Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.
Article Details
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Yamamoto M, Ikeda S, Kondo H, Inoue S
Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.
Bioorg Med Chem Lett. 2002 Feb 11;12(3):375-8.
- PubMed ID
- 11814800 [ View in PubMed]
- Abstract
The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID Interstitial collagenase IC 50 (nM) 3 N/A N/A Details