Wake promoting agents: search for next generation modafinil, lessons learned: part III.
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Dunn D, Hostetler G, Iqbal M, Marcy VR, Lin YG, Jones B, Aimone LD, Gruner J, Ator MA, Bacon ER, Chatterjee S
Wake promoting agents: search for next generation modafinil, lessons learned: part III.
Bioorg Med Chem Lett. 2012 Jun 1;22(11):3751-3. doi: 10.1016/j.bmcl.2012.04.031. Epub 2012 Apr 13.
- PubMed ID
- 22546675 [ View in PubMed]
- Abstract
In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Modafinil Cytochrome P450 2C19 IC 50 (nM) 11000 N/A N/A Details