Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.
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Castor CW, Walz DA, Ragsdale CG, Hossler PA, Smith EM, Bignall MC, Aaron BP, Mountjoy K
Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.
Biochem Biophys Res Commun. 1989 Sep 15;163(2):1071-8.
- PubMed ID
- 2783111 [ View in PubMed]
- Abstract
Evidence for three new isoforms of CTAP-III from human platelets is presented; two NH2-terminal cleavage products were identified, CTAP-III (des 1-13) and CTAP-III (des 1-15). CTAP-III (des 1-13) has a pI of 8.6 and is a relatively stable proteolytic cleavage product that retains the capacity to stimulate [14C]GAG synthesis in human synovial cell cultures. CTAP-III (des 1-15) appears to be an elastase or chymotrypsin cleavage product and identical to NAP-2, an entity thought to have neutrophil activating properties.