SH3 domain bindingProcessesactivation of MAPK activity / adenylate cyclase-inhibiting dopamine receptor signaling pathway / adult locomotory behavior / arachidonic acid secretion / behavioral fear response / behavioral response to cocaine / behavioral response to ethanol / cellular calcium ion homeostasis / circadian rhythm / dopamine metabolic process / dopamine receptor signaling pathway / fear response / inhibitory postsynaptic potential / negative regulation of adenylate cyclase activity / negative regulation of cAMP biosynthetic process / negative regulation of protein secretion / negative regulation of voltage-gated calcium channel activity / olfactory learning / photoperiodism / positive regulation of dopamine uptake involved in synaptic transmission / positive regulation of excitatory postsynaptic potential / positive regulation of kinase activity / positive regulation of penile erection / positive regulation of sodium / regulation of calcium-mediated signaling / regulation of circadian rhythm / regulation of dopamine metabolic process / regulation of neurotransmitter secretion / response to amphetamine / response to histamine / response to steroid hormone / retina development in camera-type eye / sensory perception of chemical stimulus / short-term memory / social behavior / synaptic transmission / synaptic transmission, dopaminergicComponentscell cortex / dendritic spine / integral component of plasma membrane / membrane / neuronal cell body / plasma membrane / terminal bouton / vesicle membrane
- General Function
- Sh3 domain binding
- Specific Function
- Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 38-60 71-93 110-131 152-175 192-213 395-417 427-449
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010271|D(4) dopamine receptor (DRD4) ATGGGGAACCGCAGCACCGCGGACGCGGACGGGCTGCTGGCTGGGCGCGGGCCGGCCGCG GGGGCATCTGCGGGGGCATCTGCGGGGCTGGCTGGGCAGGGCGCGGCGGCGCTGGTGGGG GGCGTGCTGCTCATCGGCGCGGTGCTCGCGGGGAACTCGCTCGTGTGCGTGAGCGTGGCC ACCGAGCGCGCCCTGCAGACGCCCACCAACTCCTTCATCGTGAGCCTGGCGGCCGCCGAC CTCCTCCTCGCTCTCCTGGTGCTGCCGCTCTTCGTCTACTCCGAGGTCCAGGGTGGCGCG TGGCTGCTGAGCCCCCGCCTGTGCGACGCCCTCATGGCCATGGACGTCATGCTGTGCACC GCCTCCATCTTCAACCTGTGCGCCATCAGCGTGGACAGGTTCGTGGCCGTGGCCGTGCCG CTGCGCTACAACCGGCAGGGTGGGAGCCGCCGGCAGCTGCTGCTCATCGGCGCCACGTGG CTGCTGTCCGCGGCGGTGGCGGCGCCCGTACTGTGCGGCCTCAACGACGTGCGCGGCCGC GACCCCGCCGTGTGCCGCCTGGAGGACCGCGACTACGTGGTCTACTCGTCCGTGTGCTCC TTCTTCCTACCCTGCCCGCTCATGCTGCTGCTCTACTGGGCCACGTTCCGCGGCCTGCAG CGCTGGGAGGTGGCACGTCGCGCCAAGCTGCACGGCCGCGCGCCCCGCCGACCCAGCGGC CCTGGCCCGCCTTCCCCCACGCCACCCGCGCCCCGCCTCCCCCAGGACCCCTGCGGCCCC GACTGTGCGCCCCCCGCGCCCGGCCTTCCCCGGGGTCCCTGCGGCCCCGACTGTGCGCCC GCCGCGCCCAGCCTCCCCCAGGACCCCTGCGGCCCCGACTGTGCGCCCCCCGCGCCCGGC CTCCCCCCGGACCCCTGCGGCTCCAACTGTGCTCCCCCCGACGCCGTCAGAGCCGCCGCG CTCCCACCCCAGACTCCACCGCAGACCCGCAGGAGGCGGCGTGCCAAGATCACCGGCCGG GAGCGCAAGGCCATGAGGGTCCTGCCGGTGGTGGTCGGGGCCTTCCTGCTGTGCTGGACG CCCTTCTTCGTGGTGCACATCACGCAGGCGCTGTGTCCTGCCTGCTCCGTGCCCCCGCGG CTGGTCAGCGCCGTCACCTGGCTGGGCTACGTCAACAGCGCCCTCAACCCCGTCATCTAC ACTGTCTTCAACGCCGAGTTCCGCAACGTCTTCCGCAAGGCCCTGCGTGCCTGCTGCTGA
- Chromosome Location
- 11
- Locus
- 11p15.5
- External Identifiers
Resource Link UniProtKB ID P21917 UniProtKB Entry Name DRD4_HUMAN GenBank Protein ID 291946 GenBank Gene ID L12398 GenAtlas ID DRD4 HGNC ID HGNC:3025 - General References
- Van Tol HH, Wu CM, Guan HC, Ohara K, Bunzow JR, Civelli O, Kennedy J, Seeman P, Niznik HB, Jovanovic V: Multiple dopamine D4 receptor variants in the human population. Nature. 1992 Jul 9;358(6382):149-52. [Article]
- Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O: Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature. 1991 Apr 18;350(6319):610-4. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
- Lichter JB, Barr CL, Kennedy JL, Van Tol HH, Kidd KK, Livak KJ: A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet. 1993 Jun;2(6):767-73. [Article]
- Asghari V, Schoots O, van Kats S, Ohara K, Jovanovic V, Guan HC, Bunzow JR, Petronis A, Van Tol HH: Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol. 1994 Aug;46(2):364-73. [Article]
- Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M: Modulation of postendocytic sorting of G protein-coupled receptors. Science. 2002 Jul 26;297(5581):615-20. [Article]
- Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K: BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. J Biol Chem. 2008 Apr 25;283(17):11083-96. doi: 10.1074/jbc.M708473200. Epub 2008 Feb 26. [Article]
- Woods AS: The dopamine D(4) receptor, the ultimate disordered protein. J Recept Signal Transduct Res. 2010 Oct;30(5):331-6. doi: 10.3109/10799893.2010.513842. [Article]
- Rondou P, Skieterska K, Packeu A, Lintermans B, Vanhoenacker P, Vauquelin G, Haegeman G, Van Craenenbroeck K: KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation. Cell Signal. 2010 Jun;22(6):900-13. doi: 10.1016/j.cellsig.2010.01.014. Epub 2010 Jan 25. [Article]
- Borroto-Escuela DO, Van Craenenbroeck K, Romero-Fernandez W, Guidolin D, Woods AS, Rivera A, Haegeman G, Agnati LF, Tarakanov AO, Fuxe K: Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions. Biochem Biophys Res Commun. 2011 Jan 28;404(4):928-34. doi: 10.1016/j.bbrc.2010.12.083. Epub 2010 Dec 22. [Article]
- Livingstone CD, Strange PG, Naylor LH: Molecular modelling of D2-like dopamine receptors. Biochem J. 1992 Oct 1;287 ( Pt 1):277-82. [Article]
- Seeman P, Ulpian C, Chouinard G, Van Tol HH, Dwosh H, Lieberman JA, Siminovitch K, Liu IS, Waye J, Voruganti P, et al.: Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: no association with schizophrenia. Am J Med Genet. 1994 Dec 15;54(4):384-90. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00363 Clozapine approved unknown antagonist Details DB00246 Ziprasidone approved unknown antagonist Details DB00334 Olanzapine approved, investigational unknown antagonist Details DB00714 Apomorphine approved, investigational yes agonist Details DB00413 Pramipexole approved, investigational yes agonist Details DB00268 Ropinirole approved, investigational unknown agonist Details DB04908 Flibanserin approved, investigational yes antagonistagonist Details DB12061 Pardoprunox investigational unknown Details DB06216 Asenapine approved unknown antagonist Details DB06477 Sumanirole investigational unknown Details DB01186 Pergolide approved, investigational, vet_approved, withdrawn yes agonist Details DB01200 Bromocriptine approved, investigational, withdrawn unknown antagonist Details DB00589 Lisuride approved, investigational yes agonist Details DB00248 Cabergoline approved unknown agonist Details DB05271 Rotigotine approved yes agonist Details DB01267 Paliperidone approved yes antagonist Details DB01238 Aripiprazole approved, investigational unknown antagonistpartial agonist Details DB01224 Quetiapine approved unknown ligand Details DB01403 Methotrimeprazine approved, investigational unknown antagonist Details DB00409 Remoxipride approved, withdrawn unknown antagonist Details DB00988 Dopamine approved yes agonist Details DB01235 Levodopa approved yes agonist Details DB04946 Iloperidone approved unknown antagonist Details DB00477 Chlorpromazine approved, investigational, vet_approved unknown binder Details DB00408 Loxapine approved unknown binder Details DB00543 Amoxapine approved unknown antagonist Details DB08922 Perospirone experimental unknown antagonist Details DB09286 Pipamperone investigational unknown antagonist Details DB14185 Aripiprazole lauroxil approved, investigational unknown Details DB00490 Buspirone approved, investigational unknown antagonist Details DB00875 Flupentixol approved, investigational, withdrawn unknown antagonist Details DB00391 Sulpiride approved, investigational unknown antagonist Details DB00320 Dihydroergotamine approved, investigational unknown agonist Details DB13345 Dihydroergocristine approved, experimental yes antagonistagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11275 Epicriptine approved yes agonist Details DB08804 Nandrolone decanoate approved, illicit unknown modulator Details