T-cell surface glycoprotein CD3 epsilon chain
Details
- Name
- T-cell surface glycoprotein CD3 epsilon chain
- Synonyms
- T-cell surface antigen T3/Leu-4 epsilon chain
- T3E
- Gene Name
- CD3E
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016054|T-cell surface glycoprotein CD3 epsilon chain MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQ HNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCE NCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERP PPVPNPDYEPIRKGQRDLYSGLNQRRI
- Number of residues
- 207
- Molecular Weight
- 23147.09
- Theoretical pI
- 6.75
- GO Classification
- Functionsprotein heterodimerization activity / protein kinase binding / receptor signaling complex scaffold activity / receptor signaling protein activity / SH3 domain binding / T cell receptor binding / transmembrane signaling receptor activityProcessesapoptotic signaling pathway / cell surface receptor signaling pathway / G-protein coupled receptor signaling pathway / intracellular signal transduction / negative regulation of gene expression / negative regulation of smoothened signaling pathway / negative thymic T cell selection / positive regulation of alpha-beta T cell proliferation / positive regulation of calcium-mediated signaling / positive regulation of gene expression / positive regulation of interferon-gamma production / positive regulation of interleukin-2 biosynthetic process / positive regulation of interleukin-4 production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of T cell anergy / positive regulation of T cell proliferation / protein complex assembly / regulation of apoptotic process / regulation of immune response / response to nutrient / signal complex assembly / T cell activation / T cell costimulation / T cell receptor signaling pathway / transmembrane receptor protein tyrosine kinase signaling pathwayComponentsalpha-beta T cell receptor complex / cell-cell junction / external side of plasma membrane / immunological synapse / integral component of plasma membrane / intracellular / plasma membrane / T cell receptor complex
- General Function
- Transmembrane signaling receptor activity
- Specific Function
- The CD3 complex mediates signal transduction, resulting in T cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).
- Pfam Domain Function
- ITAM (PF02189)
- Transmembrane Regions
- 127-152
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016055|T-cell surface glycoprotein CD3 epsilon chain (CD3E) ATGCAGTCGGGCACTCACTGGAGAGTTCTGGGCCTCTGCCTCTTATCAGTTGGCGTTTGG GGGCAAGATGGTAATGAAGAAATGGGTGGTATTACACAGACACCATATAAAGTCTCCATC TCTGGAACCACAGTAATATTGACATGCCCTCAGTATCCTGGATCTGAAATACTATGGCAA CACAATGATAAAAACATAGGCGGTGATGAGGATGATAAAAACATAGGCAGTGATGAGGAT CACCTGTCACTGAAGGAATTTTCAGAATTGGAGCAAAGTGGTTATTATGTCTGCTACCCC AGAGGAAGCAAACCAGAAGATGCGAACTTTTATCTCTACCTGAGGGCAAGAGTGTGTGAG AACTGCATGGAGATGGATGTGATGTCGGTGGCCACAATTGTCATAGTGGACATCTGCATC ACTGGGGGCTTGCTGCTGCTGGTTTACTACTGGAGCAAGAATAGAAAGGCCAAGGCCAAG CCTGTGACACGAGGAGCGGGTGCTGGCGGCAGGCAAAGGGGACAAAACAAGGAGAGGCCA CCACCTGTTCCCAACCCAGACTATGAGCCCATCCGGAAAGGCCAGCGGGACCTGTATTCT GGCCTGAATCAGAGACGCATCTGA
- Chromosome Location
- 11
- Locus
- 11q23
- External Identifiers
Resource Link UniProtKB ID P07766 UniProtKB Entry Name CD3E_HUMAN GenBank Protein ID 469945 GenBank Gene ID X03884 GenAtlas ID CD3E HGNC ID HGNC:1674 - General References
- Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C: Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex. Nature. 1986 May 22-28;321(6068):431-4. [Article]
- Clevers HC, Dunlap S, Wileman TE, Terhorst C: Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8156-60. [Article]
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- Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B: Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency. Nat Genet. 1993 Jan;3(1):77-81. [Article]
- Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):443-8. Epub 2003 Jan 9. [Article]
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- Gimferrer I, Calvo M, Mittelbrunn M, Farnos M, Sarrias MR, Enrich C, Vives J, Sanchez-Madrid F, Lozano F: Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol. 2004 Aug 15;173(4):2262-70. [Article]
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- Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J: Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00075 Muromonab approved, investigational yes binder Details DB06607 Catumaxomab approved, investigational, withdrawn yes agonist Details DB06606 Teplizumab approved, investigational yes antibody Details DB15434 Mosunetuzumab approved, investigational yes binder Details DB16672 Epcoritamab approved, investigational yes binderantibody Details DB16655 Teclistamab approved, investigational yes antibody Details DB16684 Odronextamab investigational yes binder Details DB16371 Glofitamab approved, investigational yes binderantibody Details DB15395 Elranatamab approved, investigational unknown antibody Details DB16678 Talquetamab approved, investigational yes antibody Details