Retinoic acid receptor gamma
Details
- Name
- Retinoic acid receptor gamma
- Synonyms
- NR1B3
- Nuclear receptor subfamily 1 group B member 3
- RAR-gamma
- Gene Name
- RARG
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000287|Retinoic acid receptor gamma MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
- Number of residues
- 454
- Molecular Weight
- 50341.405
- Theoretical pI
- 7.52
- GO Classification
- FunctionsDNA binding / retinoic acid receptor activity / retinoid X receptor binding / RNA polymerase II regulatory region sequence-specific DNA binding / steroid hormone receptor activity / transcription factor activity, sequence-specific DNA binding / zinc ion bindingProcessesanterior/posterior pattern specification / canonical Wnt signaling pathway / cellular response to retinoic acid / embryonic camera-type eye development / embryonic eye morphogenesis / embryonic hindlimb morphogenesis / face development / gene expression / glandular epithelial cell development / growth plate cartilage chondrocyte growth / Harderian gland development / multicellular organism growth / negative regulation of apoptotic process / negative regulation of cell proliferation / negative regulation of chondrocyte differentiation / negative regulation of transcription from RNA polymerase II promoter / neural tube closure / positive regulation of apoptotic process / positive regulation of cell proliferation / positive regulation of programmed cell death / positive regulation of transcription from RNA polymerase II promoter / prostate gland epithelium morphogenesis / regulation of cell size / regulation of myelination / regulation of myeloid cell differentiation / response to retinoic acid / retinal pigment epithelium development / retinoic acid receptor signaling pathway / trachea cartilage development / transcription initiation from RNA polymerase II promoterComponentsintegral component of membrane / nuclear chromatin / nucleoplasm / nucleus / transcription factor complex
- General Function
- Zinc ion binding
- Specific Function
- Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0020450|Retinoic acid receptor gamma (RARG) ATGGCCACCAATAAGGAGCGACTCTTTGCGGCTGGTGCCCTGGGGCCTGGATCTGGCTAC CCAGGGGCAGGTTTCCCCTTCGCCTTCCCAGGGGCACTCAGGGGGTCTCCGCCTTTCGAG ATGCTGAGCCCTAGCTTCCGGGGCCTGGGCCAGCCTGACCTCCCCAAGGAGATGGCCTCT CTGTCGGTGGAGACACAGAGCACCAGCTCAGAGGAGATGGTGCCCAGCTCGCCCTCGCCC CCTCCGCCTCCTCGGGTCTACAAGCCATGCTTCGTGTGCAATGACAAGTCCTCTGGCTAC CACTATGGGGTCAGCTCTTGTGAAGGCTGCAAGGGCTTCTTTCGCCGAAGCATCCAGAAG AACATGGTGTACACGTGTCACCGCGACAAAAACTGTATCATCAACAAGGTGACCAGGAAT CGCTGCCAGTACTGCCGGCTACAGAAGTGCTTCGAAGTGGGCATGTCCAAGGAAGCTGTG CGAAATGACCGGAACAAGAAGAAGAAAGAGGTGAAGGAAGAAGGGTCACCTGACAGCTAT GAGCTGAGCCCTCAGTTAGAAGAGCTCATCACCAAGGTCAGCAAAGCCCATCAGGAGACT TTCCCCTCGCTCTGCCAGCTGGGCAAGTATACCACGAACTCCAGTGCAGACCACCGCGTG CAGCTGGATCTGGGGCTGTGGGACAAGTTCAGTGAGCTGGCTACCAAGTGCATCATCAAG ATCGTGGAGTTTGCCAAGCGGTTGCCTGGCTTTACAGGGCTCAGCATTGCTGACCAGATC ACTCTGCTCAAAGCTGCCTGCCTAGATATCCTGATGCTGCGTATCTGCACAAGGTACACC CCAGAGCAGGACACCATGACCTTCTCCGACGGGCTGACCCTGAACCGGACCCAGATGCAC AATGCCGGCTTCGGGCCCCTCACAGACCTTGTCTTTGCCTTTGCTGGGCAGCTCCTGCCC CTGGAGATGGATGACACCGAGACAGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGAC CGCATGGACCTGGAGGAGCCCGAAAAAGTGGACAAGCTGCAGGAGCCACTGCTGGAAGCC CTGAGGCTGTACGCCCGGCGCCGGCGGCCCAGCCAGCCCTACATGTTCCCAAGGATGCTA ATGAAAATCACCGACCTCCGGGGCATCAGCACTAAGGGAGCTGAAAGGGCCATTACTCTG AAGATGGAGATTCCAGGCCCGATGCCTCCCTTAATCCGAGAGATGCTGGAGAACCCTGAA ATGTTTGAGGATGACTCCTCGCAGCCTGGTCCCCACCCCAATGCCTCTAGCGAGGATGAG GTTCCTGGGGGCCAGGGCAAAGGGGGCCTGAAGTCCCCAGCCTGA
- Chromosome Location
- 12
- Locus
- 12q13
- External Identifiers
Resource Link UniProtKB ID P13631 UniProtKB Entry Name RARG_HUMAN GenBank Protein ID 306887 GenBank Gene ID M24857 GenAtlas ID RARG HGNC ID HGNC:9866 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00459 Acitretin approved yes agonist Details DB00523 Alitretinoin approved, investigational yes agonist Details DB00755 Tretinoin approved, investigational, nutraceutical yes agonist Details DB00799 Tazarotene approved, investigational yes agonist Details DB00926 Etretinate withdrawn yes agonist Details DB02258 SR11254 experimental unknown Details DB02466 BMS-181156 experimental unknown Details DB02741 CD564 experimental unknown Details DB03279 Dodecyl-Alpha-D-Maltoside experimental unknown Details DB03466 BMS184394 experimental unknown Details DB05785 LGD-1550 investigational unknown Details DB07031 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid experimental unknown Details DB07294 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid experimental unknown Details DB00982 Isotretinoin approved unknown Details DB12808 Trifarotene approved, investigational yes agonist Details DB00210 Adapalene approved yes agonist Details DB05467 Palovarotene approved, investigational yes agonist Details