Cambendazole
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Cambendazole
- DrugBank Accession Number
- DB11380
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental, Vet approved
- Structure
- Weight
- Average: 302.35
Monoisotopic: 302.083746881 - Chemical Formula
- C14H14N4O2S
- Synonyms
- Cambendazol
- Cambendazole
- Cambendazolum
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareMethotrexate The excretion of Methotrexate can be decreased when combined with Cambendazole. - Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzimidazoles
- Sub Class
- Not Available
- Direct Parent
- Benzimidazoles
- Alternative Parents
- Benzenoids / Thiazoles / Imidazoles / Heteroaromatic compounds / Propargyl-type 1,3-dipolar organic compounds / Carboximidic acids and derivatives / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds show 1 more
- Substituents
- Aromatic heteropolycyclic compound / Azacycle / Azole / Benzenoid / Benzimidazole / Carboximidic acid derivative / Heteroaromatic compound / Hydrocarbon derivative / Imidazole / Organic 1,3-dipolar compound show 7 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 079X63S3DU
- CAS number
- 26097-80-3
- InChI Key
- QZWHWHNCPFEXLL-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)
- IUPAC Name
- propan-2-yl N-[2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazol-5-yl]carbamate
- SMILES
- CC(C)OC(=O)NC1=CC2=C(NC(=N2)C2=CSC=N2)C=C1
References
- General References
- VandenHeuvel WJ, Wolf DE, Arison BH, Buhs RP, Carlin JR, Ellsworth RL, Jacob TA, Koniuszy FR, Smith JL, Trenner NR, Walker RW, Wolf FJ: Urinary metabolites of cambendazole. J Agric Food Chem. 1978 Nov-Dec;26(6):1357-64. [Article]
- Hogg RA: Death after cambendazole dosing. Vet Rec. 1978 Nov 18;103(21):477. [Article]
- Main DC, Vass DE: Cambendazole toxicity in calves. Aust Vet J. 1980 May;56(5):237-8. [Article]
- Rosegay A: 4-Thio derivatives of cambendazole. Drug Metab Dispos. 1980 May-Jun;8(3):136-8. [Article]
- Baker NF, Walters GT: Anthelmintic efficacy of cambendazole in cattle. Am J Vet Res. 1971 Jan;32(1):29-33. [Article]
- Baer JE, Jacob TA, Wolf FJ: Cambendazole and nondrug macromolecules in tissue residues. J Toxicol Environ Health. 1977 Mar;2(4):895-903. [Article]
- Cook RW: Cambendazole paste as an anthelmintic in horses. Vet Med Small Anim Clin. 1975 Dec;70(12):1451-3. [Article]
- Cairns GC, Holmden JH: The anthelmintic efficacy of cambendazole in horses. N Z Vet J. 1977 Jan-Feb;25(1-2):35-7. [Article]
- Amann RP, Bowen JM, Pickett BW, Berndtson WE, Stashak RS, Voss JL: Reproductive function in stallions treated with cambendazole. J Am Vet Med Assoc. 1977 Apr 1;170(7):730-2. [Article]
- Nekipelova RA, Papikhina KM, Gordeev IuS, Aryngazin S: [Effectiveness of cambendazole against intestinal nematodes]. Veterinariia. 1979 Sep;(9):45-6. [Article]
- External Links
- KEGG Drug
- D03340
- ChemSpider
- 30767
- 1951
- ChEMBL
- CHEMBL290578
- ZINC
- ZINC000005424098
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0211 mg/mL ALOGPS logP 3.06 ALOGPS logP 2.96 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 10.21 Chemaxon pKa (Strongest Basic) 3.93 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 79.9 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 90.56 m3·mol-1 Chemaxon Polarizability 32.31 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0udi-0019000000-f5d30b9d6008b3f99162 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0pb9-8194000000-1df47b1cf88e433885cb Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0092000000-fdb1dce122eaa2901c3d Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-2091000000-af582360def61e19ff15 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-014l-0090000000-1aaa49c77b433d0f40d8 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-01ox-3490000000-492b296b32dc4d20dcfb Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 179.6321665 predictedDarkChem Lite v0.1.0 [M-H]- 171.51938 predictedDeepCCS 1.0 (2019) [M+H]+ 179.8242665 predictedDarkChem Lite v0.1.0 [M+H]+ 173.8774 predictedDeepCCS 1.0 (2019) [M+Na]+ 179.9760665 predictedDarkChem Lite v0.1.0 [M+Na]+ 179.97055 predictedDeepCCS 1.0 (2019)
Drug created at February 25, 2016 18:17 / Updated at February 21, 2021 18:53