Structures of the bacterial ribosome at 3.5 A resolution.
Article Details
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Schuwirth BS, Borovinskaya MA, Hau CW, Zhang W, Vila-Sanjurjo A, Holton JM, Cate JH
Structures of the bacterial ribosome at 3.5 A resolution.
Science. 2005 Nov 4;310(5749):827-34.
- PubMed ID
- 16272117 [ View in PubMed]
- Abstract
We describe two structures of the intact bacterial ribosome from Escherichia coli determined to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed view of the interface between the small and large ribosomal subunits and the conformation of the peptidyl transferase center in the context of the intact ribosome. Differences between the two ribosomes reveal a high degree of flexibility between the head and the rest of the small subunit. Swiveling of the head of the small subunit observed in the present structures, coupled to the ratchet-like motion of the two subunits observed previously, suggests a mechanism for the final movements of messenger RNA (mRNA) and transfer RNAs (tRNAs) during translocation.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID 30S ribosomal protein S4 P0A7V8 Details 30S ribosomal protein S9 P0A7X3 Details 30S ribosomal protein S10 P0A7R5 Details 30S ribosomal protein S12 P0A7S3 Details 50S ribosomal protein L4 P60723 Details 30S ribosomal protein S14 P0AG59 Details 30S ribosomal protein S13 P0A7S9 Details 30S ribosomal protein S19 P0A7U3 Details 50S ribosomal protein L16 P0ADY7 Details 30S ribosomal protein S3 P0A7V3 Details 30S ribosomal protein S8 P0A7W7 Details 30S ribosomal protein S7 P02359 Details