cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family.
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Wu X, Prasad PD, Leibach FH, Ganapathy V
cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family.
Biochem Biophys Res Commun. 1998 May 29;246(3):589-95.
- PubMed ID
- 9618255 [ View in PubMed]
- Abstract
We have cloned OCTN2, a new member of the organic cation transporter family, from a human placental trophoblast cell line. The hOCTN2 cDNA codes for a protein of 557 amino acids with twelve putative transmembrane domains. The octn2 gene, located on human chromosome 5q31, consists of ten exons. The OCTN2-specific transcript, 3.5 kb in size, is expressed widely in human tissues and in cell lines of human origin. At the level of amino acid sequence, OCTN2 is more closely related to OCTN1 than to OCT1, OCT2 and OCT3. When expressed heterologously in HeLa cells, OCTN2 mediates the transport of tetraethylammonium, a prototypical organic cation, in a pH-dependent manner. Several organic cations, including the neurotoxins 1-methyl-4-phenylpyridinium, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and methamphetamine, compete for the OCTN2-mediated transport process.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Amphetamine Solute carrier family 22 member 5 Protein Humans UnknownSubstrateDetails Choline Solute carrier family 22 member 5 Protein Humans UnknownInhibitorDetails Choline salicylate Solute carrier family 22 member 5 Protein Humans UnknownInhibitorDetails Cimetidine Solute carrier family 22 member 5 Protein Humans UnknownInhibitorDetails Guanidine Solute carrier family 22 member 5 Protein Humans UnknownInhibitorDetails Metamfetamine Solute carrier family 22 member 5 Protein Humans UnknownInhibitorDetails Nicotine Solute carrier family 22 member 5 Protein Humans UnknownInhibitorDetails Procainamide Solute carrier family 22 member 5 Protein Humans UnknownInhibitorDetails - Polypeptides
Name UniProt ID Solute carrier family 22 member 5 O76082 Details