Monocarboxylate transporter 2
Details
- Name
- Monocarboxylate transporter 2
- Synonyms
- MCT 2
- MCT2
- Solute carrier family 16 member 7
- Gene Name
- SLC16A7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010306|Monocarboxylate transporter 2 MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAW ISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFIT GLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLI LGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFS LFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSV GLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFE TLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW LLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI
- Number of residues
- 478
- Molecular Weight
- 52199.745
- Theoretical pI
- 9.68
- GO Classification
- Functionslactate transmembrane transporter activity / pyruvate secondary active transmembrane transporter activity / pyruvate transmembrane transporter activity / symporter activityProcesseslactate transmembrane transport / plasma membrane lactate transport / pyruvate transmembrane transport / transmembrane transportComponentscytoplasm / integral component of plasma membrane / plasma membrane
- General Function
- Symporter activity
- Specific Function
- Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 16-36 60-80 90-110 116-136 149-169 174-194 247-267 283-303 313-333 339-359 374-394 407-427
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010307|Monocarboxylate transporter 2 (SLC16A7) ATGCCACCAATGCCAAGTGCCCCACCTGTGCATCCACCTCCAGATGGAGGATGGGGTTGG ATTGTGGTTGGAGCAGCTTTTATCTCCATTGGATTTTCCTATGCATTCCCCAAAGCTGTC ACCGTATTCTTCAAAGAAATTCAGCAAATATTCCACACTACCTACAGTGAAATAGCATGG ATTTCATCCATTATGCTGGCTGTTATGTACGCAGGAGGTCCTGTAAGTAGTGTTTTGGTG AATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATG GTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACA GGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATACTTCTAT AGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCA TTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATT TTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTTGGACCC AATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCA AAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCC CTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTCCTAGGT TTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTAC TCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTA GGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGTTTTGCA ATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTG GTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAA ACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTCACAATT GTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACT GGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGG CTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAGGAAAAT GCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTT AACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAA
- Chromosome Location
- 12
- Locus
- 12q13
- External Identifiers
Resource Link UniProtKB ID O60669 UniProtKB Entry Name MOT2_HUMAN GenBank Protein ID 3047402 GenBank Gene ID AF058056 GenAtlas ID SLC16A7 HGNC ID HGNC:10928 - General References
- Lin RY, Vera JC, Chaganti RS, Golde DW: Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998 Oct 30;273(44):28959-65. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00119 Pyruvic acid approved, investigational, nutraceutical unknown Details DB03066 D-Lactic acid experimental unknown inhibitor Details DB04398 Lactic acid approved, vet_approved unknown substrateinhibitor Details DB03773 alpha-D-quinovopyranose experimental unknown inhibitor Details DB01440 gamma-Hydroxybutyric acid approved, illicit, investigational unknown inhibitor Details DB04216 Quercetin experimental, investigational unknown inhibitor Details DB01032 Probenecid approved, investigational unknown inhibitor Details DB04552 Niflumic acid experimental unknown inhibitor Details DB01762 Acetoacetic acid experimental unknown inhibitor Details DB00119 Pyruvic acid approved, investigational, nutraceutical unknown substrateinhibitor Details DB04074 alpha-Ketoisovalerate experimental unknown inhibitor Details