Ondansetron hydrochloride: a competitive serotonin 5-HT3 receptor blocker.
Article Details
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Mohan KC, Ravikumar K
Ondansetron hydrochloride: a competitive serotonin 5-HT3 receptor blocker.
Acta Crystallogr C. 1995 Dec 15;51 ( Pt 12):2627-9.
- PubMed ID
- 8588861 [ View in PubMed]
- Abstract
The methyl substituted imidazole ring in the title compound, 2-methyl-1-(9-methyl-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-3-yl) imidazol-3-ium chloride dihydrate, C18H20N3O+.Cl-.2H2O, is approximately perpendicular to the carbazole plane [dihedral angle 87.0(1) degrees]. The water molecules are involved in an elaborate network of hydrogen bonds that reinforce the stability of the dihydrate and the cohesion of the structure.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ondansetron 5-hydroxytryptamine receptor 3A Protein Humans YesAntagonistDetails