Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors.
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Lam B, Zhang Z, Stafford JA, Skene RJ, Shi L, Gwaltney SL 2nd
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett. 2012 Nov 1;22(21):6628-31. doi: 10.1016/j.bmcl.2012.08.110. Epub 2012 Sep 7.
- PubMed ID
- 23025999 [ View in PubMed]
- Abstract
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 1-biphenyl-2-ylmethanamine Dipeptidyl peptidase 4 IC 50 (nM) 30000 N/A N/A Details