Florzolotau F-18
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Florzolotau F-18
- DrugBank Accession Number
- DB16297
- Background
PMPBB3 F-18 is under investigation in clinical trial NCT04305210 (Alzheimer's Disease: Clinical Investigation and Neuroimage Studies Including 18F-PM-PBB3 and 18f-florbetapir (AV-45) PET Examination).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 384.46
Monoisotopic: 384.128560737 - Chemical Formula
- C20H20FN3O2S
- Synonyms
- Not Available
- External IDs
- (18F) MNI-958
- APN-1607 F-18
- F-18 PMPBB3
- MNI-958 F-18
- PMPBB3 F-18
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 51M993JIQ4
- CAS number
- 1565797-57-0
- InChI Key
- XXNYLYXTRMQXJS-CDLXMPELSA-N
- InChI
- InChI=1S/C20H20FN3O2S/c1-22-19-9-6-14(12-23-19)4-2-3-5-20-24-17-8-7-16(10-18(17)27-20)26-13-15(25)11-21/h2-10,12,15,25H,11,13H2,1H3,(H,22,23)/b4-2+,5-3+/i21-1
- IUPAC Name
- 1-(¹⁸F)fluoro-3-({2-[(1E,3E)-4-[6-(methylamino)pyridin-3-yl]buta-1,3-dien-1-yl]-1,3-benzothiazol-6-yl}oxy)propan-2-ol
- SMILES
- CNC1=CC=C(\C=C\C=C\C2=NC3=C(S2)C=C(OCC(O)C[18F])C=C3)C=N1
References
- General References
- Not Available
- External Links
- ChemSpider
- 81367183
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Recruiting Diagnostic Alzheimer's Disease (AD) 1 2 Unknown Status Diagnostic Alzheimer's Disease (AD) 1 0 Completed Diagnostic Alzheimer's Disease (AD) / Cortical Basal Syndrome (CBS) / Frontal Temporal Dementia (FTD) / Progressive Supranuclear Palsy (PSP) / Vascular Cognitive Impairment 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00193 mg/mL ALOGPS logP 4.24 ALOGPS logP 3.47 Chemaxon logS -5.3 ALOGPS pKa (Strongest Acidic) 13.35 Chemaxon pKa (Strongest Basic) 6.33 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 67.27 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 107.68 m3·mol-1 Chemaxon Polarizability 42.41 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-014r-0009000000-b94c44ee6726c5194b1a Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-2009000000-db93342acf16fe638c91 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-05n0-0009000000-560358bfffa360c4d47d Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0aor-3019000000-83045b862ee4fae76000 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-08mi-0519000000-237c485839383fd80429 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-0392000000-5a8f1564a59a47d84bb4 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 15, 2020 18:18 / Updated at June 25, 2023 04:56