Beta-1,4-galactosyltransferase 2
Details
- Name
- Beta-1,4-galactosyltransferase 2
- Synonyms
- 2.4.1.-
- Beta-1,4-GalTase 2
- UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2
- UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2
- Gene Name
- B4GALT2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004444|Beta-1,4-galactosyltransferase 2 MSRLLGGTLERVCKAVLLLCLLHFLVAVILYFDVYAQHLAFFSRFSARGPAHALHPAASS SSSSSNCSRPNATASSSGLPEVPSALPGPTAPTLPPCPDSPPGLVGRLLIEFTSPMPLER VQRENPGVLMGGRYTPPDCTPAQTVAVIIPFRHREHHLRYWLHYLHPILRRQRLRYGVYV INQHGEDTFNRAKLLNVGFLEALKEDAAYDCFIFSDVDLVPMDDRNLYRCGDQPRHFAIA MDKFGFRLPYAGYFGGVSGLSKAQFLRINGFPNEYWGWGGEDDDIFNRISLTGMKISRPD IRIGRYRMIKHDRDKHNEPNPQRFTKIQNTKLTMKRDGIGSVRYQVLEVSRQPLFTNITV DIGRPPSWPPRG
- Number of residues
- 372
- Molecular Weight
- 41971.815
- Theoretical pI
- 9.66
- GO Classification
- Functionsbeta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity / galactosyltransferase activity / lactose synthase activity / metal ion binding / N-acetyllactosamine synthase activityProcessescarbohydrate metabolic process / cellular protein metabolic process / glycosaminoglycan metabolic process / keratan sulfate biosynthetic process / keratan sulfate metabolic process / post-translational protein modification / protein N-linked glycosylation via asparagine / small molecule metabolic processComponentsGolgi cisterna membrane / Golgi membrane / integral component of membrane
- General Function
- N-acetyllactosamine synthase activity
- Specific Function
- Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.
- Pfam Domain Function
- Transmembrane Regions
- 16-36
- Cellular Location
- Golgi apparatus
- Gene sequence
>lcl|BSEQ0021320|Beta-1,4-galactosyltransferase 2 (B4GALT2) ATGAGCAGACTGCTGGGGGGGACGCTGGAGCGCGTCTGCAAGGCTGTGCTCCTTCTCTGC CTGCTGCACTTCCTCGTGGCCGTCATCCTCTACTTTGACGTCTACGCCCAGCACCTGGCC TTCTTCAGCCGCTTCAGTGCCCGAGGCCCTGCCCATGCCCTCCACCCAGCTGCTAGCAGC AGCAGCAGCAGCAGCAACTGCTCCCGGCCCAACGCCACCGCCTCTAGCTCCGGGCTCCCT GAGGTCCCCAGTGCCCTGCCCGGTCCCACGGCTCCCACGCTGCCACCCTGTCCTGACTCG CCACCTGGTCTTGTGGGCAGACTGCTGATCGAGTTCACCTCACCCATGCCCCTGGAGCGG GTGCAGAGGGAGAACCCAGGCGTGCTCATGGGCGGCCGATACACACCGCCCGACTGCACC CCAGCCCAGACGGTGGCGGTCATCATCCCCTTTAGACACCGGGAACACCACCTGCGCTAC TGGCTCCACTATCTACACCCCATCTTGAGGCGGCAGCGGCTGCGCTACGGCGTCTATGTC ATCAACCAGCATGGTGAGGACACCTTCAACCGGGCCAAGCTGCTTAACGTGGGCTTCCTA GAGGCGCTGAAGGAGGATGCCGCCTATGACTGCTTCATCTTCAGCGATGTGGACCTGGTC CCCATGGATGACCGCAACCTATACCGCTGCGGCGACCAACCCCGCCACTTTGCCATTGCC ATGGACAAGTTTGGCTTCCGGCTTCCCTATGCTGGCTACTTTGGAGGTGTGTCAGGCCTG AGTAAGGCTCAGTTTCTGAGAATCAATGGCTTCCCCAATGAGTACTGGGGCTGGGGTGGC GAGGATGATGACATCTTCAACCGGATCTCCCTGACTGGGATGAAGATCTCACGCCCAGAC ATCCGAATCGGCCGCTACCGCATGATCAAGCACGACCGCGACAAGCATAACGAACCTAAC CCTCAGAGGTTTACCAAGATTCAAAACACGAAGCTGACCATGAAGCGGGACGGCATTGGG TCAGTGCGGTACCAGGTCTTGGAGGTGTCTCGGCAACCACTCTTCACCAATATCACAGTG GACATTGGGCGGCCTCCGTCGTGGCCCCCTCGGGGCTGA
- Chromosome Location
- 1
- Locus
- 1p34-p33
- External Identifiers
Resource Link UniProtKB ID O60909 UniProtKB Entry Name B4GT2_HUMAN GenBank Protein ID 2995442 GenBank Gene ID Y12510 GenAtlas ID B4GALT2 HGNC ID HGNC:925 - General References
- Almeida R, Amado M, David L, Levery SB, Holmes EH, Merkx G, van Kessel AG, Rygaard E, Hassan H, Bennett E, Clausen H: A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3. J Biol Chem. 1997 Dec 19;272(51):31979-91. [Article]
- Lo NW, Shaper JH, Pevsner J, Shaper NL: The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. 1998 May;8(5):517-26. [Article]
- Guo S, Sato T, Shirane K, Furukawa K: Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells. Glycobiology. 2001 Oct;11(10):813-20. [Article]
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Drug Relations
- Drug Relations
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