Self-association of okadaic acid upon complexation with potassium ion.
Article Details
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Daranas AH, Fernandez JJ, Morales EQ, Norte M, Gavin JA
Self-association of okadaic acid upon complexation with potassium ion.
J Med Chem. 2004 Jan 1;47(1):10-3.
- PubMed ID
- 14695814 [ View in PubMed]
- Abstract
Okadaic acid (OA) is a toxin responsible for diarrhetic shellfish poisoning and is an extremely useful tool for studying processes that are regulated by phosphorylation, although the exact mechanism of action is still undetermined. We report on a study that proved the existence of OA in an unusual dimeric form when complexed with potassium ion. The proposed structure of this dimer is based on spectroscopic and conformational studies.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 9,10-Deepithio-9,10-Didehydroacanthifolicin Serine/threonine-protein phosphatase PP1-gamma catalytic subunit IC 50 (nM) 20 N/A N/A Details