Mephenoxalone
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Mephenoxalone is a muscle relaxant indicated in the treatment of painful muscle spasms and cramps.
- Generic Name
- Mephenoxalone
- DrugBank Accession Number
- DB13754
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 223.228
Monoisotopic: 223.084457903 - Chemical Formula
- C11H13NO4
- Synonyms
- Mefenoxalona
- Mephenoxalone
- Mephenoxalonum
- External IDs
- AHR 233
- CL 27,319
- OM 518
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Muscle spasms Combination Product in combination with: Acetaminophen (DB00316) •••••••••••• •••••• Used in combination to treat Pain Combination Product in combination with: Acetaminophen (DB00316) •••••••••••• •••••• Used in combination for symptomatic treatment of Pain Combination Product in combination with: Acetaminophen (DB00316) •••••••••••• •••••• - Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Mephenoxalone. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Mephenoxalone. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Mephenoxalone. Agomelatine The risk or severity of CNS depression can be increased when Agomelatine is combined with Mephenoxalone. Alfentanil The risk or severity of CNS depression can be increased when Alfentanil is combined with Mephenoxalone. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Dorsilon / Lenetran / Placidex / Riself / Transpoise / Valanas / Xerene
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image DORSILON TABLET, 1000 ADET Mephenoxalone (200 mg) + Acetaminophen (450 mg) Tablet SANDOZ İLAÇ SAN. VE TİC. A.Ş. 1991-09-11 Not applicable Turkey DORSILON TABLET, 20 ADET Mephenoxalone (200 mg) + Acetaminophen (450 mg) Tablet SANDOZ İLAÇ SAN. VE TİC. A.Ş. 1991-09-11 Not applicable Turkey DORSILON TABLET, 60 ADET Mephenoxalone (200 mg) + Acetaminophen (450 mg) Tablet SANDOZ İLAÇ SAN. VE TİC. A.Ş. 1991-09-11 Not applicable Turkey
Categories
- ATC Codes
- N05BX01 — Mephenoxalone
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Phenol ethers
- Sub Class
- Anisoles
- Direct Parent
- Anisoles
- Alternative Parents
- Phenoxy compounds / Methoxybenzenes / Alkyl aryl ethers / Oxazolidinones / Carbamate esters / Organic carbonic acids and derivatives / Oxacyclic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds show 3 more
- Substituents
- Alkyl aryl ether / Anisole / Aromatic heteromonocyclic compound / Azacycle / Carbamic acid ester / Carbonic acid derivative / Carbonyl group / Ether / Hydrocarbon derivative / Methoxybenzene show 12 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- CZ87T54W8W
- CAS number
- 70-07-5
- InChI Key
- ZMNSRFNUONFLSP-UHFFFAOYSA-N
- InChI
- InChI=1S/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13)
- IUPAC Name
- 5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
- SMILES
- COC1=C(OCC2CNC(=O)O2)C=CC=C1
References
- General References
- TITCK Product Information: Dorsilon (acetaminophen/mephenoxalone) oral tablets [Link]
- External Links
- ChemSpider
- 6021
- ChEBI
- 134916
- ChEMBL
- CHEMBL2104790
- Wikipedia
- Mephenoxalone
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 4.93 mg/mL ALOGPS logP 0.8 ALOGPS logP 1.19 Chemaxon logS -1.7 ALOGPS pKa (Strongest Acidic) 12.68 Chemaxon pKa (Strongest Basic) -4.6 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 56.79 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 55.7 m3·mol-1 Chemaxon Polarizability 22.22 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 144.72014 predictedDeepCCS 1.0 (2019) [M+H]+ 147.26445 predictedDeepCCS 1.0 (2019) [M+Na]+ 155.8637 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:48 / Updated at May 22, 2021 06:01