Dihydroorotate dehydrogenase (DHODH) inhibitors

All categories
Name
Dihydroorotate dehydrogenase (DHODH) inhibitors
Accession Number
DBCAT005915
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
LeflunomideA pyrimidine synthesis inhibitor indicated to treat rheumatoid arthritis.
TeriflunomideA pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis.
Drugs & Drug Targets
DrugTargetType
LeflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
LeflunomideCytochrome P450 1A2enzyme
LeflunomideCytochrome P450 2C9enzyme
LeflunomideAryl hydrocarbon receptortarget
LeflunomideProtein-tyrosine kinase 2-betatarget
LeflunomideATP-binding cassette sub-family G member 2transporter
TeriflunomideATP-binding cassette sub-family G member 2transporter
TeriflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
TeriflunomideCytochrome P450 2C8enzyme
TeriflunomideSolute carrier organic anion transporter family member 1B1transporter
TeriflunomideCytochrome P450 1A2enzyme