Apolipoprotein C-III
Details
- Name
- Apolipoprotein C-III
- Synonyms
- Apo-CIII
- Apolipoprotein C3
- Gene Name
- APOC3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017855|Apolipoprotein C-III MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQAR GWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA
- Number of residues
- 99
- Molecular Weight
- 10852.19
- Theoretical pI
- Not Available
- GO Classification
- Functionscholesterol binding / enzyme regulator activity / high-density lipoprotein particle receptor binding / lipase inhibitor activity / phospholipid bindingProcessescholesterol efflux / cholesterol homeostasis / chylomicron remnant clearance / G-protein coupled receptor signaling pathway / high-density lipoprotein particle remodeling / lipoprotein metabolic process / negative regulation of cholesterol import / negative regulation of fatty acid biosynthetic process / negative regulation of high-density lipoprotein particle clearance / negative regulation of lipid catabolic process / negative regulation of lipid metabolic process / negative regulation of lipoprotein lipase activity / negative regulation of low-density lipoprotein particle clearance / negative regulation of receptor-mediated endocytosis / negative regulation of triglyceride catabolic process / negative regulation of very-low-density lipoprotein particle clearance / negative regulation of very-low-density lipoprotein particle remodeling / phospholipid efflux / phototransduction, visible light / regulation of Cdc42 protein signal transduction / retinoid metabolic process / reverse cholesterol transport / small molecule metabolic process / triglyceride catabolic process / triglyceride homeostasis / triglyceride metabolic process / very-low-density lipoprotein particle assemblyComponentschylomicron / early endosome / extracellular exosome / extracellular region / extracellular space / intermediate-density lipoprotein particle / spherical high-density lipoprotein particle / very-low-density lipoprotein particle
- General Function
- Phospholipid binding
- Specific Function
- Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.
- Pfam Domain Function
- Apo-CIII (PF05778)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017856|Apolipoprotein C-III (APOC3) ATGCAGCCCCGGGTACTCCTTGTTGTTGCCCTCCTGGCGCTCCTGGCCTCTGCCCGAGCT TCAGAGGCCGAGGATGCCTCCCTTCTCAGCTTCATGCAGGGTTACATGAAGCACGCCACC AAGACCGCCAAGGATGCACTGAGCAGCGTGCAGGAGTCCCAGGTGGCCCAGCAGGCCAGG GGCTGGGTGACCGATGGCTTCAGTTCCCTGAAAGACTACTGGAGCACCGTTAAGGACAAG TTCTCTGAGTTCTGGGATTTGGACCCTGAGGTCAGACCAACTTCAGCCGTGGCTGCCTGA
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P02656 UniProtKB Entry Name APOC3_HUMAN HGNC ID HGNC:610 - General References
- Protter AA, Levy-Wilson B, Miller J, Bencen G, White T, Seilhamer JJ: Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes. DNA. 1984 Dec;3(6):449-56. [Article]
- Levy-Wilson B, Appleby V, Protter A, Auperin D, Seilhamer JJ: Isolation and DNA sequence of full-length cDNA for human preapolipoprotein CIII. DNA. 1984 Oct;3(5):359-64. [Article]
- Karathanasis SK, Zannis VI, Breslow JL: Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles. J Lipid Res. 1985 Apr;26(4):451-6. [Article]
- Sharpe CR, Sidoli A, Shelley CS, Lucero MA, Shoulders CC, Baralle FE: Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance. Nucleic Acids Res. 1984 May 11;12(9):3917-32. [Article]
- Fullerton SM, Buchanan AV, Sonpar VA, Taylor SL, Smith JD, Carlson CS, Salomaa V, Stengard JH, Boerwinkle E, Clark AG, Nickerson DA, Weiss KM: The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster. Hum Genet. 2004 Jun;115(1):36-56. Epub 2004 Apr 24. [Article]
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- Hospattankar AV, Brewer HB Jr, Ronan R, Fairwell T: Amino acid sequence of human plasma apolipoprotein C-III from normolipidemic subjects. FEBS Lett. 1986 Mar 3;197(1-2):67-73. [Article]
- Brewer HB Jr, Shulman R, Herbert P, Ronan R, Wehrly K: The complete amino acid sequence of alanine apolipoprotein (apoC-3), and apolipoprotein from human plasma very low density lipoproteins. J Biol Chem. 1974 Aug 10;249(15):4975-84. [Article]
- Chan DC, Chen MM, Ooi EM, Watts GF: An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor? Int J Clin Pract. 2008 May;62(5):799-809. doi: 10.1111/j.1742-1241.2007.01678.x. Epub 2008 Jan 14. [Article]
- Nilsson J, Ruetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G: Enrichment of glycopeptides for glycan structure and attachment site identification. Nat Methods. 2009 Nov;6(11):809-11. doi: 10.1038/nmeth.1392. Epub 2009 Oct 18. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Yao Z, Wang Y: Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production. Curr Opin Lipidol. 2012 Jun;23(3):206-12. doi: 10.1097/MOL.0b013e328352dc70. [Article]
- Nicolardi S, van der Burgt YE, Dragan I, Hensbergen PJ, Deelder AM: Identification of new apolipoprotein-CIII glycoforms with ultrahigh resolution MALDI-FTICR mass spectrometry of human sera. J Proteome Res. 2013 May 3;12(5):2260-8. doi: 10.1021/pr400136p. Epub 2013 Apr 5. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Maeda H, Hashimoto RK, Ogura T, Hiraga S, Uzawa H: Molecular cloning of a human apoC-III variant: Thr 74----Ala 74 mutation prevents O-glycosylation. J Lipid Res. 1987 Dec;28(12):1405-9. [Article]
- von Eckardstein A, Holz H, Sandkamp M, Weng W, Funke H, Assmann G: Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia. J Clin Invest. 1991 May;87(5):1724-31. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB09130 Copper approved, investigational unknown Details DB15067 Volanesorsen approved, investigational yes inhibitorantisense oligonucleotide Details DB11886 Infigratinib approved, investigational no binder Details DB00877 Sirolimus approved, investigational no binder Details