Trypsin
Identification
- Summary
Trypsin is a naturally occurring proteolytic enzyme found in the digestive tract of mammals. Used clinically in combination with bromelain and rutosides in the treatment of some inflammatory conditions.
- Generic Name
- Trypsin
- DrugBank Accession Number
- DB11237
- Background
Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine. Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate 1. This nucleophilic attack is facilitated by the catalytic triad consisting of histidine-57, aspartate-102, and serine-195. Trypsin also contains an oxyanion hole that stabilizes the charge negative charge on the carbonyl oxygen atom formed from the cleavage of peptide bonds. Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Synonyms
- Tripsina
- Trypsin
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination for symptomatic treatment of Inflammatory reaction of the genitourinary tract Combination Product in combination with: Rutin (DB01698), Bromelains (DB13281) •••••••••••• •••••• Used in combination for symptomatic treatment of Osteoarthritis (oa) Combination Product in combination with: Bromelains (DB13281), Rutin (DB01698) •••••••••••• •••••• Used in combination for symptomatic treatment of Thrombophlebitis Combination Product in combination with: Bromelains (DB13281), Rutin (DB01698) •••••••••••• •••••• Used in combination for symptomatic treatment of Traumatic injuries Combination Product in combination with: Rutin (DB01698), Bromelains (DB13281) •••••••••••• •••••• Used in combination for symptomatic treatment of Localized soft tissue rheumatism Combination Product in combination with: Rutin (DB01698), Bromelains (DB13281) •••••••••••• •••••• - Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetylcysteine The therapeutic efficacy of Acetylcysteine can be decreased when used in combination with Trypsin. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image KIMOSE Trypsin (1 mg) + Bromelains (50 mg) Tablet, sugar coated Oral บริษัท นิวไลฟ์ฟาร์ม่า จำกัด จำกัด 1998-01-27 2019-10-21 Thailand Phlogenzym - Filmtabletten Trypsin (1440 FIP units) + Bromelains (250 FIP units) + Rutoside trihydrate (100 mg) Tablet, film coated Oral Mucos Pharma Gmb H & Co.Kg 1998-10-28 Not applicable Austria Rutozym - Filmtabletten Trypsin (1440 FIP units) + Bromelains (450 FIP units) + Rutoside trihydrate (100 mg) Tablet, film coated Oral Mucos Pharma Gmb H & Co.Kg 2001-08-02 Not applicable Austria Traumazym - Filmtabletten Trypsin (1440 FIP units) + Bromelains (450 FIP units) + Rutoside trihydrate (100 mg) Tablet, film coated Oral Mucos Pharma Gmb H & Co.Kg 2001-08-02 Not applicable Austria Wobe - Mugos magensaftresistente Tabletten Trypsin (1740 FIP units) + Chymotrypsin (12000 FIP units) + Papain (270 FIP units) Tablet, delayed release Oral Mucos Pharma Gmb H & Co.Kg 1976-02-13 Not applicable Austria - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Granulex Trypsin (0.12 mg/1g) + Balsam of Peru (87 mg/1g) + Castor oil (788 mg/1g) Spray Topical Mylan Institutional 1967-03-01 2018-05-31 US Optase Trypsin (0.012 g/100g) + Balsam of Peru (8.69 g/100g) + Castor oil (78.77 g/100g) Gel Topical Onset Dermatologics, LLC 2006-04-01 2011-12-31 US Trypsin Complex Trypsin (0.0036 mg/1g) + Balsam of Peru (87.0 mg/1g) + Castor oil (788.0 mg/1g) Ointment Topical Breckenridge Pharmaceutical, Inc. 2009-10-21 2011-06-30 US Vasolex Trypsin (90 [USP'U]/1g) + Balsam of Peru (87 mg/1g) + Castor oil (788 mg/1g) Ointment Topical Stratus Pharmacuticals 2007-02-07 2015-04-09 US Xenaderm Trypsin (90 [USP'U]/1g) + Balsam of Peru (87.0 mg/1g) + Castor oil (788.0 mg/1g) Ointment Topical Healthpoint 2002-03-01 2015-03-02 US
Categories
- ATC Codes
- B06AA07 — Trypsin
- B06AA — Enzymes
- B06A — OTHER HEMATOLOGICAL AGENTS
- B06 — OTHER HEMATOLOGICAL AGENTS
- B — BLOOD AND BLOOD FORMING ORGANS
- D03BA — Proteolytic enzymes
- D03B — ENZYMES
- D03 — PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
- D — DERMATOLOGICALS
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- GV54A213NN
- CAS number
- 9002-07-7
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
- General References
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Treatment Sepsis / Septic Shock 1 4 Suspended Treatment Pancreatitis 1 4 Unknown Status Treatment Congenital Heart Disease (CHD) 1 2 Completed Treatment Wound 1 2 Terminated Treatment Pressure Ulcers / Spinal Cord Injuries 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Spray Topical Tablet, sugar coated Oral Gel Topical Tablet, film coated Oral Ointment Topical Tablet, delayed release Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 03, 2015 16:51 / Updated at April 30, 2021 13:08