Uridine phosphorylase 2
Details
- Name
- Uridine phosphorylase 2
- Synonyms
- 2.4.2.3
- UPase 2
- Gene Name
- UPP2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004825|Uridine phosphorylase 2 MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVK FVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPS ISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDN IVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLD YLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQR PQLLISNFIRRRLGLCD
- Number of residues
- 317
- Molecular Weight
- 35526.93
- Theoretical pI
- 6.66
- GO Classification
- Functionsuridine phosphorylase activityProcessesnucleobase-containing small molecule metabolic process / nucleoside metabolic process / nucleotide catabolic process / pyrimidine nucleobase metabolic process / pyrimidine nucleoside catabolic process / pyrimidine nucleoside salvage / small molecule metabolic process / UMP salvage / uridine metabolic processComponentscytosol / type III intermediate filament
- General Function
- Uridine phosphorylase activity
- Specific Function
- Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
- Pfam Domain Function
- PNP_UDP_1 (PF01048)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016797|Uridine phosphorylase 2 (UPP2) ATGCTGGCCCCAGGCTGTGAGTTGGACCCAGACCAAGAAGTGGTGAGGACAAGGCCTGAA GATGTGCCTGCTTCCCCTTCAACTTCCACCATGATTGTAAGTGTCCTGAGGCCTCCCAGC CATGCTTCCTGTACAGCCTGTGGAACTGTGACTTTTCACATAGTAGAGAGAATGGCTTCA GTTATACCTGCCTCCAATAGGTCCATGAGATCTGACAGGAATACATATGTTGGAAAAAGG TTTGTTCACGTTAAAAATCCTTACTTGGATTTGATGGATGAAGACATTCTCTATCACTTG GATTTGGGAACAAAAACACACAACCTACCAGCAATGTTTGGAGATGTAAAGTTTGTCTGT GTCGGTGGGAGCCCCAACAGAATGAAAGCATTTGCACTGTTTATGCACAAGGAGCTCGGG TTTGAGGAAGCTGAAGAAGACATAAAAGACATCTGTGCTGGGACAGACAGATACTGTATG TACAAAACCGGGCCTGTGCTCGCCATCAGTCACGGCATGGGCATCCCCTCCATTTCTATT ATGCTTCATGAACTCATCAAATTACTCCACCATGCACGGTGCTGCGATGTCACCATTATT AGAATCGGTACATCAGGGGGAATAGGGATTGCACCAGGGACTGTTGTAATAACGGATATA GCTGTAGACTCCTTCTTTAAGCCCCGGTTTGAACAGGTCATTTTGGACAACATTGTCACC CGAAGTACTGAACTGGACAAAGAACTGTCTGAAGAACTGTTCAACTGTAGCAAAGAAATC CCCAACTTCCCAACCCTCGTTGGACATACAATGTGTACCTATGATTTTTATGAAGGCCAA GGCCGACTAGATGGAGCACTGTGCTCCTTTTCCAGAGAAAAAAAGTTAGACTACTTGAAG AGAGCATTTAAAGCTGGTGTCAGGAATATTGAAATGGAATCTACAGTGTTTGCAGCTATG TGTGGACTCTGTGGTCTAAAAGCTGCTGTGGTCTGTGTGACACTTCTCGACAGACTCGAC TGTGATCAGATCAACTTGCCTCATGATGTCCTGGTGGAGTACCAGCAACGGCCTCAGCTC CTAATCTCCAACTTCATCAGACGGCGGCTTGGACTTTGTGACTAG
- Chromosome Location
- 2
- Locus
- 2q24.1
- External Identifiers
Resource Link UniProtKB ID O95045 UniProtKB Entry Name UPP2_HUMAN GenBank Gene ID AY225131 GenAtlas ID UPP2 HGNC ID HGNC:23061 - General References
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