Cefatrizine
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Cefatrizine
- DrugBank Accession Number
- DB13266
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 462.5
Monoisotopic: 462.078010052 - Chemical Formula
- C18H18N6O5S2
- Synonyms
- cefatrizina
- céfatrizine
- Cefatrizine
- cefatrizinum
- External IDs
- antibiotic BL-S 640
- BL-S 640
- BL-S640
- BLS 640
- S-640P
- SKF 60771
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Cefatrizine may decrease the excretion rate of Abacavir which could result in a higher serum level. Abciximab The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefatrizine. Aceclofenac The risk or severity of nephrotoxicity can be increased when Aceclofenac is combined with Cefatrizine. Acemetacin The risk or severity of nephrotoxicity can be increased when Cefatrizine is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding can be increased when Cefatrizine is combined with Acenocoumarol. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Cefatrizine propylene glycolate 3731IA5GI9 64217-62-5 CKOIKOHDEYTLFR-PFBPGKLMSA-N
Categories
- ATC Codes
- J01DB07 — Cefatrizine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as cephalosporins. These are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid moiety or a derivative thereof.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Lactams
- Sub Class
- Beta lactams
- Direct Parent
- Cephalosporins
- Alternative Parents
- N-acyl-alpha amino acids and derivatives / Alpha amino acid amides / Phenylacetamides / 1-hydroxy-2-unsubstituted benzenoids / Alkylarylthioethers / Aralkylamines / 1,3-thiazines / Triazoles / Tertiary carboxylic acid amides / Heteroaromatic compounds show 14 more
- Substituents
- 1,2,3-triazole / 1-hydroxy-2-unsubstituted benzenoid / Alkylarylthioether / Alpha-amino acid amide / Alpha-amino acid or derivatives / Amine / Amino acid / Amino acid or derivatives / Aralkylamine / Aromatic heteropolycyclic compound show 33 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 8P4W949T8K
- CAS number
- 51627-14-6
- InChI Key
- UOCJDOLVGGIYIQ-PBFPGSCMSA-N
- InChI
- InChI=1S/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12-,13-,17-/m1/s1
- IUPAC Name
- (6R,7R)-7-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-[(1H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- SMILES
- [H][C@@]1(NC(=O)[C@H](N)C2=CC=C(O)C=C2)C(=O)N2C(C(O)=O)=C(CSC3=CNN=N3)CS[C@]12[H]
References
- General References
- Not Available
- External Links
- KEGG Drug
- D02406
- ChemSpider
- 4918615
- 2179
- ChEBI
- 131730
- ChEMBL
- CHEMBL1095284
- ZINC
- ZINC000003830404
- Wikipedia
- Cefatrizine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Tablet Tablet, coated Granule, for suspension Oral Capsule 500 MG - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.149 mg/mL ALOGPS logP -0.28 ALOGPS logP -2.2 Chemaxon logS -3.5 ALOGPS pKa (Strongest Acidic) 2.92 Chemaxon pKa (Strongest Basic) 7.22 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 174.53 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 115.69 m3·mol-1 Chemaxon Polarizability 42.34 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0040900000-3d03939b82a085d58ed4 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-08fs-4597700000-3f81ac983a25fa02cfab Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-08mi-0954600000-2652692219cc81fd0111 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-00ls-9035600000-d87a000f9c03b350915b Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-00e9-0941300000-6cf34a5e7230b9a2f145 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-00di-6900100000-989be08cb9afb372656e Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 218.6320634 predictedDarkChem Lite v0.1.0 [M-H]- 200.40317 predictedDeepCCS 1.0 (2019) [M+H]+ 217.6820634 predictedDarkChem Lite v0.1.0 [M+H]+ 202.2989 predictedDeepCCS 1.0 (2019) [M+Na]+ 208.14873 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:38 / Updated at February 21, 2021 18:54