Nefopam
Star1
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Nefopam is a non-opioid analgesic used for moderate to severe pain, especially post-surgical pain.
- Generic Name
- Nefopam
- DrugBank Accession Number
- DB12293
- Background
Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
- Weight
- Average: 253.345
Monoisotopic: 253.146664236 - Chemical Formula
- C17H19NO
- Synonyms
- Nefopam
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Pain •••••••••••• •••••••••• ••••••••• •••••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareMorphine The therapeutic efficacy of Morphine can be increased when used in combination with Nefopam. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Nefopam hydrochloride 685J48E13W 23327-57-3 CNNVSINJDJNHQK-UHFFFAOYSA-N
Categories
- ATC Codes
- N02BG06 — Nefopam
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
- Kingdom
- Organic compounds
- Super Class
- Organic nitrogen compounds
- Class
- Organonitrogen compounds
- Sub Class
- Amines
- Direct Parent
- Aralkylamines
- Alternative Parents
- Benzene and substituted derivatives / Trialkylamines / Oxacyclic compounds / Dialkyl ethers / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Dialkyl ether / Ether / Hydrocarbon derivative / Monocyclic benzene moiety / Organic oxygen compound / Organoheterocyclic compound
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4UP8060B7J
- CAS number
- 13669-70-0
- InChI Key
- RGPDEAGGEXEMMM-UHFFFAOYSA-N
- InChI
- InChI=1S/C17H19NO/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18/h2-10,17H,11-13H2,1H3
- IUPAC Name
- 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine
- SMILES
- CN1CCOC(C2=CC=CC=C2)C2=CC=CC=C2C1
References
- General References
- INVIMA Product Authorization: Katamox (nefopam hydrochloride) injectable solution [Link]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Postoperative pain 1 4 Recruiting Prevention Adverse Effects in the Therapeutic Use of Anaesthetics / Shivering 1 4 Terminated Treatment Postoperative Analgesia 1 4 Unknown Status Prevention Gallbladder Inflammation 1 4 Unknown Status Treatment Renal Colic 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intramuscular; Intravenous 20 mg/1ml Solution Intramuscular; Intravenous 20 mg Solution Intramuscular; Intravenous Solution Intramuscular 20 mg Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0803 mg/mL ALOGPS logP 3.16 ALOGPS logP 3.4 Chemaxon logS -3.5 ALOGPS pKa (Strongest Basic) 7.72 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 12.47 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 78.48 m3·mol-1 Chemaxon Polarizability 29.09 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0udi-0090000000-d615d88ca7a2d989ef60 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0udi-0090000000-a3da58efff446fe81400 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0udi-1290000000-55a4914f77fa1a7805c7 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-02t9-1960000000-beb84283a1cd8aa432a7 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0006-9500000000-6872fd1610e7227c5735 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-3900000000-e115eeb6f1fab677a0c2 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 153.82016 predictedDeepCCS 1.0 (2019) [M+H]+ 156.17818 predictedDeepCCS 1.0 (2019) [M+Na]+ 162.27132 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 21:51 / Updated at May 27, 2021 03:04