Dexmecamylamine
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Dexmecamylamine
- DrugBank Accession Number
- DB11807
- Background
Dexmecamylamine has been used in trials studying the basic science and treatment of Patients, Depression, Drug Abuse, Pharmacokinetics, and Renal Impairment, among others.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 167.296
Monoisotopic: 167.16739968 - Chemical Formula
- C11H21N
- Synonyms
- Dexmecamylamine
- External IDs
- TC-5214
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Dexmecamylamine Hydrochloride W3079LM7E7 107596-30-5 PKVZBNCYEICAQP-GSTSRXQZSA-N
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as bicyclic monoterpenoids. These are monoterpenoids containing exactly 2 rings, which are fused to each other.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Prenol lipids
- Sub Class
- Monoterpenoids
- Direct Parent
- Bicyclic monoterpenoids
- Alternative Parents
- Dialkylamines / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Aliphatic homopolycyclic compound / Amine / Bicyclic monoterpenoid / Hydrocarbon derivative / Organic nitrogen compound / Organonitrogen compound / Organopnictogen compound / Secondary aliphatic amine / Secondary amine
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 5Y1141YI4U
- CAS number
- 107538-05-6
- InChI Key
- IMYZQPCYWPFTAG-NGZCFLSTSA-N
- InChI
- InChI=1S/C11H21N/c1-10(2)8-5-6-9(7-8)11(10,3)12-4/h8-9,12H,5-7H2,1-4H3/t8-,9+,11-/m0/s1
- IUPAC Name
- (1R,2S,4S)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine
- SMILES
- CN[C@@]1(C)[C@@H]2CC[C@@H](C2)C1(C)C
References
- General References
- Not Available
- External Links
- PubChem Compound
- 12358972
- PubChem Substance
- 347828154
- ChemSpider
- 28528374
- BindingDB
- 50045047
- ChEMBL
- CHEMBL2103881
- ZINC
- ZINC000043763856
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Depression / Major Depressive Disorder (MDD) 4 3 Completed Treatment Major Depressive Disorder (MDD) 1 2 Active Not Recruiting Treatment Hyperhidrosis / Palmar Hyperhidrosis 1 2 Completed Treatment Depression / Major Depressive Disorder (MDD) 1 2 Completed Treatment Overactive Bladder Syndrome (OABS) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.124 mg/mL ALOGPS logP 3.13 ALOGPS logP 2.37 Chemaxon logS -3.1 ALOGPS pKa (Strongest Basic) 10.88 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 51.83 m3·mol-1 Chemaxon Polarizability 20.71 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-1000-7900000000-b4810454af19b865d662 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0900000000-c99171f61db55fc3dcc7 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-0900000000-5f33c2bf46cd918a029f Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-0900000000-8301ead1142ffc12f981 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-05r0-4900000000-b4e9fdf65a577bd93c4e Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-0900000000-85e036f17e86ecb0567b Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-00lf-9200000000-5116aa056eedf037d105 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 146.51225 predictedDeepCCS 1.0 (2019) [M+H]+ 148.90782 predictedDeepCCS 1.0 (2019) [M+Na]+ 154.82034 predictedDeepCCS 1.0 (2019)
Drug created at October 20, 2016 20:49 / Updated at February 21, 2021 18:53