A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.
Article Details
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Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhajcer OL, Chenard MP, Rio MC, Chambon P
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.
Nature. 1990 Dec 20-27;348(6303):699-704.
- PubMed ID
- 1701851 [ View in PubMed]
- Abstract
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.