Natriuretic peptides B
Details
- Name
- Natriuretic peptides B
- Synonyms
- Gamma-brain natriuretic peptide
- Gene Name
- NPPB
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001949|Natriuretic peptides B MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVE QTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRI SSSSGLGCKVLRRH
- Number of residues
- 134
- Molecular Weight
- 14725.825
- Theoretical pI
- 11.01
- GO Classification
- Functionsdiuretic hormone activity / hormone activity / receptor bindingProcessesbody fluid secretion / cell surface receptor signaling pathway / cGMP biosynthetic process / negative regulation of angiogenesis / negative regulation of cell growth / positive regulation of renal sodium excretion / positive regulation of urine volume / receptor guanylyl cyclase signaling pathway / regulation of blood pressure / regulation of blood vessel size / regulation of vascular permeability / regulation of vasodilationComponentsextracellular region / extracellular space / protein complex
- General Function
- Receptor binding
- Specific Function
- Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
- Pfam Domain Function
- ANP (PF00212)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0016272|Natriuretic peptides B (NPPB) ATGGATCCCCAGACAGCACCTTCCCGGGCGCTCCTGCTCCTGCTCTTCTTGCATCTGGCT TTCCTGGGAGGTCGTTCCCACCCGCTGGGCAGCCCCGGTTCAGCCTCGGACTTGGAAACG TCCGGGTTACAGGAGCAGCGCAACCATTTGCAGGGCAAACTGTCGGAGCTGCAGGTGGAG CAGACATCCCTGGAGCCCCTCCAGGAGAGCCCCCGTCCCACAGGTGTCTGGAAGTCCCGG GAGGTAGCCACCGAGGGCATCCGTGGGCACCGCAAAATGGTCCTCTACACCCTGCGGGCA CCACGAAGCCCCAAGATGGTGCAAGGGTCTGGCTGCTTTGGGAGGAAGATGGACCGGATC AGCTCCTCCAGTGGCCTGGGCTGCAAAGTGCTGAGGCGGCATTAA
- Chromosome Location
- 1
- Locus
- 1p36.2
- External Identifiers
Resource Link UniProtKB ID P16860 UniProtKB Entry Name ANFB_HUMAN GenBank Protein ID 179515 GenBank Gene ID M31776 GenAtlas ID NPPB HGNC ID HGNC:7940 - General References
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- Sudoh T, Maekawa K, Kojima M, Minamino N, Kangawa K, Matsuo H: Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide. Biochem Biophys Res Commun. 1989 Mar 31;159(3):1427-34. [Article]
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