Neuroleptic binding to human brain receptors: relation to clinical effects.
Article Details
- CitationCopy to clipboard
Richelson E
Neuroleptic binding to human brain receptors: relation to clinical effects.
Ann N Y Acad Sci. 1988;537:435-42.
- PubMed ID
- 2904784 [ View in PubMed]
- Abstract
Table 2 summarizes the potential clinical consequences of neurotransmitter receptor blockade by neuroleptics. These pharmacological effects of neuroleptics at receptors in brain and elsewhere in the body are likely responsible for therapeutic and certain adverse effects as well as some drug-drug interactions. Data presented here should allow the physician a rational basis for selecting neuroleptics to minimize these unwanted effects in patients.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Chlorpromazine 5-hydroxytryptamine receptor 2C Ki (nM) 1.4 N/A N/A Details Chlorpromazine Histamine H1 receptor Ki (nM) 9.09 N/A N/A Details Clozapine 5-hydroxytryptamine receptor 2C Ki (nM) 1.58 N/A N/A Details Clozapine Alpha-2A adrenergic receptor Ki (nM) 161.29 N/A N/A Details Clozapine Histamine H1 receptor Ki (nM) 2.77 N/A N/A Details Clozapine Muscarinic acetylcholine receptor M2 Ki (nM) 12.04 N/A N/A Details Diphenhydramine Histamine H1 receptor Ki (nM) 14.08 N/A N/A Details Fluphenazine 5-hydroxytryptamine receptor 2C Ki (nM) 188.67 N/A N/A Details Loxapine 5-hydroxytryptamine receptor 2C Ki (nM) 1.69 N/A N/A Details Loxapine Alpha-2A adrenergic receptor Ki (nM) 2380.95 N/A N/A Details Loxapine Histamine H1 receptor Ki (nM) 5 N/A N/A Details Loxapine Muscarinic acetylcholine receptor M2 Ki (nM) 454.54 N/A N/A Details Methysergide 5-hydroxytryptamine receptor 2C Ki (nM) 6.66 N/A N/A Details Promazine 5-hydroxytryptamine receptor 2C Ki (nM) 15.87 N/A N/A Details Promazine Histamine H1 receptor Ki (nM) 2 N/A N/A Details